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- Lindmark, F, et al.
(författare)
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Interleukin-1 receptor antagonist haplotype associated with prostate cancer risk
- 2005
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Ingår i: British Journal of Cancer. - Umea Univ, Dept Radiat Sci Oncol, S-90187 Umea, Sweden. Wake Forest Univ, Bowman Gray Sch Med, Ctr Human Genom, Winston Salem, NC USA. Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden. Johns Hopkins Med Inst, Dept Urol, Baltimore, MD 21205 USA. Orebro Univ Hosp, Dept Urol & Clin Med, Orebro, Sweden. Univ Hosp, Reg Oncol Ctr, Uppsala, Sweden. : NATURE PUBLISHING GROUP. - 0007-0920 .- 1532-1827. ; 93:4, s. 493-497
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Tidskriftsartikel (refereegranskat)abstract
- IL1-RN is an important anti-inflammatory cytokine that modulate the inflammation response by binding to IL1 receptors, and as a consequence inhibits the action of proinflammatory cytokines IL1 alpha and IL1 beta. In this study, we hypothesise that sequence variants in the IL1-RN gene are associated with prostate cancer risk. The study population, a population-based case - control study in Sweden, consisted of 1383 prostate cancer case patients and 779 control subjects. We first selected 18 sequence variants covering the IL1-RN gene and genotyped these single-nucleotide polymorphisms ( SNPs) in 96 control subjects. Gene-specific haplotypes of IL1-RN were constructed and four haplotype-tagging single-nucleotide polymorphisms (htSNPs) were identified (rs878972, rs315934, rs3087263 and rs315951) that could uniquely describe 495% of the haplotypes. All study subjects were genotyped for the four htSNPs. No significant difference in genotype frequencies between cases and controls were observed for any of the four SNPs based on a multiplicative genetic model. Overall there was no significant difference in haplotype frequencies between cases and controls; however, the prevalence of the most common haplotype (ATGC) was significantly higher among cases (38.7%) compared to controls (33.5%) ( haplotype-specific P = 0.009). Evaluation of the prostate cancer risk associated with carrying the 'ATGC' haplotype revealed that homozygous carriers were at significantly increased risk ( odds ratio (OR) = 1.6, 95% confidence interval (CI) = 1.2 - 2.2), compared to noncarriers, while no significant association was found among subjects heterozygous for the haplotype ( OR = 1.0, 95% CI = 0.8 - 1.2). Restricting analyses to advanced prostate cancer strengthened the association between the 'ATGC' haplotype and disease risk (OR for homozygous carriers vs noncarriers 1.8, 95% CI = 1.3 - 2.5). In conclusion, the results from this study support the hypothesis that inflammation has a role of in the development of prostate cancer, but further studies are needed to identify the causal variants in this region and to elucidate the biological mechanism for this association.
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| 5. |
- Freni, A., et al.
(författare)
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The European school of antennas within the ACE network
- 2005
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Ingår i: 35th European Microwave Conference 2005. - 2960055128 - 9782960055122 ; , s. 793-796
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Konferensbidrag (refereegranskat)abstract
- The Antenna Center of Excellence (ACE) Is a Network of Excellence funded by the EC 6th Framework Program. This paper describes the activities on Training and Education within the network and In particular the organization of a European School of Antennas with short courses on different antenna related topics taught be recognized experts In the respective fields.
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| 6. |
- Godi, G., et al.
(författare)
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Applications of the DG-FDTD method
- 2007
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Ingår i: 2nd European Conference on Antennas and Propagation, EuCAP 2007. - : Institution of Engineering and Technology. - 9780863418426
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Konferensbidrag (refereegranskat)abstract
- In this paper, we propose to use the dual-grid finite-difference time-domain (DG-FDTD) approach to analyze the characteristics of several antenna configurations. This method reduces the overall computational time and besides, it prevents from instabilities. It has been applied to the analysis of far-field and impedance characteristics of an integrated lens antenna and of a MIMO array. A dosimetry problem for phone / head interaction is also presented in the paper.
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