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- Lingman, Markus, 1975
(författare)
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Acute coronary syndromes. The prognostic importance of hypertension, diabetes and vectorcardiographic markers
- 2013
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Research questions: 1 Is hypertension and diabetes associated with the future risk of death, and recurrent manifestations of cardiovascular disease in acute coronary syndromes (ACS)? 2 How does myocardial ischemia affect depolarization and repolarization of the heart during the early phase of an acute myocardial infarction? 3 What is the prognostic value of accepted vectorcardiographic markers in relation to future risk of sudden cardiac death after ACS? Methodology: Papers I, III and IV studied patients with ACS prospectively and consecutively included at the coronary care unit of Sahlgrenska University Hospital. Paper I deals with 2,329 patients who were followed for a median of 8 years. Paper III included 57 patients who were diagnosed with an anterior ST-elevation myocardial infarction with vectorcardiographic (VCG) registration starting within 4 hours from onset of chest pain and showing dynamic ST-vector magnitude. Paper IV investigated 643 patients who were subject to cardiac ultrasound and VCG registration during hospital stay and followed for 30 months. Clinical data and data on complications and pharmacological treatment were collected from hospital records and interviews. The Swedish National Population Register, the Swedish Cause of Death Register and the Swedish Hospital Discharge Register completed end-point data in paper I, II and IV. Paper II included 44,268 patients in the Swedish Coronary Angiography and Angioplasty Registry (SCAAR) during 2006 through 2008 with the whole spectrum of coronary artery disease. They were followed for an average 1.9 years. The SCAAR was also merged with the Swedish prescribed drug Register. All prognostic results were adjusted for background data. Results: Paper I reports that diabetes was a predictor of death (HR 1.79; 95% CI 1.52-2.10) with an additive effect of hypertension (HR 2.10, 95% CI 1.71–2.57). In paper II hypertension increased the risk of myocardial infarction, stroke and congestive heart failure with a strong additive adverse effect of diabetes while hypertension alone was not a marker of the risk of death. The 10% increase in the risk of myocardial infarction during follow-up by hypertension was quadrupled by diabetes. In paper III the overall ventricular repolarization dispersion (Tarea) almost tripled (118 vs. 41μVs; p<.0001) and the heterogeneity of the action potential morphology (ventricular gradient) was 2.6 times higher (127 vs 49 μVs; p<.0001) at maximum than at minimum ischemia as judged from the degree of ST-elevation. In paper IV a wide angle between the main direction of depolarization and repolarization (QRS-T area angle) increased the risk of sudden cardiac death by 63% after adjusting for the left ventricular ejection fraction. Conclusions: Diabetes is strongly associated with the risk of death after an ACS with a small additive effect of hypertension. Hypertension alone is associated with myocardial infarction, stroke and congestive heart failure during follow-up but diabetes is a more important risk factor. Myocardial ischemia initially and transiently increases the heterogeneity of repolarization which might explain why the risk of ventricular fibrillation is also transient and lacks prognostic value. A wide QRS-T area angle measured early after an acute coronary syndrome predicts sudden cardiac death regardless of left ventricular dysfunction.
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| 2. |
- Lingman, Markus, 1975, et al.
(författare)
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The Impact of Hypertension and Diabetes on Outcome in Patients Undergoing Percutaneous Coronary Intervention
- 2011
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Ingår i: American Journal of Medicine. - : Elsevier BV. - 0002-9343 .- 1555-7162. ; 124:3, s. 265-275
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: Information relating the outcome of percutaneous coronary intervention to diabetes mellitus or hypertension is limited. The study objective was to describe the outcome in patients undergoing percutaneous coronary intervention in relation to diabetes and hypertension. METHODS: Data were extracted from 5 national registers: the Swedish Coronary Angiography and Angioplasty Register (all percutaneous coronary interventions), the Prescribed Drug Registry (all prescribed pharmaceuticals purchased in Swedish pharmacies), the Swedish Hospital Discharge Register (data on myocardial infarction, revascularization, stroke, and congestive heart failure from in-hospital and specialist health care), and the National Population Register and Cause of Death Register (data on death). We included all "first percutaneous coronary interventions" between January 1, 2006, and December 31, 2008 (n = 44,268; followed an average of 1.9 [+/- 0.9] years). RESULTS: Mortality was 6.4% and highest in patients with diabetes plus hypertension. Hypertension per se did not increase mortality or the risk for repeat intervention, but carried a 10% increased risk for subsequent myocardial infarction, increasing to a 4-fold increase when combined with diabetes. Stroke occurred in 2%; the importance of hypertension was evident in nondiabetic patients, but even stronger in diabetic patients. Congestive heart failure caused hospital admission in 8%, with a negative influence from hypertension with and without diabetes. CONCLUSION: After percutaneous coronary intervention and with modern pharmacotherapy, diabetes had a negative effect on the outcome, especially when combined with hypertension. Hypertension per se was not associated with increased mortality but with an increased risk for myocardial infarction, stroke, and congestive heart failure, probably related to widespread coronary artery disease. Improved diabetes care might improve the prognosis.
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| 3. |
- Lingman, Markus, 1975, et al.
(författare)
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Transient repolarization alterations dominate the initial phase of an acute anterior infarction-a vectorcardiography study
- 2014
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Ingår i: Journal of Electrocardiology. - : Churchill Livingstone. - 0022-0736 .- 1532-8430. ; 47:4, s. 478-485
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To study effects of ischemia-reperfusion on ventricular electrophysiology in humans by three-dimensional electrocardiography. METHODS: Fifty-seven patients with first-time acute anterior ST elevation myocardial infarction were monitored from admission and >24h after symptom onset with continuous vectorcardiography (VCG; modified Frank orthogonal leads). Global ventricular depolarization and repolarization (VR) measures were compared at maximum vs. minimum ST vector magnitude (STVM) (median 208; 111-303 vs. 362; 165-1359min after symptom onset). RESULTS: At maximum vs. minimum STVM the Tarea (overall VR dispersion) almost tripled (118 vs. 41μVs; p<0.0001), the T-loop bulginess was 90% greater (Tavplan 0.91 vs 0.48μV; p<0.0001), and Tpeak-end/QT was 39% larger (0.32 vs 0.23; p<0.0001). QRSarea (overall dispersion of depolarization) was 12% larger at maximum STVM, while QRS duration was 10% longer at minimum STVM. CONCLUSIONS: Ischemia-reperfusion was accompanied by profound and transient alterations of VR dispersion, while changes in depolarization were modest and delayed.
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