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Management of BK-vi...
Management of BK-virus infection - Swedish recommendations
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- Dalianis, Tina (författare)
- Karolinska Institutet
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- Eriksson, Britt-Marie, Docent, 1952- (författare)
- Uppsala universitet,Infektionssjukdomar
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- Felldin, Marie (författare)
- Sahlgrens Univ Hosp, Transplant Inst, Gothenburg, Sweden
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- Friman, Vanda, 1952 (författare)
- Sahlgrens Univ Hosp, Dept Infect Dis, Gothenburg, Sweden
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- Hammarin, Anna-Lena (författare)
- Unit Lab Dev & Technol Transfer, Publ Hlth Agcy Sweden, Stockholm, Sweden
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- Herthelius, Maria (författare)
- Karolinska Institutet
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- Ljungmang, Per (författare)
- Karolinska Univ Hosp, Dept Cellular Therapy & Allogene Stem Cell Transp, Stockholm, Sweden
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- Mölne, Johan, 1958 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine
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- Wennberg, Lars (författare)
- Karolinska Inst, Dept Clin Sci Intervent & Technol, Stockholm, Sweden;Karolinska Univ Hosp, Dept Transplantat Surg, Stockholm, Sweden
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- Swartling, Lisa (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2019-04-23
- 2019
- Engelska.
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Ingår i: Infectious Diseases. - : TAYLOR & FRANCIS LTD. - 2374-4235 .- 2374-4243. ; 51:7, s. 479-484
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://www.tandfonl...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://gup.ub.gu.se...
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Abstract
Ämnesord
Stäng
- BK-virus (BKV) associated nephropathy (BKVAN) and BKV associated haemorrhagic cystitis (HC) are complications of BKV infection/reactivation in renal and allogeneic haematopoietic stem cell transplantation (HSCT) patients, respectively. The task of how to manage these diseases was given to the chair by the Swedish Reference Group for Antiviral Therapy (RAV). After individual contributions by members of the working group, consensus discussions were held in a meeting on 23 January 2018 arranged by RAV. Thereafter, the recommendations were published in Swedish on November 2018. The current translation to English has been approved by all co-authors. High BKV serum levels suggest an increased risk for BKVAN and potential graft failure. For detection of BKVAN, careful monitoring of BKV DNA levels in serum or plasma is recommended the first year after renal transplantation and when increased creatinine serum levels of unknown cause are observed. Notably, a renal biopsy is mandatory for diagnosis. To reduce the risk for progression of BKVAN, there is no specific treatment, and tailored individual decrease of immunosuppression is recommended. For BKV-HC, BKV monitoring is not recommended, since BK-viruria frequently occurs in HSCT patients and the predictive value of BKV in plasma/serum has not been determined. However, the risk for BKV-HC is higher for patients undergoing myeloablative conditioning, having an unrelated, HLA-mismatched, or a cord blood donor, and awareness of the increased risk and early intervention may benefit the patients. Also for BKV-HC, no specific therapy is available. Symptomatic treatment, e.g. forced diuresis and analgesics could be of use.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- BKV
- transplantation
- immunosuppression
- haemorrhagic cystitis
- BKVAN
- management
- BKV; BKVAN
- haemorrhagic cystitis
- immunosuppression
- management
- transplantation
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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- Av författaren/redakt...
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Dalianis, Tina
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Eriksson, Britt- ...
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Felldin, Marie
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Friman, Vanda, 1 ...
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Hammarin, Anna-L ...
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Herthelius, Mari ...
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Ljungmang, Per
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Mölne, Johan, 19 ...
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Wennberg, Lars
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Swartling, Lisa
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Uppsala universitet
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Karolinska Institutet
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