| 1. |
- Ludvigsson, Jonas F., et al.
(författare)
-
Coeliac disease in the father affects the newborn
- 2001
-
Ingår i: Gut. - : BMJ. - 0017-5749 .- 1468-3288. ; 49:2, s. 169-175
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND AND AIMS Untreated coeliac disease in the mother is associated with lower birth weight. We examined the risk of adverse neonatal outcome when the infant's mother, father, or other relative suffered from known coeliac disease.METHODS Mothers answered a questionnaire a few days after the birth of their infant. Of a total of 10597 single birth infants from Southeast Sweden, 53 infants had a mother with coeliac disease (father 27, sibling 70, other close relative 442). Adjusted odds ratios and adjusted differences for neonatal outcome were calculated.RESULTS Infants whose father suffered from coeliac disease had a lower birth weight (95% adjusted confidence interval (CI) −459, −72 g), more often belonged to the low birth weight (LBW) category (LBW ⩽2499 g) (95% CI adjusted odds ratio (AOR) 1.48–17.18), and had a shorter pregnancy duration (95% adjusted CI −1.53, −0.08 weeks) than non-coeliac controls. They also weighed less than infants whose father suffered from other autoimmune diseases (95% CI −549, −93 g). Infants whose mother suffered from coeliac disease had a lower birth weight (95% adjusted CI −370, −74 g) and more often belonged to the LBW category (95% CI AOR 2.60–15.08) than non-coeliac controls. These infants were more often in the LBW category than infants whose mother suffered from non-diabetic autoimmune diseases (95% CI AOR 1.24–9.65). Coeliac disease in other relatives was not associated with any adverse effect on neonatal outcome.CONCLUSIONS This study suggests that even treated coeliac disease, in either of the parents, has a negative effect on pregnancy, resulting in lower birth weight and perhaps shorter duration of pregnancy.
|
|
| 2. |
- Ludvigsson, Jonas F., 1943-, et al.
(författare)
-
Milk consumption during pregnancy and infant birthweight
- 2004
-
Ingår i: Acta Paediatrica. - 0803-5253 .- 1651-2227. ; 93:11, s. 1474-1478
-
Tidskriftsartikel (refereegranskat)abstract
- Aim: To examine the risk of low birthweight (>2500 g, LBW), intrauterine growth retardation (IUGR) and preterm birth (gestational age >37wk) in relation to milk intake.Methods: Observational study in southeast Sweden. Questionnaires were used to collect data on milk consumption during pregnancy and infant birthweight from mother-infant pairs during a 2-y period as part of the ABIS (All Babies in Southeast Sweden) study. Data on IUGR were obtained through the Swedish medical birth registry.Results: Adjusting for confounders, low milk intake during pregnancy was associated with an increased risk of IUGR (p= 0.019; n= 12880). LBW (p= 0.191) and preterm birth (p= 0.921) were not associated with milk intake during pregnancy.Conclusion: This study indicates that low milk intake in the pregnant mother may be associated with IUGR of the newborn. We cannot exclude the possibility that the correlation found between milk consumption and intrauterine growth may be due to undetected confounders. Hence, further research is needed to evaluate the relationship between low milk intake, birthweight and risk of IUGR.
|
|
| 3. |
- Ludvigsson, Jonas F, et al.
