| 1. |
|
|
| 2. |
- Grip, L, et al.
(författare)
-
Substance P alterations in skin and brain of chronically stressed atopic-like mice
- 2013
-
Ingår i: Journal of the European Academy of Dermatology and Venereology. - : Wiley-Blackwell. - 0926-9959 .- 1468-3083. ; 27:2, s. 199-205
-
Tidskriftsartikel (refereegranskat)abstract
- Background Stress is known to worsen the symptoms of atopic eczema (AE). Substance P is likely to play an important role in the development and pathogenesis of AE. less thanbrgreater than less thanbrgreater thanObjective To examine a possible connection between chronic mild stress and changes in the expression of substance P and its receptor (R) neurokinin (NK) 1 in the skin and stress-related brain regions in NC/Nga atopic-like mice. less thanbrgreater than less thanbrgreater thanMethods The mice were divided into three groups (eight animals per group): SE (stressed eczematous), NSE (non-stressed eczematous) and SC (stressed control). Ears and brains of the mice were investigated using immunohistochemistry and RT-PCR. less thanbrgreater than less thanbrgreater thanResults In the skin, there was a decrease in the number of substance P immunoreactive nerve fibres in SE compared with SC group. RT-PCR showed a strong tendency to an increase in mRNA for NK1R in the skin of SE compared with NSE mice. There was an increase in the number of mast cells and the degree of their degranulation in the SE compared with both other groups. less thanbrgreater than less thanbrgreater thanA decrease in substance P immunoreactivity in medial hippocampus was found in SE compared with NSE animals. In prefrontal cortex and central amygdala, there were no significant differences in substance P immunoreactivity between the three groups. less thanbrgreater than less thanbrgreater thanConclusion Exposure to chronic mild stress in NC/Nga atopic-like mice may result in altered expression patterns of substance P in the skin and hippocampus.
|
|
| 3. |
|
|
| 4. |
- Nordlind, Klas, et al.
(författare)
-
Effect of chronic mild stress on skin and brain in the NC/Nga atopic-like mouse
- 2011
-
Ingår i: JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol 131 Issue S2 (September 2011). - : Nature Publishing Group. ; , s. S116-S116
-
Konferensbidrag (refereegranskat)abstract
- Atopic eczema is often worsened by stress. We have studied the effect of chronic mild stress in the atopic-like NC/Nga mouse strain. The mice were subjected to chronic mild stress for 12 weeks and eczema was induced by applying a mite antigen (Dermatophagoides pteronyssinus) on the ears for the last 4 weeks. The mice were divided into stressed eczematous, non-stressed eczematousand stressed control groups. Serum corticosterone levels were determined at the endpoint of the experiment. The biopsies from skin and brain have been analyzed using immunohistochemistry and RT-PCR. The diameter of the ears was larger in the stressed eczematous group compared to the other groups. Moreover, the corticosterone levels were significantly lower in the stressedeczematous group. The neuromediators being studied are serotonin, its transporter protein, as well as its receptors, and the tachykinin substance P and its receptor neurokinin-1.
|
|
| 5. |
- Rasul, A, et al.
(författare)
-
Serotonergic mechanisms in atopic eczema
- 2014
-
Ingår i: JOURNAL OF INVESTIGATIVE DERMATOLOGY. - 0022-202X. ; 134, s. S15-S15
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)
|
|
| 6. |
|
|
