| 1. |
- Betancur, Catalina, et al.
(författare)
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Serotonin transporter gene polymorphisms and hyperserotonemia in autistic disorder
- 2002
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Ingår i: Molecular Psychiatry. - : Springer Science and Business Media LLC. - 1359-4184 .- 1476-5578. ; 7:1, s. 67-71
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Tidskriftsartikel (refereegranskat)abstract
- Previous studies have provided conflicting evidence regarding the association of the serotonin transporter (5-HTT) gene with autism. Two polymorphisms have been identified in the human 5-HTT gene, a VNTR in intron 21 and a functional deletion/insertion in the promoter region (5-HTTLPR) with short and long variants.2 Positive associations of the 5-HTTLPR polymorphism with autism have been reported by two family-based studies, but one found preferential transmission of the short allele3 and the other of the long allele.4 Two subsequent studies failed to find evidence of transmission disequilibrium at the 5-HTTLPR locus.5,6 These conflicting results could be due to heterogeneity of clinical samples with regard to serotonin (5-HT) blood levels, which have been found to be elevated in some autistic subjects.7–9 Thus, we examined the association of the 5-HTTLPR and VNTR polymorphisms of the 5-HTT gene with autism, and we investigated the relationship between 5-HTT variants and whole-blood 5-HT. The transmission/disequilibrium test (TDT) revealed no linkage disequilibrium at either loci in a sample of 96 families comprising 43 trios and 53 sib pairs. Furthermore, no significant relationship between 5-HT blood levels and 5-HTT gene polymorphisms was found. Our results suggest that the 5-HTT gene is unlikely to play a major role as a susceptibility factor in autism.
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| 2. |
- Ferrari, Arnaud, et al.
(författare)
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Commissioning of the CLIC Test Facility 3 : Preliminary Phase in 2001
- 2002
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- In the framework of the CLIC studies, we report on the first commissioning period of the CTF3 Preliminary Phase. Extensive tests were carried out on the front-end and the linac in order to measure the beam properties (energy, emittance, Twiss parameters a
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| 3. |
- Ferrari, Arnaud, et al.
(författare)
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Status of the CTF3 commissioning
- 2002
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Ingår i: 8th European Particle Accelerator Conference. ; , s. 491-494
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The Preliminary Phase of the new CLIC Test Facility CTF3 consists of a low-charge demonstration of the electron bunch train combination process on which the CLIC drive beam generation scheme is based. The principle of the combination relies on the injecti
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