| 1. |
- Lindskog, Anders, et al.
(author)
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A Russian record of a Middle Ordovician meteorite shower: Extraterrestrial chromite at Lynna River, St. Petersburg region
- 2012
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In: Meteoritics and Planetary Science. - : Wiley. - 1086-9379. ; 47:8, s. 1274-1290
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Journal article (peer-reviewed)abstract
- Numerous fossil meteorites and high concentrations of sediment-dispersed extraterrestrial chromite (EC) grains with ordinary chondritic composition have previously been documented from 467 +/- 1.6 Ma Middle Ordovician (Darriwilian) strata. These finds probably reflect a temporarily enhanced influx of L-chondritic matter, following the disruption of the L-chondrite parent body in the asteroid belt 470 +/- 6 Ma. In this study, a Volkhovian-Kundan limestone/marl succession at Lynna River, northwestern Russia, has been searched for EC grains (>63 mu m). Eight samples, forming two separate sample sets, were collected. Five samples from strata around the Asaphus expansusA. raniceps trilobite Zone boundary, in the lower-middle Kundan, yielded a total of 496 EC grains in 65.5 kg of rock (average 7.6 EC grains kg-1, but up to 10.2 grains kg-1). These are extremely high concentrations, three orders of magnitude higher than background levels in similar condensed sediment from other periods. EC grains are typically about 50 times more abundant than terrestrial chrome spinel in the samples and about as common as terrestrial ilmenite. Three stratigraphically lower lying samples, close to the A. lepidurusA. expansus trilobite Zone boundary, at the Volkhov-Kunda boundary, yielded only two EC grains in 38.2 kg of rock (0.05 grains kg-1). The lack of commonly occurring EC grains in the lower interval probably reflects that these strata formed before the disruption of the L-chondrite parent body. The great similarity in EC chemical composition between this and other comparable studies indicates that all or most EC grains in these Russian mid-Ordovician strata share a common sourcethe L-chondrite parent body.
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| 2. |
- Lindskog, Sven, et al.
(author)
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Validation of an Algorithm for Chronic Periodontitis Risk Assessment and Prognostication : Analysis of an Inflammatory Reactivity Test and Selected Risk Predictors
- 2010
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In: Journal of Periodontology. - : American Academy of Periodontology. - 0022-3492 .- 1943-3670. ; 81:6, s. 837-847
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Journal article (peer-reviewed)abstract
- Background: Patients with severe forms of chronic periodontitis present with varying degrees of decreased inflammatory reactivity. A previously reported algorithm for chronic periodontitis risk assessment and prognostication is based on the analysis of some 20 risk predictors. One of these predictors is a skin provocation test that assesses the individual patient's reactivity to a lipid A challenge. The aim of this report was to analyze results from validation data for the algorithm with respect to the contribution of results of the skin provocation test as a risk predictor for the progression of chronic periodontitis and to compare these results with the contribution from other predictors, namely smoking, angular bony destruction, furcation involvement, abutment teeth, and endodontic pathology. Methods: Data from a previously reported clinical validation sample were used for the analysis, including the calculation of quality measures and explanatory values using different types of regression analysis and non-parametric testing. Results: Smoking, endodontic pathology, abutment teeth, angular bony destruction, and furcation involvement presented with individual explanatory values for periodontitis progression between 4% and 13% and highly significant parameter estimates. Explanatory values for the results of the skin provocation test ranged between 2.6% and 5.1% depending on the disease severity group, with a positive predictive value of 82% for the identification of high-risk patients. Conclusion: The skin provocation test provided a clinically significant contribution to the quality of analysis with the periodontitis risk and prognostication algorithm, in particular in the selection of high-risk patients for in-depth individual tooth analysis.
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| 3. |
- Lindskog, Sven, et al.
