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Recent Progress and Future Direction for the Application of Multiomics Data in Clinical Liver Transplantation
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- Liu, Zhengtao (författare)
- Zhejiang Shuren Univ, Shulan Int Med Coll, Hangzhou, Zhejiang, Peoples R China.;Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Surg,Div Hepatobiliary & Pancreat Surg, Hangzhou 310003, Zhejiang, Peoples R China.;Zhejiang Univ, Affiliated Hosp 1, Sch Med,CAMS, NHC Key Lab Combined Multiorgan Transplantat,Key, Hangzhou, Zhejiang, Peoples R China.;Zhejiang Univ, Affiliated Hosp 1, Sch Med, Key Lab Organ Transplantat, Hangzhou, Zhejiang, Peoples R China.
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- Xu, Jun (författare)
- Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Surg,Div Hepatobiliary & Pancreat Surg, Hangzhou 310003, Zhejiang, Peoples R China.
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- Que, Shuping (författare)
- DingXiang Clin, Hangzhou, Zhejiang, Peoples R China.
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- Zhejiang Shuren Univ, Shulan Int Med Coll, Hangzhou, Zhejiang, Peoples R China;Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Surg,Div Hepatobiliary & Pancreat Surg, Hangzhou 310003, Zhejiang, Peoples R China.;Zhejiang Univ, Affiliated Hosp 1, Sch Med,CAMS, NHC Key Lab Combined Multiorgan Transplantat,Key, Hangzhou, Zhejiang, Peoples R China.;Zhejiang Univ, Affiliated Hosp 1, Sch Med, Key Lab Organ Transplantat, Hangzhou, Zhejiang, Peoples R China. Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Surg,Div Hepatobiliary & Pancreat Surg, Hangzhou 310003, Zhejiang, Peoples R China. (creator_code:org_t)
- Xia & He Publishing, 2022
- 2022
- Engelska.
- Ingår i: JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY. - : Xia & He Publishing. - 2225-0719. ; 10:2, s. 363-373
- Forskningsöversikt (refereegranskat)
Abstract
Ämnesord
Stäng
- Omics data address key issues in liver transplantation (LT) as the most effective therapeutic means for end-stage liver disease. The purpose of this study was to review the current application and future direction for omics in LT. We reviewed the use of multiomics to elucidate the pathogenesis leading to LT and prognostication. Future directions with respect to the use of omics in LT are also described based on perspectives of surgeons with experience in omics. Significant molecules were identified and summarized based on omics, with a focus on post-transplant liver fibrosis, early allograft dysfunction, tumor recurrence, and graft failure. We emphasized the importance omics for clinicians who perform LTs and prioritized the directions that should be established. We also outlined the ideal workflow for omics in LT. In step with advances in technology, the quality of omics data can be guaranteed using an improved algorithm at a lower price. Concerns should be addressed on the translational value of omics for better therapeutic effects in patients undergoing LT.
Ämnesord
- NATURVETENSKAP -- Biologi -- Bioinformatik och systembiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Bioinformatics and Systems Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- Multiomic analysis
- Transcriptomics
- Proteomics
- Metabolomics
- Liver transplantation
- EAD
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- Liu, Zhengtao
- Xu, Jun
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- Geng, Lei
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- Mardinoglu, Adil
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- Zheng, Shusen
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