| 1. |
- Allard, F, et al.
(författare)
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Model atmospheres and spectra: The role of dust
- 2003
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Ingår i: Proceedings of the International Astronomical Union (Brown Dwarfs). - 0074-1809. - 158381132X ; 211, s. 325-332
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Konferensbidrag (refereegranskat)abstract
- Brown dwarf atmospheres form molecules, then high temperature condensates (corundum, titanates, silicates, and iron compounds), and then low temperature condensates (ices) as they cool down over time. These produce large opacities which govern entirely their spectral energy distribution. Just as it is important to know molecular opacities (TiO, H2O, CH4, etc.) with accuracy, it is imperative to understand the interplay of processes (e.g. condensation, sedimentation, coagulation, convection) that determines the radial and size distribution of grains. Limiting case models have shown that young, hot brown (L) dwarfs form dust mostly in equilibrium, while at much cooler stages (late T dwarfs) all high temperature condensates have sedimented out of their photospheres. But this process is gradual and all intermediate classes of brown dwarfs can partly be understood in terms of partial sedimentation of dust. With new models accounting for these processes, we describe the effects they may have upon brown dwarf spectral properties.
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| 2. |
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| 3. |
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| 4. |
- Kassner, A, et al.
(författare)
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Molecular structure and interaction of recombinant human type XVI collagen
- 2004
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Ingår i: Journal of Molecular Biology. - : Elsevier BV. - 1089-8638 .- 0022-2836. ; 339:4, s. 835-853
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Tidskriftsartikel (refereegranskat)abstract
- Collagen XVI is a minor component of at least two different extracellular fibrillar networks of specialized regions of skin and cartilage. In skin, collagen XVI is integrated into particular fibrillin-rich microfibrils lacking an amorphous elastin core. In cartilage, collagen XVI is a component of small heterotypic D-banded fibrils, mainly occurring in the territorial matrix of chondrocytes. Here, we present the first direct evidence for the molecular structure and functional properties of these fibril-associated collagens with interrupted triple helices (FACIT). We have expressed recombinantly the full-length alpha1 chain of human collagen XVI in HEK 293 EBNA cells in large quantities using an episomal expression system. Secreted full-length recombinant collagen XVI forms stable disulfide-bonded homotrimers and is rapidly proteolytically processed to distinct fragments at specific protease sequence motifs, one resembling an aggrecanase recognition site. Limited trypsin digestion assays and thermal transition curves imply sequential thermal denaturation of individual triple helical domains of this recombinant collagen, similar to authentic collagen XVI. Molecular images of collagen XVI reveal rod-like molecules which harbor multiple sharp kinks attributing a highly flexible structure presumably introduced by non-collagenous (NC) regions. Terminally located cloverleaf-shaped nodules correspond to the large NC NC11 domain of trimeric collagen XVI. The total length of individual trimeric recombinant collagen XVI molecules constitutes about 240 nm as calculated by atomic force and negative staining electron microscopy. Recombinant collagen XVI interacts with fibrillin-1 and with fibronectin indicating multiple molecular interactions in which this ubiquitously expressed and versatile FACIT-collagen can participate. In vitro generated collagen XVI provides an indispensable tool for future determination of its function during supramolecular assembly of matrix aggregates and its role in maintenance, organization and interaction of fibrillar structures. (C) 2004 Elsevier Ltd. All rights reserved.
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| 5. |
- Kyle, RA, et al.
(författare)
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Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group
- 2003
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Ingår i: British Journal of Haematology. - : Wiley. - 0007-1048. ; 121:5, s. 749-757
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Tidskriftsartikel (refereegranskat)abstract
- The monoclonal gammopathies are a group of disorders associated with monoclonal proliferation of plasma cells. The characterization of specific entities is an area of difficulty in clinical practice. The International Myeloma Working Group has reviewed the criteria for diagnosis and classification with the aim of producing simple, easily used definitions based on routinely available investigations. In monoclonal gammopathy of undetermined significance (MGUS) or monoclonal gammopathy, unattributed/unassociated (MG[u]), the monoclonal protein is < 30 g/l and the bone marrow clonal cells < 10% with no evidence of multiple myeloma, other B-cell proliferative disorders or amyloidosis. In asymptomatic (smouldering) myeloma the M-protein is greater than or equal to 30 g/l and/or bone marrow clonal cells greater than or equal to 10% but no related organ or tissue impairment (ROTI)(end-organ damage), which is typically manifested by increased calcium, renal insufficiency, anaemia, or bone lesions (CRAB) attributed to the plasma cell proliferative process. Symptomatic myeloma requires evidence of ROTI. Non-secretory myeloma is characterized by the absence of an M-protein in the serum and urine, bone marrow plasmacytosis and ROTI. Solitary plasmacytoma of bone, extramedullary plasmacytoma and multiple solitary plasmacytomas (+/- recurrent) are also defined as distinct entities. The use of these criteria will facilitate comparison of therapeutic trial data. Evaluation of currently available prognostic factors may allow better definition of prognosis in multiple myeloma.
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| 6. |
- Rieutord, M, et al.
(författare)
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A simulation of solar convection at supergranulation scale
- 2002
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Ingår i: Nuovo Cimento C. Colloquia on Physics. - 1124-1896. ; 25:5-6, s. 523-528
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Tidskriftsartikel (refereegranskat)abstract
- We present here numerical simulations of surface solar convection which cover a box of 30 x 30 x 3.2 Mm(3) with a resolution of 315 x 315 x 82, which is used to investigate the dynamics of scales larger than granulation. No structure resembling supergranulation is present; possibly higher Reynolds numbers (i.e. higher numerical resolution), or magnetic fields, or greater depth are necessary. The results also show interesting aspects of granular dynamics which are briefly presented, like extensive p-mode ridges in the k-w diagram and a ringlike distribution of horizontal vorticity around granules. At large scales, the horizontal velocity is much larger than the vertical velocity and the vertical motion is dominated by p-mode oscillations.
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| 7. |
- Rieutord, M, et al.
(författare)
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Are granules good tracers of solar surface velocity fields?
- 2001
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Ingår i: Astronomy & Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 377, s. 14-17
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Tidskriftsartikel (refereegranskat)abstract
- Using a numerical simulation of compressible convection with radiativetransfer mimicking the solar photosphere, we compare the velocity fieldderived from granule motions to the actual velocity field of the plasma.We thus test the idea that granules may be used to trace large-scalevelocity fields at the sun's surface. Our results show that this isindeed the case provided the scale separation is sufficient. We thusestimate that neither velocity fields at scales less than 2500 km nortime evolution at scales shorter than 0.5 hr can be faithfully describedby granules. At larger scales the granular motions correlate linearlywith the underlying fluid motions with a slope of ≲2 reachingcorrelation coefficients up to ~ 0.9.
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