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- Øvrelid, Lilja, 1978
(författare)
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Argument Differentiation. Soft constraints and data-driven models
- 2008
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The ability to distinguish between different types of arguments is central to syntactic analysis, whether studied from a theoretical or computational point of view. This thesis investigates the influence and interaction of linguistic properties of syntactic arguments in argument differentiation. Cross-linguistic generalizations regarding these properties often express probabil... meristic, or soft, constraints, rather than absolute requirements on syntactic structure. In language data, we observe frequency effects in the realization of syntactic arguments. We propose that argument differentiation can be studied using data-driven methods which directly express the relationship between frequency distributions in language data and linguistic categories. The main focus in this thesis is on the formulation and empirical evaluation of linguistically motivated features for data-driven modeling. Based on differential properties of syntactic arguments in Scandinavian language data, we investigate the linguistic factors involved in argument differentiation from two different perspectives. We study automatic acquisition of the lexical semantic category of animacy and show that statistical tendencies in argument differentiation supports automatic classification of unseen nouns. The classification is furthermore robust, generalizable across machine learning algorithms, as well as scalable to larger data sets. We go on to perform a detailed study of the influence of a range of different linguistic properties, such as animacy, definiteness and finiteness, on argument disambiguation in data-driven dependency parsing of Swedish. By including features capturing these properties in the representations used by the parser, we are able to improve accuracy significantly, and in particular for the analysis of syntactic arguments. The thesis shows how the study of soft constraints and gradience in language can be carried out using data-driven models and argues that these provide a controlled setting where different factors may be evaluated and their influence quantified. By focusing on empirical evaluation, we come to a better understanding of the results and implications of the datadriven models and furthermore show how linguistic motivation in turn can lead to improved computational models.
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- Bhandage, Amol K., 1988-, et al.
(författare)
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GABA-A and NMDA receptor subunit mRNA expression is altered in the caudate but not the putamen of the postmortem brains of alcoholics
- 2014
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Ingår i: Frontiers in Cellular Neuroscience. - : Frontiers. - 1662-5102. ; 8
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Tidskriftsartikel (refereegranskat)abstract
- Chronic consumption of alcohol by humans has been shown to lead to impairment of executive and cognitive functions. Here, we have studied the mRNA expression of ion channel receptors for glutamate and GABA in the dorsal striatum of post-mortem brains from alcoholics (n = 29) and normal controls (n = 29), with the focus on the caudate nucleus that is associated with the frontal cortex executive functions and automatic thinking and on the putamen area that is linked to motor cortices and automatic movements. The results obtained by qPCR assay revealed significant changes in the expression of specific excitatory ionotropic glutamate and inhibitory GABA-A receptor subunit genes in the caudate but not the putamen. Thus, in the caudate we found reduced levels of mRNAs encoding the GluN2A glutamate receptor and the δ, ε, and ρ2 GABA-A receptor subunits, and increased levels of the mRNAs encoding GluD1, GluD2, and GABA-A γ1 subunits in the alcoholics as compared to controls. Interestingly in the controls, 11 glutamate and 5 GABA-A receptor genes were more prominently expressed in the caudate than the putamen (fold-increase varied from 1.24 to 2.91). Differences in gene expression patterns between the striatal regions may underlie differences in associated behavioral outputs. Our results suggest an altered balance between caudate-mediated voluntarily controlled and automatic behaviors in alcoholics, including diminished executive control on goal-directed alcohol-seeking behavior.
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| 4. |
- Vorechovsky, I, et al.
(författare)
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ATM mutations in cancer families
- 1996
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Ingår i: Cancer research. - 0008-5472. ; 56:18, s. 4130-4133
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Tidskriftsartikel (refereegranskat)
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| 5. |
- Pugliatti, M, et al.
