| 1. |
- Ji, Qinglei, et al.
(författare)
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A Modular Microfluidic Device via Multimaterial 3D Printing for Emulsion Generation
- 2018
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Ingår i: Scientific Reports. - : Springer Nature. - 2045-2322. ; 8
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Tidskriftsartikel (refereegranskat)abstract
- 3D-printing (3DP) technology has been developing rapidly. However, limited studies on the contribution of 3DP technology, especially multimaterial 3DP technology, to droplet-microfluidics have been reported. In this paper, multimaterial 3D-printed devices for the pneumatic control of emulsion generation have been reported. A 3D coaxial flexible channel with other rigid structures has been designed and printed monolithically. Numerical and experimental studies have demonstrated that this flexible channel can be excited by the air pressure and then deform in a controllable way, which can provide the active control of droplet generation. Furthermore, a novel modular microfluidic device for double emulsion generation has been designed and fabricated, which consists of three modules: function module, T-junction module, and co-flow module. The function module can be replaced by (1) Single-inlet module, (2) Pneumatic Control Unit (PCU) module and (3) Dual-inlet module. Different modules can be easily assembled for different double emulsion production. By using the PCU module, double emulsions with different number of inner droplets have been successfully produced without complicated operation of flow rates of different phases. By using single and dual inlet module, various double emulsions with different number of encapsulated droplets or encapsulated droplets with different compositions have been successfully produced, respectively.
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| 2. |
- Zhang, Jia Ming, et al.
(författare)
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An integrated micro-millifluidic processing system.
- 2018
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Ingår i: Lab on a chip. - : Royal Society of Chemistry. - 1473-0197 .- 1473-0189. ; 18:22, s. 3393-3404
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Tidskriftsartikel (refereegranskat)abstract
- The development of integrated microfluidic systems/platforms concerns many fields. Current remarkable integrated systems based on stacking multi-layer polydimethylsiloxane (PDMS) require complicated fabrication and operation and still remain challenging. We propose a novel micro-millifluidic processing system (MPS) comprising three core modules: a motherboard, a control panel and microfluidic chips. Fluids are handled in sub-millichannels in a motherboard and functional operations occur in microchannels in microfluidic chips. A motherboard with versatile functional units for fluid handling was monolithically fabricated via multimaterial 3D printing, which avoids multi-layer structures, and the major disadvantage of current 3D printing, i.e. low resolution, has been overcome by integrating novel microfluidic chips based on our developed maskless lithography platform. Both numerical and experimental studies were conducted to validate our system. Potential applications such as droplet generation and distribution, microfluidic mixing and simple bacterial resistance tests have been demonstrated via our MPS.
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