(author)
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Validation of an Algorithm for Chronic Periodontitis Risk Assessment and Prognostication: Risk Predictors, Explanatory Values, Measures of Quality, and Clinical Use
- 2010
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In: JOURNAL OF PERIODONTOLOGY. - : American Academy of Periodontology. - 0022-3492 .- 1943-3670. ; 81:4, s. 584-593
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Journal article (peer-reviewed)abstract
- Background: The American Academy of Periodontology has recently stated that, "[risk assessment will become] increasingly important in periodontal treatment planning and should be part of every comprehensive dental and periodontal evaluation." (J Periodontol 2006;77:1608). Unaided risk assessment and prognostication show significant variability because chronic periodontitis is a multifactorial disease. This report summarizes the clinical validation of an algorithm for chronic periodontitis risk assessment and prognostication. The algorithm is a Web-based analytic tool that integrates some 20 risk predictors and calculates scores indicating levels of risk for chronic periodontitis for the dentition (Level I) and, if an elevated risk is found, prognosticates disease progression tooth by tooth (Level II). Methods: An independent clinical validation sample was generated in an open, prospective clinical trial and analyzed in a predetermined validation plan. Results: The analyses identified two threshold scores above which significant progression of periodontitis was found. Based on these scores, sufficiently high explanatory values with significant and increasing parameter estimates for increasing risk were established in Level I, justifying detailed analysis tooth by tooth in Level II. Subsequent prognostication of chronic periodontitis in Level II was found to be accompanied by clinically relevant measures of quality in relation to rates of disease progression. Three score intervals representing increasing levels of periodontitis progression were identified corresponding to increasing levels of significant annual marginal bone loss. Conclusions: The predictors included in the algorithm reflect a relevant selection for periodontitis risk assessment. Risk assessment and prognostication with the algorithm provides the clinician with a validated, reliable, consistent, and objective tool supporting treatment planning.
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| 4. |
- Edlund, Karolina, et al.
(author)
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CD99 is a novel prognostic stromal marker in non-small cell lung cancer
- 2012
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In: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 131:10, s. 2264-2273
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Journal article (peer-reviewed)abstract
- The complex interaction between cancer cells and the microenvironment plays an essential role in all stages of tumourigenesis. Despite the significance of this interplay, alterations in protein composition underlying tumourstroma interactions are largely unknown. The aim of this study was to identify stromal proteins with clinical relevance in non-small cell lung cancer (NSCLC). A list encompassing 203 stromal candidate genes was compiled based on gene expression array data and available literature. The protein expression of these genes in human NSCLC was screened using the Human Protein Atlas. Twelve proteins were selected that showed a differential stromal staining pattern (BGN, CD99, DCN, EMILIN1, FBN1, PDGFRB, PDLIM5, POSTN, SPARC, TAGLN, TNC and VCAN). The corresponding antibodies were applied on tissue microarrays, including 190 NSCLC samples, and stromal staining was correlated with clinical parameters. Higher stromal expression of CD99 was associated with better prognosis in the univariate (p = 0.037) and multivariate (p = 0.039) analysis. The association was independent from the proportion of tumour stroma, the fraction of inflammatory cells and clinical and pathological parameters like stage, performance status and tumour histology. The prognostic impact of stromal CD99 protein expression was confirmed in an independent cohort of 240 NSCLC patients (p = 0.008). Furthermore, double-staining confocal fluorescence microscopy showed that CD99 was expressed in stromal lymphocytes as well as in cancer-associated fibroblasts. Based on a comprehensive screening strategy the membrane protein CD99 was identified as a novel stromal factor with clinical relevance. The results support the concept that stromal properties have an important impact on tumour progression.
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| 5. |
- Eriksson, Mats, et al.
(author)
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Biotic dynamics and carbonate microfacies of the conspicuous Darriwilian (Middle Ordovician) 'Taljsten' interval, south-central Sweden
- 2012
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In: Palaeogeography, Palaeoclimatology, Palaeoecology. - : Elsevier BV. - 1872-616X .- 0031-0182. ; 367, s. 89-103
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Journal article (peer-reviewed)abstract
- Enclosed in the Darriwilian (Middle Ordovician) part of the reddish 'orthoceratite limestone' of Baltoscandia is a conspicuous c. 1.5 m thick unit colloquially known as the 'Taljsten' interval. It has a wide geographical distribution in the Baltoscandian paleocontinent but is particularly well exposed in south-central Sweden. The unit is characterized by its deviant gray color and beds with a mass occurrence of cystoid echinoderms. Moreover, the recent discovery of an anomalous abundance of extraterrestrial chromite grains and micrometeorites in the 'Taljsten' and immediately adjacent strata bear witness of a time of deposition correlating to an increased influx of extraterrestrial matter to Earth. In this study we analyze the faunal dynamics, based primarily on microfossils and carbonate microfacies, across this intriguing interval. Generally known as a macrolithologically monotonous succession, the 'Taljsten' proved more heterogeneous than previously believed in terms of fossil content and preservation, as well as mineral content and composition. The general texture is wackestone/packstone, but local heterogeneities are frequent. A microfaunal reorganization occurred with a transition from a trilobite- and brachiopod-dominated community to one dominated by echinoderms, which is mirrored also macroscopically by the cystoids. The latter pelmatozoans seem to have flourished and might even have aided in the formation of the numerous hardgrounds. The increase in echinoderms is linked to a Volkhovian increase in echinoderms in eastern Baltica. In the immediate post-'Taljsten' strata there is no distinct change back to the pre-'Taljsten' biota. Conodont and ostracod faunal diversity data reveal peak values in the 'Taljsten' compared to the enclosing strata, suggesting that the paleoenvironment was more suitable for higher diversity faunas of these metazoan groups. All data collectively support a regression in the beginning of the 'Taljsten', likely followed by transgression in its upper part. (C) 2012 Elsevier B.V. All rights reserved.
