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- André, Ingemar, et al.
(författare)
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The role of electrostatic interactions in calmodulin-peptide complex formation
- 2004
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Ingår i: Biophysical Journal. - : Elsevier BV. - 1542-0086 .- 0006-3495. ; 87:3, s. 1929-1938
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Tidskriftsartikel (refereegranskat)abstract
- The complex between calmodulin and the calmodulin-binding portion of smMLCKp has been studied. Electrostatic interactions have been anticipated to be important in this system where a strongly negative protein binds a peptide with high positive charge. Electrostatic interactions were probed by varying the pH in the range from 4 to 11 and by charge deletions in CaM and smMLCKp. The change in net charge of CaM from similar to-5 at pH 4.5 to -15 at pH 7.5 leaves the binding constant virtually unchanged. The affinity was also unaffected by mutations in CaM and charge substitutions in the peptide. The insensitivity of the binding constant to pH may seem surprising, but it is a consequence of the high charge on both protein and peptide. At low pH it is further attenuated by a charge regulation mechanism. That is, the protein releases a number of protons when binding the positively charged peptide. We speculate that the role of electrostatic interactions is to discriminate against unbound proteins rather than to increase the affinity for any particular target protein.
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- Björkegren, C, et al.
(författare)
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Learning for short or long term?
- 2000
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Ingår i: Paper presented at the 16th EGOS Colloquium, Helsinki, July 2-4, 2000.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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- Cherepov, Sergiy, et al.
(författare)
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Micromagnetics of Spin-Flop Bilayers : S, C, and Vortex Spin States
- 2010
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Ingår i: IEEE transactions on magnetics. - 0018-9464 .- 1941-0069. ; 46:6, s. 2124-2127
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Tidskriftsartikel (refereegranskat)abstract
- Spin-flop tunnel junctions subjected to strong gigahertz excitations are found to exhibit highly stable resistance states, intermediate between the two spin-uniform ground states of high and low resistance. The associated spin distributions are necessarily nonuniform and differ significantly from the ground-state anti-parallel spin configuration in their static and dynamic properties. Detailed micromagnetic modeling reveals that inplane spin vortices in dipole-coupled thin-film bilayers are stable spin configurations, where the orientation of the vortex cores and the vortex chirality play an important role in the response of the system to external magnetic fields.
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- Drummond, M. V., et al.
(författare)
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Novel opto-electrical tunable dispersion compensator for IM signals
- 2009
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Ingår i: 2009 35th European Conference on Optical Communication (ECOC). - : VDE Verlag GmbH. - 9783800731732 ; , s. 5287374-
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Konferensbidrag (refereegranskat)abstract
- A novel opto-electrical tunable dispersion compensator with a tuning time lower than 150 s is proposed and experimentally demonstrated. Compensation of 0-340 ps/nm for a 40 Gb/s NRZ signal is achieved.
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- Faia, Ricardo, et al.
(författare)
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Local Electricity Markets for Electric Vehicles: An Application Study Using a Decentralized Iterative Approach
- 2021
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Ingår i: Frontiers in Energy Research. - : Frontiers Media SA. - 2296-598X. ; 9
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Tidskriftsartikel (refereegranskat)abstract
- Local electricity markets are emerging solutions to enable local energy trade for the end users and provide grid support services when required. Various models of local electricity markets (LEMs) have been proposed in the literature. The peer-to-peer market model appears as a promising structure among the proposed models. The peer-to-peer market structure enables electricity transactions between the players in a local energy system at a lower cost. It promotes the production from the small low–carbon generation technologies. Energy communities can be the ideal place to implement local electricity markets as they are designed to allow for larger growth of renewable energy and electric vehicles, while benefiting from local transactions. In this context, a LEM model is proposed considering an energy community with high penetration of electric vehicles in which prosumer-to-vehicle (P2V) transactions are possible. Each member of the energy community can buy electricity from the retailer or other members and sell electricity. The problem is modeled as a mixed-integer linear programing (MILP) formulation and solved within a decentralized and iterative process. The decentralized implementation provides acceptable solutions with a reasonable execution time, while the centralized implementation usually gives an optimal solution at the expense of reduced scalability. Preliminary results indicate that there are advantages for EVs as participants of the LEM, and the proposed implementation ensures an optimal solution in an acceptable execution time. Moreover, P2V transactions benefit the local distribution grid and the energy community.
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