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| 2. |
- Berry, Teeara, et al.
(författare)
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The ALK(F1174L) mutation potentiates the oncogenic activity of MYCN in neuroblastoma
- 2012
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Ingår i: Cancer Cell. - : Elsevier BV. - 1535-6108 .- 1878-3686. ; 22:1, s. 117-130
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Tidskriftsartikel (refereegranskat)abstract
- The ALK(F1174L) mutation is associated with intrinsic and acquired resistance to crizotinib and cosegregates with MYCN in neuroblastoma. In this study, we generated a mouse model overexpressing ALK(F1174L) in the neural crest. Compared to ALKF1174L and MYCN alone, co-expression of these two oncogenes led to the development of neuroblastomas with earlier onset, higher penetrance, and enhanced lethality. ALK(F1174L)/MYCN tumors exhibited increased MYCN dosage due to ALK(F1174L)-induced activation of the PI3K/AKT/mTOR and MAPK pathways, coupled with suppression of MYCN pro-apoptotic effects. Combined treatment with the ATP-competitive mTOR inhibitor Torin2 overcame the resistance of ALK(F1174L)/MYCN tumors to crizotinib. Our findings demonstrate a pathogenic role for ALK(F1174L) in neuroblastomas overexpressing MYCN and suggest a strategy for improving targeted therapy for ALK-positive neuroblastoma.
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| 3. |
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| 4. |
- Ji, Guomin, et al.
(författare)
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Enhanced rectifying performance by asymmetrical gate voltage for BDC20 molecular devices
- 2014
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Ingår i: RSC Advances. - : Royal Society of Chemistry. - 2046-2069. ; 4:32, s. 16537-16544
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Tidskriftsartikel (refereegranskat)abstract
- By applying the asymmetrical gate voltage on the 1,4-bis (fullero[c]pyrrolidin-1-yl) benzene BDC20 molecule, we investigate theoretically its electronic transport properties using the density functional theory and nonequilibrium Greens function formalism for a unimolecule device with metal electrodes. Interestingly, the rectifying characteristic with very high rectification ratio, 91.7 and 24.0, can be obtained when the gate voltage is asymmetrically applied on the BDC20 molecular device. The rectification direction can be tuned by the different gate voltage applying regions. The rectification behavior is understood in terms of the evolution of the transmission spectrum and projected density of states spectrum with applied bias combined with molecular projected self-consistent Hamiltonian states analyses. Our finding implies that to realize and greatly promote rectifying performance of the BDC20 molecule the variable gate voltage applying position might be a key
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| 5. |
- Ji, Guomin, et al.
(författare)
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Rectifying behaviors of an Au/(C-20)(2)/Au molecular device induced by the different positions of gate voltage
- 2012
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Ingår i: RSC ADVANCES. - : RSC Publishing. - 2046-2069. ; 2:30, s. 11349-11353
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Tidskriftsartikel (refereegranskat)abstract
- The electronic transport properties of a gated Au/(C-20)(2)/Au molecular device are studied using nonequilibrium Greens function in combination with density functional theory. The results show that different applied positions of the external transverse gate voltage can effectively tune the current-voltage (I-V) characteristic of molecular devices. Rectifying behaviors of the device can be realized when the gate voltage is applied asymmetrically on the left C-20 molecule, and the rectification directions can also be modulated by the positive or negative value of the gate voltage. These results provide an important theoretical support to experiments and the design of a molecular rectifier.
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| 6. |
- Liu, Meisheng, et al.
(författare)
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Productivity measurement of industrial sector in China regarding air pollution
- 2022
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Ingår i: Expert systems (Print). - : Wiley. - 0266-4720 .- 1468-0394. ; 39:2
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Tidskriftsartikel (refereegranskat)abstract
- As an important sector of national economy, the industrial sector accounts for 33.4% of gross domestic product while consuming 70% of energy and causing serious air pollution in China. It is meaningful to measure the productivity of industrial sector in China with air pollution consideration. The range-adjusted measure of the nonradial data envelopment analysis, as with natural disposability and managerial disposability, is adopted in order to measure the productivity of provincial industrial sector in China during 2011–2014. The results explain that the unified efficiency under managerial disposability is lower than the unified efficiency under natural disposability and the unified efficiency under natural and managerial disposability, which means that management improvement and technology innovation should be obtained more attention from the government. As modernization of economic restructuring, there is not a trend of unified efficiency under natural disposability. Eastern China has highest unified efficiency under managerial disposability, whereas unified efficiency under natural and managerial disposability are improving in eastern China and western China in period of 2013–2014. The results also describe that more than 20 provinces and nearly half of provinces are suitable for the industrial pollution control investment and research and development investment, respectively. On the basis of the results of the truncated regression model, we can identify the influencing factors of unified efficiency. According to above results, suggestions are proposed in order to improve the productivity.