(författare)
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A questionnaire for multinational case-control studies of environmental risk factors in multiple sclerosis (EnvIMS-Q)
- 2012
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Ingår i: Acta Neurologica Scandinavica. - : Wiley-Blackwell. - 0001-6314 .- 1600-0404 .- 0065-1427 .- 1600-5449. ; 126:SI, s. 43-50
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Tidskriftsartikel (refereegranskat)abstract
- Objectives - The increasing incidence of multiple sclerosis (MS) worldwide, especially in women, points to the crucial role of environmental and lifestyle risk factors in determining the disease occurrence. An international multicentre case-control study of Environmental Risk Factors In Multiple Sclerosis (EnvIMS) has been launched in Norway, Sweden, Italy, Serbia and Canada, aimed to examine MS environmental risk factors in a large study population and disclose reciprocal interactions. To ensure equivalent methodology in detecting age-related past exposures in individuals with and without MS across the study sites, a new questionnaire (EnvIMS-Q) is presented. Materials and methods - EnvIMS-Q builds on previously developed guidelines for epidemiological studies in MS and is a 6-page self-administered postal questionnaire. Participants are de-identified through the use of a numerical code. Its content is identical for cases and controls including core and population-specific questions as proxies for vitamin D exposure (sun exposure, dietary habits and supplementation), childhood infections (including infectious mononucleosis) and cigarette smoking. Information on possible confounders or effect modifiers is also obtained. EnvIMS-Q was initially drafted in English and subsequently translated into Italian, Serbian, Norwegian, Swedish and French-Canadian. EnvIMS-Q has been tested for acceptability, feasibility and reliability. Results and Conclusions - EnvIMS-Q has shown cross-cultural feasibility, acceptability and reliability in both patients with MS and healthy subjects from all sites. EnvIMS-Q is an efficient tool to ensure proper assessment of age-specific exposure to environmental factors in large multinational population-based case-control studies of MS risk factors.
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- Vorburger, Audrey, et al.
(författare)
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Three‐Dimensional Modeling of Callisto's Surface Sputtered Exosphere Environment
- 2019
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Ingår i: Journal of Geophysical Research - Space Physics. - 2169-9380 .- 2169-9402. ; 124:8, s. 7157-7169
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Tidskriftsartikel (refereegranskat)abstract
- We study the release of various elements from Callisto's surface into its exosphere by plasma sputtering. The cold Jovian plasma is simulated with a 3‐D plasma‐planetary interaction hybrid model, which produces 2‐D surface precipitation maps for magnetospheric H+, O+, O++, and S++. For the hot Jovian plasma, we assume isotropic precipitation onto the complete spherical surface. Two scenarios are investigated: one where no ionospheric shielding takes place and accordingly full plasma penetration is implemented (no‐ionosphere scenario) and one where an ionosphere lets virtually none of the cold plasma but all of the hot plasma reach Callisto's surface (ionosphere scenario). In the 3‐D exosphere model, neutral particles are sputtered from the surface and followed on their individual trajectories. The 3‐D density profiles show that whereas in the no‐ionosphere scenario the ram direction is favored, the ionosphere scenario produces almost uniform density profiles. In addition, the density profiles in the ionosphere scenario are reduced by a factor of ∼2.5 with respect to the no‐ionosphere scenario. We find that the Neutral Gas and Ion Mass Spectrometer, which is part of the Particle Environment Package on board the JUpiter ICy moons Explorer mission, will be able to detect the different sputter populations from Callisto's icy surface and the major sputter populations from Callisto's nonicy surface. The chemical composition of Callisto's exosphere can be directly linked to the chemical composition of its surface and will offer us information not only on Callisto's formation scenario but also on the building blocks of the Jupiter system.
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| 10. |
- Wang, F. H., et al.
(författare)
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Determination of conjugation efficiency of antibodies and proteins to the superparamagnetic iron oxide nanoparticles by capillary electrophoresis with laser-induced fluorescence detection
- 2003
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Ingår i: Journal of nanoparticle research. - 1388-0764 .- 1572-896X. ; 5:02-jan, s. 137-146
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Tidskriftsartikel (refereegranskat)abstract
- The method based on capillary electrophoresis with laser-induced fluorescence detection (CE/LIF) was developed for determination of magnetic iron oxide nanoparticles (hydrodynamic diameters of 100 nm) functionalized with molecules containing primary amino groups. The magnetic nanoparticles with carboxylic or aminopropyltrimethoxysilane groups at their surface were conjugated to the model proteins ( bovine serum albumin, BSA; streptavidin or goat anti-rabbit immunoglobulin G, IgG) using carbodiimide as a zero-length cross-linker. The nanoparticle-protein conjugates ( hydrodynamic diameter 163 - 194 nm) were derivatized with naphthalene-2,3- dicarboxaldehyde reagent and separated by CE/LIF with a helium - cadmium laser ( excitation at 442 nm, emission at 488 nm). The separations were carried out by using a fused-silica capillary ( effective length 48 cm, inner diameter 75 mum) and 100 mM sodium borate buffer ( pH 9.2), the potential was 30 kV. The detection limit for BSA-conjugate was 1.3 pg/10 nl, i.e. about 20 amol. The present method provides an efficient and fast tool for sensitive determination of the efficacy of biomolecular functionalization of magnetic nanoparticles. The CE/LIF technique requires only negligible sample volumes for analysis, which is especially suitable for controlling the process of preparation of functionalized nanoparticles with unique properties aimed to be used for diagnostic or therapeutic purposes.
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