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- Gifford, Ethan, et al.
(författare)
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Innovating in knowledge-intensive entrepreneurial firms: exploring the effects of a variety of internal and external knowledge sources on goods and service innovations
- 2022
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Ingår i: Industrial and Corporate Change. - : Oxford University Press (OUP). - 0960-6491 .- 1464-3650. ; 31:5, s. 1259-1284
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Tidskriftsartikel (refereegranskat)abstract
- Although knowledge-intensive entrepreneurial firms experiencing high growth and generating innovations are widely acknowledged as important for economic growth, surprisingly little is known about how such firms achieve and maintain a high level of knowledge intensity through which to innovate. Our article further develops the concept of knowledge intensity by proposing that it is augmented by external and internal search activities carried out by the entrepreneurial firm and analyzes how these activities affect innovation performance. We use principal component analysis to derive formal and informal search channels from summated rating scales—measuring reliance on internal and external sources of knowledge—and then use fractional logit regression to explore how these channels relate to a firm’s innovative performance, i.e., the share of innovative goods and services sold. We find that searching via informal channels, and formal channels toward scientific and technological knowledge, improves innovation performance of both goods and services, while searching via formal channels toward market knowledge positively affects only innovative goods. Overall, informal channels matter more than formal channels. Lastly, we find substitution rather than complementarity effects between external and internal search channels in their effect on innovation performance in both goods and services. Thus, we interpret that building up knowledge intensity per se through search matters more for innovation performance than whether search is internally or externally focused. Our work contributes to the growing literature on knowledge-intensive entrepreneurship, to the related literature on new technology-based firms and young innovative firms, and to the general understanding of knowledge intensity at the firm level.
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| 3. |
- Gifford, Ethan, et al.
(författare)
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Variety in founder experience and the performance of knowledge-intensive innovative firms
- 2021
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Ingår i: Journal of evolutionary economics. - : Springer Science and Business Media LLC. - 0936-9937 .- 1432-1386. ; 31:2, s. 677-713
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Tidskriftsartikel (refereegranskat)abstract
- This article contributes with an analysis of the specific linkages between knowledge, innovation and entrepreneurship for industrial dynamics, within the emerging literature upon knowledge-intensive innovative entrepreneurial (KIE) firms. We find a distinct variety in the usefulness of different types of founder experience (single or teams) in the performance of entrepreneurial firms. This variety affects selection in the economy, as measured by the performance of firms in a two-stage process – namely first by analyzing survival over time and then of high growth rates. We do so in order to consider averages/probabilities in the population using Cox regression as well as of the outliers, using quantile regression. We find that on one hand, founders having previously started firms or worked in the same industry are more likely to survive. On the other hand, very high-growth firms have founders who previously started firms or worked in universities. Combining different types of founder experience in KIE firms has a consistently positive relationship with performance both in terms of survival and of growth. Our interpretation is that the variety of founder experience affect selection processes and opportunity recognition in KIE firms and thereby fundamentally affect whether, and to what extent, entrepreneurial actions lead to industrial transformation.
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- Gustafsson, Erik, 1986, et al.
(författare)
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Artistic Education as a Potential Source of Knowledge-Intensive Innovative Entrepreneurship
- 2021
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Ingår i: 22nd CINet Conference - Organising innovation for a sustainable future, 13-15 September 2021.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- This paper explores how artistic education may become a source of knowledge-intensive innovative entrepreneurship (KIE) in the fashion industry. Through an exploratory case study of the Swedish School of Textiles at the University of Borås, Sweden, we examine the varieties of knowledge developed by fashion design students at BA and MA levels, in order to analyse how they relate to artistic innovation and KIE. We systematically analyse programme syllabi and course curricula over time, contrasting these findings with interviews with alumni and academically responsible individuals at the higher education institution. Our findings show that the students develop artistic creativity by acquiring aesthetic knowledge, and that the knowledge development, as taught throughout the education, is aimed for artistic exploration. This exploration is further enhanced through scientific and technological knowledge, acquired through the tight links to research throughout the education. We argue that fashion design students thereby develop varieties of knowledge for artistic exploration and consequent artistic innovation. As such, they can play a crucial role, post-graduation, for the rise of KIE in the fashion industry, if complemented by varieties of knowledge related to market and business.
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| 8. |
- Kumawat, Ashok Kumar, 1982-, et al.
(författare)
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Inhibition of IL17A Using an Affibody Molecule Attenuates Inflammation in ApoE-Deficient Mice
- 2022
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Ingår i: Frontiers in Cardiovascular Medicine. - : Frontiers Media S.A.. - 2297-055X. ; 9
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Tidskriftsartikel (refereegranskat)abstract
- The balance between pro- and anti-inflammatory cytokines released by immune and non-immune cells plays a decisive role in the progression of atherosclerosis. Interleukin (IL)-17A has been shown to accelerate atherosclerosis. In this study, we investigated the effect on pro-inflammatory mediators and atherosclerosis development of an Affibody molecule that targets IL17A. Affibody molecule neutralizing IL17A, or sham were administered in vitro to human aortic smooth muscle cells (HAoSMCs) and murine NIH/3T3 fibroblasts and in vivo to atherosclerosis-prone, hyperlipidaemic ApoE(-/-) mice. Levels of mediators of inflammation and development of atherosclerosis were compared between treatments. Exposure of human smooth muscle cells and murine NIH/3T3 fibroblasts in vitro to alpha IL-17A Affibody molecule markedly reduced IL6 and CXCL1 release in supernatants compared with sham exposure. Treatment of ApoE(-/-) mice with alpha IL-17A Affibody molecule significantly reduced plasma protein levels of CXCL1, CCL2, CCL3, HGF, PDGFB, MAP2K6, QDPR, and splenocyte mRNA levels of Ccxl1, Il6, and Ccl20 compared with sham exposure. There was no significant difference in atherosclerosis burden between the groups. In conclusion, administration of alpha IL17A Affibody molecule reduced levels of pro-inflammatory mediators and attenuated inflammation in ApoE(-/-) mice.
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- Lassen, Astrid Heidemann, 1975, et al.
(författare)
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Promoting Future Sustainable Transition by Overcoming the Openness Paradox in KIE Firms
- 2020
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Ingår i: Sustainability. - : MDPI AG. - 2071-1050. ; 12:24
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Tidskriftsartikel (refereegranskat)abstract
- A key issue for transition to a more sustainable future is how to promote collaboration for innovation amongst multiple diverse partners. However, collaborating for innovation requires that firms overcome the paradox of openness, i.e., they need to be open to collaboration to innovate and at the same time protect their internal knowledge and intellectual assets to appropriate value from their innovations. The aim of this paper is to investigate how knowledge-intensive entrepreneurial (KIE) firms can overcome this paradox—which is an important barrier to future transitions—by choosing a combination of collaborative partners and appropriability strategies that support their ability to create more radical innovations. We analyze a sample of over 2450 KIE firms, drawing from a cross-European survey. Our results indicate how different partners, and different appropriability strategies, are more, or less, relevant to the generation of the radical innovations needed to transform society into one with a sustainable future; university collaboration and the use of formal protection mechanisms seem especially important for such new-to-the-world innovations. Our study includes important policy implications for how to support and promote future sustainable transitions and also establishes a foundation for future lines of research regarding entrepreneurship and sustainable transition.
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