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| 7. |
- Ren, Rui, et al.
(författare)
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Forecasting Stock Market Movement Direction Using Sentiment Analysis and Support Vector Machine
- 2019
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Ingår i: IEEE Systems Journal. - 1932-8184 .- 1937-9234. ; 13:1, s. 760-770
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Tidskriftsartikel (refereegranskat)abstract
- Investor sentiment plays an important role on the stock market. User-generated textual content on the Internet provides a precious source to reflect investor psychology and predicts stock prices as a complement to stock market data. This paper integrates sentiment analysis into a machine learning method based on support vector machine. Furthermore, we take the day-of-week effect into consideration and construct more reliable and realistic sentiment indexes. Empirical results illustrate that the accuracy of forecasting the movement direction of the SSE 50 Index can be as high as 89.93% with a rise of 18.6% after introducing sentiment variables. And, meanwhile, our model helps investors make wiser decisions. These findings also imply that sentiment probably contains precious information about the asset fundamental values and can be regarded as one of the leading indicators of the stock market.
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| 8. |
- Sun, Zhen, et al.
(författare)
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Scattering process between polaron and exciton in conjugated polymers
- 2011
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Ingår i: JOURNAL OF CHEMICAL PHYSICS. - : American Institute of Physics. - 0021-9606 .- 1089-7690. ; 134:4, s. 044906-
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Tidskriftsartikel (refereegranskat)abstract
- Scattering process between a negative polaron and an exciton in a polymer chain is investigated by using the Su-Schrieffer-Heeger model modified to include electron-electron interactions, the Brazovskii-Kirova symmetry breaking term, and an external electric field. It is found that the scattering process is spin dependent. If the polaron and the exciton have parallel spins, the polaron can easily pass through the exciton as if it "do not see" the exciton. If the polaron and the exciton have antiparallel spins, there exist strong repulsion between them. The polaron may be bounced back, be dissociated or pass through the exciton depending on the strength of the external electric field. In any of these cases, the polaron cannot break the exciton.
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| 9. |
- Tao, Liangyan, et al.
(författare)
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Optimal due date quoting for a risk-averse decision-maker under CVaR
- 2018
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Ingår i: International Journal of Production Research. - : Informa UK Limited. - 0020-7543 .- 1366-588X. ; 56:5, s. 1934-1959
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Tidskriftsartikel (refereegranskat)abstract
- This study investigates a due date quoting problem for a project with stochastic duration, taking the decision-maker's risk attitude into consideration. The project profit is defined as the difference between the price and the cost that is comprised of production cost and earliness-tardiness penalties. In this situation, the due date determination has to be modelled as a stochastic optimisation due to stochastic duration. Conditional value at risk is thus employed as a performance measure to describe the decision-maker's risk attitude. In fixed price contract, when the unit production cost is not smaller than the unit penalty on earliness, the optimal due date increases with the increase of the degree of a decision-maker's risk aversion, the unit penalty on delay, and the decrease of the unit penalty on earliness. Besides, when the price is proportional to the due date and the slope is no bigger than the unit penalty on tardiness, the optimal due date is smaller than the result in fixed price. This is because high price for a short due date encourages a decision-maker to quote a small due date. Further, we compare the optimal due date in different parameter setting where the penalty coefficient of earliness is negative or zero, which means there is reward or no penalty on earliness, respectively. Finally, a case study is conducted to validate the effectiveness and efficiency of the proposed model.
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| 10. |
- Tao, Liangyan, et al.
(författare)
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Schedule risk analysis for new-product development : The GERT method extended by a characteristic function
- 2017
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Ingår i: Reliability Engineering & System Safety. - : Elsevier BV. - 0951-8320 .- 1879-0836. ; 167, s. 464-473
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Tidskriftsartikel (refereegranskat)abstract
- Schedule risk analysis plays a key role in new product development. A typical project-schedule model using the Critical Path Method (CPM) and Program, Evaluation, and Review Technique (PERT) falls short in many practical situations. Instead, a graphical evaluation and review technique (GERT) has been recommended for its ability to address probability branches and loops. This paper introduces a GERT model based on a characteristic function and designs its numerical solution. First, an inversion formula is applied to derive the probability distribution of the completion time of a product development. Second, to address the implications of a due date, a novel measure of schedule risk is introduced to give a view of both loss and probability. Third, an elasticity analysis is used to identify the network parameters that facilitate the control of schedule risk. A case study of new product development in a high-technology enterprise is presented to demonstrate the proposed methods. The approach will be useful in schedule risk analysis across several problem domains including engineering, environment, management, economic development, etc.
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