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Multi-omic biomarke...
Multi-omic biomarker identification and validation for diagnosing warzone-related post-traumatic stress disorder
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- Dean, Kelsey R. (författare)
- Harvard University
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- Hammamieh, Rasha (författare)
- US Army Medical Research and Materiel Command
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- Mellon, Synthia H. (författare)
- University of California, San Francisco
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- Abu-Amara, Duna (författare)
- NYU Langone
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- Flory, Janine D. (författare)
- Icahn School of Medicine at Mount Sinai,James J. Peters Veterans Administration Medical Center
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- Guffanti, Guia (författare)
- McLean Hospital
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- Wang, Kai (författare)
- Institute for Systems Biology, Seattle
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- Daigle, Bernie J. (författare)
- University of Memphis
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- Gautam, Aarti (författare)
- US Army Medical Research and Materiel Command
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- Lee, Inyoul (författare)
- Institute for Systems Biology, Seattle
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- Yang, Ruoting (författare)
- National Cancer Institute at Frederick
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- Almli, Lynn M. (författare)
- Emory University
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- Bersani, F. Saverio (författare)
- University of California, San Francisco,Sapienza University of Rome
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- Chakraborty, Nabarun (författare)
- U.S. Army Center for Environmental Health Research
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- Donohue, Duncan (författare)
- U.S. Army Center for Environmental Health Research
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- Kerley, Kimberly (författare)
- Emory University
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- Kim, Taek Kyun (författare)
- Institute for Systems Biology, Seattle
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- Laska, Eugene (författare)
- NYU Langone
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- Young Lee, Min (författare)
- Institute for Systems Biology, Seattle
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- Lindqvist, Daniel (författare)
- Lund University,Lunds universitet,Enheten för klinisk suicidforskning,Forskargrupper vid Lunds universitet,Enheten för Biologisk Psykiatri och Precisionspsykiatri,Unit for clinical suicide research,Lund University Research Groups,Unit for Biological and Precision Psychiatry,University of California, San Francisco
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- Lori, Adriana (författare)
- Emory University
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- Lu, Liangqun (författare)
- University of Memphis
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- Misganaw, Burook (författare)
- Harvard University
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- Muhie, Seid (författare)
- U.S. Army Center for Environmental Health Research
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- Newman, Jennifer (författare)
- NYU Langone
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- Price, Nathan D. (författare)
- Institute for Systems Biology, Seattle
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- Qin, Shizhen (författare)
- Institute for Systems Biology, Seattle
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- Reus, Victor I. (författare)
- University of California, San Francisco
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- Siegel, Carole (författare)
- NYU Langone
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- Somvanshi, Pramod R. (författare)
- Harvard University
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- Thakur, Gunjan S. (författare)
- Harvard University
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- Zhou, Yong (författare)
- Institute for Systems Biology, Seattle
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- Hood, Leroy (författare)
- Institute for Systems Biology, Seattle
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- Ressler, Kerry J. (författare)
- McLean Hospital
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- Wolkowitz, Owen M. (författare)
- University of California, San Francisco
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- Yehuda, Rachel (författare)
- Icahn School of Medicine at Mount Sinai,James J. Peters Veterans Administration Medical Center
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- Jett, Marti (författare)
- U.S. Army Center for Environmental Health Research
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- Doyle III, Francis J. (författare)
- Harvard University
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- Marmar, Charles (författare)
- New York University,NYU Langone
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(creator_code:org_t)
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- 2019-09-10
- 2020
- Engelska 13 s.
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Ingår i: Molecular Psychiatry. - : Springer Science and Business Media LLC. - 1359-4184 .- 1476-5578. ; 25:12, s. 3337-3349
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://www.nature.c...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Post-traumatic stress disorder (PTSD) impacts many veterans and active duty soldiers, but diagnosis can be problematic due to biases in self-disclosure of symptoms, stigma within military populations, and limitations identifying those at risk. Prior studies suggest that PTSD may be a systemic illness, affecting not just the brain, but the entire body. Therefore, disease signals likely span multiple biological domains, including genes, proteins, cells, tissues, and organism-level physiological changes. Identification of these signals could aid in diagnostics, treatment decision-making, and risk evaluation. In the search for PTSD diagnostic biomarkers, we ascertained over one million molecular, cellular, physiological, and clinical features from three cohorts of male veterans. In a discovery cohort of 83 warzone-related PTSD cases and 82 warzone-exposed controls, we identified a set of 343 candidate biomarkers. These candidate biomarkers were selected from an integrated approach using (1) data-driven methods, including Support Vector Machine with Recursive Feature Elimination and other standard or published methodologies, and (2) hypothesis-driven approaches, using previous genetic studies for polygenic risk, or other PTSD-related literature. After reassessment of ~30% of these participants, we refined this set of markers from 343 to 28, based on their performance and ability to track changes in phenotype over time. The final diagnostic panel of 28 features was validated in an independent cohort (26 cases, 26 controls) with good performance (AUC = 0.80, 81% accuracy, 85% sensitivity, and 77% specificity). The identification and validation of this diverse diagnostic panel represents a powerful and novel approach to improve accuracy and reduce bias in diagnosing combat-related PTSD.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
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Till lärosätets databas
- Av författaren/redakt...
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Dean, Kelsey R.
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Hammamieh, Rasha
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Mellon, Synthia ...
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Abu-Amara, Duna
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Flory, Janine D.
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Guffanti, Guia
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visa fler...
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Wang, Kai
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Daigle, Bernie J ...
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Gautam, Aarti
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Lee, Inyoul
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Yang, Ruoting
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Almli, Lynn M.
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Bersani, F. Save ...
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Chakraborty, Nab ...
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Donohue, Duncan
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Kerley, Kimberly
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Kim, Taek Kyun
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Laska, Eugene
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Young Lee, Min
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Lindqvist, Danie ...
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Lori, Adriana
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Lu, Liangqun
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Misganaw, Burook
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Muhie, Seid
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Newman, Jennifer
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Price, Nathan D.
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Qin, Shizhen
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Reus, Victor I.
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Siegel, Carole
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Somvanshi, Pramo ...
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Thakur, Gunjan S ...
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Zhou, Yong
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Hood, Leroy
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Ressler, Kerry J ...
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Wolkowitz, Owen ...
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Yehuda, Rachel
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Jett, Marti
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Doyle III, Franc ...
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Marmar, Charles
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Psykiatri
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Cell och molekyl ...
- Artiklar i publikationen
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Molecular Psychi ...
- Av lärosätet
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Lunds universitet