| 1. |
|
|
| 2. |
- Amon, B., et al.
(author)
-
From first-order logic to automated word generation for Lyee
- 2003
-
In: Knowledge-Based Systems. - : Elsevier BV. - 0950-7051 .- 1872-7409. ; 16:07-8, s. 413-429
-
Journal article (peer-reviewed)abstract
- A conceptual schema can be viewed as a language to describe the phenomena in a system to be modelled, i.e. a set of derivation rules and integrity constraints as well as a set of event-rules describing the behaviour of an object system. In this paper, we investigate the relationship between the Lyee software requirements concepts with various constructs in conceptual modelling. Within our work we choose the Unified Modelling Language (UML) as a modelling notation for explaining conceptual models. The result obtained models a fully expressive set of UML and First Order Logic constructs mapped into Lyee concepts.
|
|
| 3. |
|
|
| 4. |
- Love, Arthur, et al.
(author)
-
Evolution of hepatitis C virus variants following blood transfusion from one infected donor to several recipients: a long-term follow-up
- 2004
-
In: Journal of General Virology. - : Microbiology Society. - 1465-2099 .- 0022-1317. ; 85:2, s. 441-450
-
Journal article (peer-reviewed)abstract
- Variants of hepatitis C virus (HCV) from a single infected blood donor and 13 viraemic recipients who were traced were examined by sequencing and cloning to determine the extent of virus diversity in hypervariable region 1. Serum-derived viral isolates were studied from the donor when his HCV infection was discovered in 1993, in his recipients that year (0·3–5 years post-transfusion) and 5 years later in the donor and six viraemic recipients who were still alive. Viral variants of broad diversity were readily demonstrated in the baseline samples of the donor (nucleotide p-distance 0·130), but significantly less (P<0·00003) diversity was observed in the recipients' first samples (p-distances within recipients 0·003–0·062). In the first blood samples of the recipients, many of the viral variants identified were closely related to a strain variant from the donor. In follow-up samples drawn 5 years later from the donor and six recipients, the p-distance among donor clones had increased (0·172, P<0·0005) compared with the recipients, who displayed significantly narrower quasispecies (0·011–0·086). A common finding was that recipients of blood components processed from the same donation differed substantially in persisting HCV infectious sequence. Markedly few changes leading to changes of amino acids had occurred during follow-up in four of six recipients. These results question the significance of the development of viral variants as a necessary phenomenon in the evolution of HCV and pathogenesis of the disease.
|
|
| 5. |
- Love, A, et al.
(author)
-
TT virus infections among blood donors in Iceland: prevalence, genotypes, and lack of relationship to serum ALT levels
- 2000
-
In: Transfusion. - : Wiley. - 1537-2995 .- 0041-1132. ; 40:3, s. 306-309
-
Journal article (peer-reviewed)abstract
- BACKGROUND: The TT virus (TTV) is a newly identified blood-borne virus. Its association with disease is still unknown, and screening of blood donors has not been implemented. Several genotypes of the TTV have been identified. STUDY DESIGN AND METHODS: Three hundred seventy healthy blood donors were randomly selected and tested for TTV by the PCR method. Sequencing of a part of the genome was performed to identify various genotypes of the virus. ALT levels were determined in both infected and uninfected individuals. RESULTS: The TT virus (TTV), was detected in the sera of 23 (6.2%) of 370 healthy Icelandic blood donors; this prevalence is lower than that reported in Japan but higher than that in Scotland. The virus was found in all groups over the age of 19. Sequencing and phylogenetic analysis of 202 bp from open reading frame 1 demonstrated genotypes 1b and 2b 2c and genotype 4 isolates, with the latter bearing 89-percent nucleotide homology with other genotype 4 sequences deposited at GenBank. One sample showed a mixed genotype 1b/2c infection. Serum ALT levels were within normal limits in all infected individuals. CONCLUSION: The TTV carrier state does not cause significant liver injury.
|
|