(författare)
-
Tissue Transglutaminase Auto-antibodies in Cord Blood from Children to Become Celiacs
- 2001
-
Ingår i: Scandinavian Journal of Gastroenterology. - : Informa UK Limited. - 0036-5521 .- 1502-7708. ; 36:12, s. 1279-1283
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Determination of tissue transglutaminase auto-antibodies (tTGAA) has been shown to be a sensitive and specific diagnostic tool for large-scale screening for celiac disease. The purpose of this study was to measure tissue tTGAA in cord blood in infants that later developed celiac disease to evaluate if this assay could serve as a predictive tool for later development of celiac disease.Methods: IgG tTGAA were analyzed in cord blood through immunoprecipitation from 51 future celiac patients and 102 age-matched controls. Cut-off level was set at 0.040.Results: No difference in tTGAA levels was found between cord blood from infants who later developed celiac disease and controls ( P = 0.746). 2/51 future celiac patients (3.9%) had levels above cut-off-value in cord blood, while 3/102 controls were positive (2.9%) ( P = 1.000). tTGAA levels were higher in the 1980s and at the beginning of the 1990s than they have been in recent years ( P = 0.003).Conclusions: Determination of tissue tTGAA in cord blood does not predict future celiac disease in children. tTGAA levels vary with time, which should be considered in retrospective studies analyzing tTGAA.
|
|
| 4. |
- Ludvigsson, Jonas F
(författare)
-
Effect on neonatal outcome.
- 2001
-
Ingår i: European Journal of Clinical Microbiology and Infectious Diseases. - 0934-9723 .- 1435-4373. ; 20, s. 843-849
-
Tidskriftsartikel (refereegranskat)
|
|
| 5. |
- Ludvigsson, Jonas F, et al.
(författare)
-
Missgynna inte forskande ST-läkare!
- 2003
-
Ingår i: Läkartidningen. - Stockholm : Sveriges läkarförbund. - 0023-7205 .- 1652-7518. ; 100:40, s. 3162-3165
-
Tidskriftsartikel (refereegranskat)
|
|
| 6. |
- Ludvigsson, Jonas F.
(författare)
-
Some epidemiological aspects of perinatal gastrointestinal disease
- 2001
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- [Respondenten]Hör upp alla männ'skor t trakten.Ni är bjudna att delta i spikningsakten.Nu vill jag er informeraoch min avhandling summera.Sex studier av skilda slag,en restumé i form av vers, inget föredrag.Studie ett till fem bygger på barn i tusental,cirka tio, födda nittisju, nittiåtta eller nittnio.(Förutsatt förstås att deras mor har haft sitt härbärge,Någonstans uti sydöstra Sverige.)Låt oss gå från helhet till detalj,och följa en genomsnittsfamilj, en ömsint kvmna och en kanalj.Akt I Förlossningssalen.[Barnet] Efter graviditeten fyrti veckor långbörjar jordelivet efter passage så fasligt trång.Där står pappa glad och lermot mor och mig, [Far] -Åh, vad jag älskar er![Far] Men nu kära mor är det dags att fylla i enkäten(!),hur du har haft det under "graviditäten".Har du och jag nå'n sjukdom, kanske "gluten"?(undrar barnets far, den långe drasuten)(Mor] Gluten, nu har jag änligen fått klämpå varför vårt barn vägde mindre än "två och fem"!Även om du varit noga med aptiten,är det nog tarminflammationen din som gjort'en liten![Far] (Pekar på mor) En annan orsak kan vara böldema dina l tarme,[Mor] liten av ulcerös koliten, å gud forbarme![Far] och säger far, att sonen fötts för tidigt, var det gastroenteriten?Du Vet i fjärde måna'n hade du problem med "skiten"![Mor] Men sonen var blott tidig med en enda da'?![Far] Men det var ju det han Ludvigsson sa!Akt II Förlossningssalen. Barnmorska gör entré.[Barnmorska] Ligg ner kära mor, ni är blek som ett lärft!Det är även barnet, kan det vara något han ärvt? (Väntar inte på svar, vänder sig till mor)Att ha ont, att må illa är snarast kutym.[Mor] Tack jag mår bra men hur är det med antikroppsmängd mot transglutaminas-enzym?[Barnmorska] Det är svårt att säga, men den kanske växlar under loppet av ett år, jag tror Ludvigsson fått upp ett spår![Respondenten]Då lämnar vi patient, barn, far och barnmorskeintendenten.Det var allt för denna gång från den unge respondenten.
|
|
