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Träfflista för sökning "WFRF:(Lothe R. A.) ;srt2:(2015-2019)"

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1.	Bruun, J, et al. (author) Prognostic, predictive, and pharmacogenomic assessments of CDX2 refine stratification of colorectal cancer 2018 In: Molecular oncology. - : Wiley. - 1878-0261 .- 1574-7891. ; 12:9, s. 1639-1655 Journal article (peer-reviewed)
2.	Sveen, A, et al. (author) Colorectal Cancer Consensus Molecular Subtypes Translated to Preclinical Models Uncover Potentially Targetable Cancer Cell Dependencies 2018 In: Clinical cancer research : an official journal of the American Association for Cancer Research. - 1557-3265. ; 24:4, s. 794-806 Journal article (peer-reviewed)
3.	Rosok, B. I, et al. (author) Characterization of early recurrences following liver resection by ALPPS and two stage hepatectomy in patients with colorectal liver-metastases and small future liver remnants; a translational substudy of the LIGRO-RCT 2019 In: HPB. - : ELSEVIER SCI LTD. - 1365-182X .- 1477-2574. ; 21:8, s. 1017-1023 Journal article (peer-reviewed)abstract Background: Associated liver partition and portal vein ligation in staged hepatectomy (ALPPS) is an alternative resection method to portal vein embolization (PVE) in patients with small future liver remnants (FLR) but has been associated with early tumor recurrences. Methods: Twenty-four patients with colorectal liver metastases (CRLM) patients from the randomized multicenter LIGRO trial comparing outcome of ALPPS (n = 13) vs PVE (n = 11) were included in the study. Mutational analyses of the KRAS, NRAS, BRAF, PIC3CA and TP53 genes of the metastases were performed in 21 patients and correlated to early tumor recurrence. Results: Within 12 months, 13 patients experienced recurrences (6 in TSH group and 7 in ALPPS group). Nine of 13 patients with recurrences had mutations in the TP53 gene, while 3 of 8 patients without recurrence carried the same mutation. Only sporadic cases of the other mutations studied were identified. Conclusions: ALPPS did not appear to be associated with higher rate of rapid recurrences than PVE following radical resection of colorectal liver metastases. Mutations in genes associated with negative oncologic outcome after surgical resection most likely play a role for tumor recurrences in these patients.

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Type of publication: journal article (3)

Type of content: peer-reviewed (3)

Author/Editor: Kallioniemi, O (2); Bruun, J (2); Eide, PW (2); Nesbakken, A (2); Lothe, RA (2); Sveen, A (2); show more...; Björnsson, Bergthor (1); Sandström, Per (1); Almeida, R (1); Ramirez, L (1); David, L (1); Barros, R. (1); Pellinen, T (1); Tabernero, J (1); Dienstmann, R (1); Murumagi, A (1); Svindland, A (1); Arjama, M (1); Guren, MG (1); Eilertsen, I (1); Kolberg, M (1); Guinney, J (1); Lothe, R. A. (1); Rosok, B. I. (1); Eilertsen, IA (1); Danielsen, SA (1); Carling, U. (1); Host-Brunsell, T. (1); Brudvik, K. W. (1); Dorenberg, E. (1); Bjombeth, B. A. (1); Kryeziu, K (1); Elez, E (1); Palmer, HG (1); show less...

University: Karolinska Institutet (2); Linköping University (1)

Language: English (3)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

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