| 1. |
- Liu, Hui Rong, et al.
(författare)
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Relationship of myocardial remodeling to the genesis of serum autoantibodies to cardiac beta(1)-adrenoceptors and muscarinic type 2 acetylcholine receptors in rats.
- 2002
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Ingår i: Journal of the American College of Cardiology. - 0735-1097. ; 39:11, s. 1866-73
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: We sought to investigate the mechanism responsible for the occurrence of anticardiac receptor autoantibodies. BACKGROUND: Increasing evidence suggests the involvement of autoimmune mechanisms in the pathogenesis of a number of cardiovascular diseases. Among them, the biologic, functional and pathogenic properties of anticardiac receptor antibodies have been extensively investigated. However, the mechanism responsible for the occurrence of anticardiac receptor autoantibodies remains poorly understood. METHODS: Two rat models (aortic banding [AB] and adriamycin [ADR] groups) were constructed. Determination of cardiac function and morphology and T-lymphocyte subtypes, enzyme-linked immunosorbent assay and cardiomyocyte cultures were performed. RESULTS: It was shown, in the AB and ADR groups, that the frequency and titer of autoantibodies to beta(1) and muscarinic type 2 receptors were increased when myocardial remodeling occurred, as evidenced by significant cardiac morphologic changes, deposition of collagen and obvious functional impairment. This suggests that cardiac remodeling itself, in two disparate models of heart failure and cardiomyopathy, was able to trigger the genesis of anticardiac receptor autoantibodies. These autoantibodies have biologic effects similar to those seen in human autoantibodies. They have also shown a characteristic self-growth, as well as a time-course decline, suggesting that a negative finding of anticardiac receptor autoantibodies in sera of patients with heart disease does not necessarily imply that there is no autoimmune reaction involved in the pathogenesis. CONCLUSIONS: Our results demonstrated that myocardial damage was able to trigger the occurrence of an autoimmune reaction, resulting in the genesis of anticardiac receptor autoantibodies with properties similar to those seen in patients with idiopathic dilated cardiomyopathy.
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| 2. |
- Azadian, Saied, et al.
(författare)
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Delta Phase Precipitation in Inconel 718
- 2004
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Ingår i: Materials Characterization. - : Elsevier. - 1044-5803 .- 1873-4189. ; :52, s. 7-16
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Tidskriftsartikel (refereegranskat)abstract
- The precipitation and dissolution kinetics of the δ-phase were studied in three wrought versions and one spray-formed (SF) version of the nickel alloy, Inconel 718. The precipitation in the spray-formed version and one wrought version was followed during isothermal ageing for up to 100 h between 700 and 1000 °C. The δ-phase precipitates in the form of nonuniformly distributed thin platelets and an alternative method of measuring volume fraction of this precipitate morphology is proposed. At and above 800 °C, the precipitation was measured quantitatively in terms of the volume fraction and platelet thickness distribution. The maximum rate of precipitation occurred at approximately 900 °C. The solvus temperature lay between 1005 and 1015 °C for Nb contents of 5.06 and 5.41 wt.%, respectively. A study was made of the dissolution of the δ-phase in all four alloys using isochronal treatments and this confirmed the above solvus temperature range. The effect of δ-phase and its dissolution on the grain growth of the alloys was also determined.
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| 3. |
- Azadian, S., et al.
(författare)
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Precipitation in spray-formed IN 718
- 2001
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Ingår i: Superalloys 718, 625, 706 and various derivatives. - Warrendale, Pa : Minerals, Metals & Materials Society. ; , s. 617-626
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Konferensbidrag (refereegranskat)abstract
- The precipitation of the γ', γ'' and δ phases in a spray-formed version of IN 718 has been studied by hardness measurement and metallographic examination of samples subjected to solution treatment at 1025°C followed by isothermal treatments between 620 and 1010°C up to 100 h. The precipitation processes were compared to those in a wrought (ring-rolled) version of the alloy subjected to the same heat treatments. Time-temperature-hardness diagrams for the two alloys were constructed. Small differences were observed between the two materials but these can at least partly be attributed to differences in composition. For the spray-cast material the δ-phase solvus temperature was determined and the growth kinetics of the γ'' phase established
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| 4. |
- Azadian, Saied, et al.
(författare)
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Precipitation in spray-formed IN718
- 2001
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Ingår i: Proceedings of Fifth International Special Emphasis Symposium on Sureralloys. - : The Minerals, Metals, and Materials Society. ; , s. 617-626
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Konferensbidrag (refereegranskat)
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| 5. |
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| 6. |
- Fu, Ying, 1964, et al.
(författare)
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Conductive adhesives
- 2004
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Ingår i: Lead free electronics. ; , s. pp 285-351
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 7. |
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| 8. |
- Fu, Ying, 1964, et al.
(författare)
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Electron conduction through nano particles in electrically conductive adhesives
- 2004
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Ingår i: Micromaterials and Nanomaterials. ; 3, s. 104-
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- We have studied the electron transmission of an electrically conductive adhesive (ECA) composed of micro-size and nano-size metal fillers. By quantum mechanics, it has been shown that due to the quantization of electron states in the nano particle, energy barriers are formed at interconnects between the microfillers and nano particles. The energy barriers effectively reduce the electron transmission through the nano particles. For an ECA consisting of 50-nm-diameter nano particles, the electron conduction is reduced by a factor of 2, and the time for the electron to transmit through the nano particle is about 100 ps.
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