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| 6. |
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| 7. |
- Jain, Sanjay, et al.
(author)
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Multi-Resolution Modeling for Supply Chain Sustainability Analysis
- 2013
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In: Proceedings of the 2013 Winter Simulation Conference. - 9781479920778 ; , s. 1996-2007
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Conference paper (peer-reviewed)abstract
- Consumers are increasingly becoming conscious of the need to reduce environmental impact. This hasmotivated the industry to make efforts to improve the sustainability of their products and supply chains.Such efforts require the ability to analyze the sustainability of supply chains and potential improvements.A systematic approach is needed to evaluate the alternatives that may range from those at the supplychain configuration level to those for improving equipment at a production facility. This paper presents amulti-resolution modeling approach that allows analyzing parts of the supply chain at appropriate level ofdetail. The capability allows studying the supply chain at high level initially and iteratively drilling downto detailed levels in the identified areas of opportunity and evaluating associated improvement alternatives.Multi-resolution modeling directly relates the impact of improvement in one part of the supplychain to overall supply chain performance thus reducing analyst effort and time.
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| 8. |
- Johansson, Björn, 1975, et al.
(author)
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Evaluation and Calculation of Dynamics in Environmental Impact Assessment
- 2013
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In: IFIP Advances in Information and Communication Technology. - Berlin, Heidelberg : Springer Berlin Heidelberg. - 1868-4238 .- 1868-422X. - 9783642403514 ; 397:1, s. 135-141
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Conference paper (peer-reviewed)abstract
- In ten years customers will select products not only based on price and quality but also with strong regard to the product value environmental footprint, including for example the energy consumed. Customers expect transparency in the product realization process, where most products are labeled with their environmental footprint. Vigorous companies see this new product value as an opportunity to be more competitive. In order to effectively label the envi-ronmental impact of a product, it is pertinent for companies to request the envi-ronmental footprint of each component from their suppliers. Hence, companies along the product lifecycle require a tool, not only to facilitate the computing of the environmental footprint, but also help reduce/balance the environmental impact during the lifecycle of the product. This paper proposes to develop a procedure that companies will use to evaluate, improve and externally advertise their product’s environmental footprint to customers.
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| 9. |
- Josefsson, Oskar, 1985, et al.
(author)
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Assessment of a Multilevel Converter for a PHEV charge and traction application
- 2010
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In: XIX International Conference on Electrical Machines (ICEM), 2010, Rome, 6-8 Sept. 2010. - 9781424441747
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Conference paper (peer-reviewed)abstract
- With the Plug in Hybrid Electric Vehicle (PHEV) the introduction of a charger has to be done. A standalone onboard charger will increase both weight and cost of the vehicle. A better option is the integration of the charging function into the already existing propulsion converter. The aim of this paper is to assess the multilevel converter as an integrated vehicle charge and propulsion converter. A comparison between conventional converter technology and multilevel converter technology is made both on component level and system level. The investigation, based on calculations, simulations and measurements, points to some features that can; increase the efficiency of the total system; increase the life time of the energy storage; and increase the utilization of the energy storage. However, the investigation also points to features that can increase the cost and complexity of the system and reduce efficiency in certain operation points.
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| 10. |
- Juslin, Peter, et al.
(author)
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Reducing cognitive biases in probabilistic reasoning by the use of logarithm formats
- 2011
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In: Cognition. - : Elsevier BV. - 0010-0277 .- 1873-7838. ; 120:2, s. 248-267
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Journal article (peer-reviewed)abstract
- Research on probability judgment has traditionally emphasized that people are susceptible to biases because they rely on "variable substitution": the assessment of normative variables is replaced by assessment of heuristic, subjective variables. A recent proposal is that many of these biases may rather derive from constraints on cognitive integration, where the capacity-limited and sequential nature of controlled judgment promotes linear additive integration, in contrast to many integration rules of probability theory (juslin, Nilsson, & Winman, 2009). A key implication by this theory is that it should be possible to improve peoples' probabilistic reasoning by changing probability problems into logarithm formats that require additive rather than multiplicative integration. Three experiments demonstrate that recasting tasks in a way that allows people to arrive at the answers by additive integration decreases cognitive biases, and while people can rapidly learn to produce the correct answers in an additive formats, they have great difficulty doing so with a multiplicative format.
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