| 1. |
- Armbrecht, John, et al.
(författare)
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Swedish Sports Clubs and Events during the Covid-19 Pandemic: Impacts and Responses
- 2021
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Ingår i: Crisis Management and Recovery for Events: Impacts and Strategies. - Oxford : Goodfellow Publishers. - 9781911635901 ; , s. 193-212
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Bokkapitel (refereegranskat)abstract
- Sweden has 10 million inhabitants of which more than 30% are members of at least one sports club. Typically, sports clubs are organized under the Swedish Sports Confederation (Riksidrottsförbundet). On a national level, approximately 19,000 sports clubs exist, distributed over 72 specialist sports federations. Each club usually stages one or several sport events every year. For example, specialist sports federations organize all championships at national and international levels. From a sports club perspective, these events constitute important sources of income. From a societal perspective, clubs and events create considerable economic impacts, foster public health, and facilitate integration contributing with substantial social values (Brown et al., 2015; Pettersson & Wallstam, 2017; Wallstam, Ioannides, & Pettersson, 2020). During the Covid-19 pandemic, most governments restricted individuals’ possibilities for gatherings and movements. On March 12th the Swedish government responded to the pandemic by limiting the number of participants to events to no more than 500 people. Starting March 29th gatherings were limited to 50 people. During the end of year 2020 and the second virus wave, further actions were taken. The government limited the number of visitors and participants to eight people. These restrictions had considerable negative effects on many sport-related activities, events, and thus clubs.
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| 2. |
- Borgmästars, Emmy, et al.
(författare)
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Circulating tissue polypeptide-specific antigen in pre-diagnostic pancreatic cancer samples
- 2021
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Ingår i: Cancers. - : MDPI. - 2072-6694. ; 13:21
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Tidskriftsartikel (refereegranskat)abstract
- Early detection of pancreatic ductal adenocarcinoma (PDAC) is challenging, and late diagnosis partly explains the low 5-year survival. Novel and sensitive biomarkers are needed to enable early PDAC detection and improve patient outcomes. Tissue polypeptide specific antigen (TPS) has been studied as a biomarker in PDAC diagnostics, and it has previously been shown to reflect clinical status better than the ‘golden standard’ biomarker carbohydrate antigen 19-9 (CA 19-9) that is most widely used in the clinical setting. In this cross-sectional case-control study using pre-diagnostic plasma samples, we aim to evaluate the potential of TPS as a biomarker for early PDAC detection. Furthermore, in a subset of individuals with multiple samples available at different time points before diagnosis, a longitudinal analysis was used. We assessed plasma TPS levels using enzyme-linked immunosorbent assay (ELISA) in 267 pre-diagnostic PDAC plasma samples taken up to 18.8 years before clinical PDAC diagnosis and in 320 matched healthy controls. TPS levels were also assessed in 25 samples at PDAC diagnosis. Circulating TPS levels were low both in pre-diagnostic samples of future PDAC patients and in healthy controls, whereas TPS levels at PDAC diagnosis were significantly increased (odds ratio 1.03; 95% confidence interval: 1.01–1.05) in a logistic regression model adjusted for age. In conclusion, TPS levels increase late in PDAC progression and hold no potential as a biomarker for early detection.
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| 3. |
- Ekholm, David, 1980-, et al.
(författare)
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Rättighetsarbete med egen erfarenhet som grund
- 2023
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Ingår i: De sociala rättigheternas politik. - Malmö : Gleerups Utbildning AB. - 9789151109855 ; , s. 203-220
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 4. |
- Mason, James E., et al.
(författare)
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A cross-sectional and longitudinal analysis of pre-diagnostic blood plasma biomarkers for early detection of pancreatic cancer
- 2022
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Ingår i: International Journal of Molecular Sciences. - : MDPI. - 1661-6596 .- 1422-0067. ; 23:21
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Tidskriftsartikel (refereegranskat)abstract
- Pancreatic ductal adenocarcinoma (PDAC) is a major cause of cancer death that typically presents at an advanced stage. No reliable markers for early detection presently exist. The prominent tumor stroma represents a source of circulating biomarkers for use together with cancer cell-derived biomarkers for earlier PDAC diagnosis. CA19-9 and CEA (cancer cell-derived biomarkers), together with endostatin and collagen IV (stroma-derived) were examined alone, or together, by multivariable modelling, using pre-diagnostic plasma samples (n = 259 samples) from the Northern Sweden Health and Disease Study biobank. Serial samples were available for a subgroup of future patients. Marker efficacy for future PDAC case prediction (n = 154 future cases) was examined by both cross-sectional (ROC analysis) and longitudinal analyses. CA19-9 performed well at, and within, six months to diagnosis and multivariable modelling was not superior to CA19-9 alone in cross-sectional analysis. Within six months to diagnosis, CA19-9 (AUC = 0.92) outperformed the multivariable model (AUC = 0.81) at a cross-sectional level. At diagnosis, CA19-9 (AUC = 0.995) and the model (AUC = 0.977) performed similarly. Longitudinal analysis revealed increases in CA19-9 up to two years to diagnosis which indicates a window of opportunity for early detection of PDAC.
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