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Träfflista för sökning "WFRF:(Lu Zhiyong) srt2:(2015-2019)"

Sökning: WFRF:(Lu Zhiyong) > (2015-2019)

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1.
  • 2019
  • Tidskriftsartikel (refereegranskat)
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2.
  • Han, Zhiyong, et al. (författare)
  • Extreme monsoon aridity episodes recorded in South China during Heinrich Events
  • 2015
  • Ingår i: Palaeogeography, Palaeoclimatology, Palaeoecology. - : Elsevier BV. - 0031-0182 .- 1872-616X. ; 440, s. 467-474
  • Tidskriftsartikel (refereegranskat)abstract
    • Geological records of climate change since the last glaciation in South China, a core area of the East Asian monsoon, are key to understanding secular variation in the monsoon system. However, with the exception of the speleothems, records from this area with independent age control are few. We investigated aeolian sand deposition on a sand hill on the shore of Poyang Lake in South China and reconstructed the chronological sequence of aeolian deposition using Optically Stimulated Luminescence (OSL) dating. Without exception, all aeolian sediments were deposited within seven periods that generally match the timing of Heinrich events and other cold periods in Greenland. We argue that aeolian sand accumulation in this region is most likely forced by extreme aridity driven by weakening of the summer monsoon, while the characteristics of this deposition are influenced by winter monsoon intensity. The monsoon shifts revealed here suggest a possible link between North Atlantic cooling and summer monsoon strength in South China, and support the intensities of cooling phases recorded in Greenland ice cores.
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3.
  • Makafe, Gaelle G., et al. (författare)
  • Quinoline Derivatives Kill Mycobacterium tuberculosis by Activating Glutamate Kinase
  • 2019
  • Ingår i: Cell Chemical Biology. - : CELL PRESS. - 2451-9456 .- 2451-9448. ; 26:8, s. 1187-
  • Tidskriftsartikel (refereegranskat)abstract
    • There is a great need for identification and development of new anti-tuberculosis drugs with novel targets. Recent drug-discovery efforts typically focus on identifying inhibitors but not activators that perturb metabolic enzymes' functions as a means to kill Mycobacterium tuberculosis (Mtb). Here, we describe a class of quinoline compounds, Z0933/Z0930, which kill Mtb by acting as activators of glutamate kinase (GK), a previously untargeted enzyme catalyzing the first step of proline biosynthesis. We further show that Z0933/Z0930 augment proline production and induce Mtb killing via proline-derived redox imbalance and production of reactive oxygen species. This work highlights the effectiveness of gain-of-function probes against Mtb and provides a framework for the discovery of next-generation allosteric activators of GK.
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