Sökning: WFRF:(Livi Lorenzo)
> (2023) >
Safety profile of t...
Safety profile of trastuzumab-emtansine (T-DM1) with concurrent radiation therapy : A systematic review and meta-analysis
-
- Salvestrini, Viola (författare)
- Careggi University Hospital,University of Florence,Univ Florence, Italy; Azienda Osped Univ Careggi, Italy
-
- Kim, Kyubo (författare)
- Ewha Womans University,University of Florence,Univ Florence, Italy; Ewha Womans Univ, South Korea
-
- Caini, Saverio (författare)
- Institute for Cancer Research, Prevention and Clinical Network (ISPRO),Inst Canc Res Prevent & Clin Network ISPRO, Italy
-
visa fler...
-
- Alkner, Sara (författare)
- Lund University,Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Bröstcancerbehandling,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Breast cancer treatment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital,Skane Univ Hosp, Sweden; Lund Univ, Sweden
-
- Ekholm, Maria (författare)
- Linköpings universitet,Linköping University,Region Jönköping County,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Dept Oncol, Sweden
-
- Skyttä, Tanja (författare)
- Tampere University Hospital,Tampere Univ Hosp, Finland
-
- Becherini, Carlotta (författare)
- University of Florence,Careggi University Hospital,Univ Florence, Italy; Azienda Osped Univ Careggi, Italy
-
- Coles, Charlotte E. (författare)
- University of Cambridge,Univ Cambridge, England
-
- Kaidar-Person, Orit (författare)
- Maastricht University,Sheba Medical Center,Tel-Aviv University,Sheba Med Ctr, Israel; Tel Aviv Univ, Israel; Maastricht Univ, Netherlands
-
- Offersen, Birgitte (författare)
- Aarhus University Hospital,Aarhus Univ Hosp, Denmark
-
- de Azambuja, Evandro (författare)
- Université Libre de Bruxelles (ULB),Univ Libre Bruxelles ULB, Belgium
-
- Visani, Luca (författare)
- Careggi University Hospital,University of Florence,Univ Florence, Italy
-
- Cortes, Javier (författare)
- European University of Madrid,Pangaea Oncology,Int Breast Canc Ctr IBCC, Spain; Univ Europea Madrid, Spain
-
- Harbeck, Nadia (författare)
- University Hospital Munich,LMU Univ Hosp, Germany
-
- Rugo, Hope S. (författare)
- UCSF Helen Diller Family Comprehensive Cancer Center,UCSF Helen Diller Family Comprehens Canc Ctr, CA USA
-
- Isacke, Clare M. (författare)
- Institute of Cancer Research London,Breast Canc Now Res Ctr, England
-
- Marangoni, Elisabetta (författare)
- Curie Institute, Paris,Inst Curie, France
-
- Morandi, Andrea (författare)
- University of Florence,Univ Florence, Italy
-
- Lambertini, Matteo (författare)
- Ospedale Policlinico San Martino,University of Genoa,Univ Genoa, Italy; IRCCS Osped Policlin San Martino, Italy
-
- Poortmans, Philip (författare)
- University of Antwerp,Iridium Netwerk, Belgium; Univ Antwerp, Belgium
-
- Livi, Lorenzo (författare)
- University of Florence,Careggi University Hospital,Univ Florence, Italy; Azienda Osped Univ Careggi, Italy
-
- Meattini, Icro (författare)
- Careggi University Hospital,University of Florence,Univ Florence, Italy; Azienda Osped Univ Careggi, Italy; Univ Florence, Italy
-
visa färre...
-
(creator_code:org_t)
- ELSEVIER IRELAND LTD, 2023
- 2023
- Engelska.
-
Ingår i: Radiotherapy and Oncology. - : ELSEVIER IRELAND LTD. - 0167-8140 .- 1879-0887. ; 186
- Relaterad länk:
-
http://dx.doi.org/10... (free)
-
visa fler...
-
https://liu.diva-por... (primary) (Raw object)
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background and Purpose: In recent years, the treatment landscape for breast cancer has undergone significant advancements, with the introduction of several new anticancer agents. One such agent is trastuzumab emtansine (T-DM1), an antibody drug conjugate that has shown improved outcomes in both early and advanced breast cancer. However, there is currently a lack of comprehensive evidence regarding the safety profile of combining T-DM1 with radiation therapy (RT). In this study, we aim to provide a summary of the available data on the safety of combining RT with T-DM1 in both early and metastatic breast cancer settings. Materials and Methods: This systematic review and meta-analysis project is part of the consensus recommendations by the European Society for Radiotherapy and Oncology (ESTRO) Guidelines Committee on integrating RT with targeted treatments for breast cancer. A thorough literature search was conducted using the PUBMED/MedLine, Embase, and Cochrane databases to identify original studies focusing on the safety profile of combining T-DM1 with RT. Results: After applying eligibility criteria, nine articles were included in the meta-analysis. Pooled data from these studies revealed a high incidence of grade 3 + radionecrosis (17%), while the rates of grade 3 + radiation-related pneumonitis (<1%) and skin toxicity (1%) were found to be very low. Conclusion: Although there is some concern regarding a slight increase in pneumonitis when combining T-DM1 with postoperative RT, the safety profile of this combination was deemed acceptable for locoregional treatment in non-metastatic breast cancer. However, caution is advised when irradiating intracranial sites concurrently with T-DM1. There is a pressing need for international consensus guidelines regarding the safety considerations of combining T-DM1 and RT for breast cancer.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Breast cancer
- Meta-analysis
- Radiotherapy
- Systematic review
- T-DM1
- Trastuzumab emtansine
- Breast cancer; Meta-analysis; Systematic review; Radiotherapy; T-DM1; Trastuzumab emtansine
Publikations- och innehållstyp
- for (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Salvestrini, Vio ...
-
Kim, Kyubo
-
Caini, Saverio
-
Alkner, Sara
-
Ekholm, Maria
-
Skyttä, Tanja
-
visa fler...
-
Becherini, Carlo ...
-
Coles, Charlotte ...
-
Kaidar-Person, O ...
-
Offersen, Birgit ...
-
de Azambuja, Eva ...
-
Visani, Luca
-
Cortes, Javier
-
Harbeck, Nadia
-
Rugo, Hope S.
-
Isacke, Clare M.
-
Marangoni, Elisa ...
-
Morandi, Andrea
-
Lambertini, Matt ...
-
Poortmans, Phili ...
-
Livi, Lorenzo
-
Meattini, Icro
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Cancer och onkol ...
- Artiklar i publikationen
-
Radiotherapy and ...
- Av lärosätet
-
Lunds universitet
-
Linköpings universitet