| 1. |
- Arver, Brita, et al.
(författare)
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Bilateral Prophylactic Mastectomy in Swedish Women at High Risk of Breast Cancer: A National Survey.
- 2011
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Ingår i: Annals of surgery. - : Lippincott Williams and Wilkins; 1999. - 1528-1140 .- 0003-4932. ; 253:6, s. 1147-1154
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND/OBJECTIVE:: This study attempted a national inventory of all bilateral prophylactic mastectomies performed in Sweden between 1995 and 2005 in high-risk women without a previous breast malignancy. The primary aim was to investigate the breast cancer incidence after surgery. Secondary aims were to describe the preoperative risk assessment, operation techniques, complications, histopathological findings, and regional differences. METHODS:: Geneticists, oncologists and surgeons performing prophylactic breast surgery were asked to identify all women eligible for inclusion in their region. The medical records were reviewed in each region and the data were analyzed centrally. The BOADICEA risk assessment model was used to calculate the number of expected/prevented breast cancers during the follow-up period. RESULTS:: A total of 223 women operated on in 8 hospitals were identified. During a mean follow-up of 6.6 years, no primary breast cancer was observed compared with 12 expected cases. However, 1 woman succumbed 9 years post mastectomy to widespread adenocarcinoma of uncertain origin. Median age at operation was 40 years. A total of 58% were BRCA1/2 mutation carriers. All but 3 women underwent breast reconstruction, 208 with implants and 12 with autologous tissue. Four small, unifocal, invasive cancers and 4 ductal carcinoma in situ were found in the mastectomy specimens. The incidence of nonbreast related complications was low (3%). Implant loss due to infection/necrosis occurred in 21 women (10%) but a majority received a new implant later. In total, 64% of the women underwent at least 1unanticipated secondary operation. CONCLUSIONS:: Bilateral prophylactic mastectomy is safe and efficacious in reducing future breast cancer in asymptomatic women at high risk. Unanticipated reoperations are common. Given the small number of patients centralization seems justified.
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| 2. |
- Bjelke, Ulf, et al.
(författare)
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Mollusca : Blötdjur - Molluscs
- 2010
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Ingår i: The 2010 Red List of Swedish Species. Rödlistade arter i Sverige 2010. - Uppsala : ArtDatabanken, SLU. - 9789188506351 ; , s. 495-505
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 3. |
- Buitrago, Elina, et al.
(författare)
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High Throughput Screening of a Catalyst Library for the Asymmetric Transfer Hydrogenation of Heteroaromatic Ketones : Formal Syntheses of (R)-Fluoxetine and (S)-Duloxetine
- 2012
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Ingår i: ChemCatChem. - : Wiley. - 1867-3880 .- 1867-3899. ; 4:12, s. 2082-2089
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Tidskriftsartikel (refereegranskat)abstract
- A total of 21 amino acid based ligands including hydroxy amide, thioamide, and hydroxamic acid functionalities, respectively, were combined with [Ru(p-cymene)Cl2]2 and [RhCp*Cl2]2, and used as catalysts for the asymmetric transfer hydrogenation of four different heteroaromatic ketones in 2-propanol. The reactions were performed on a Chemspeed automated high-throughput screening robotic platform. Optimal catalysts were identified for the individual heterocyclic substrate classes. Based on these results, the formal syntheses of the antidepressant drugs (R)-fluoxetine and (S)-duloxetine were conducted by using the found catalysts in the key reaction step, which results in high isolated yields (94?%) and excellent product enantioselectivities (>99?% ee) of the formed 1,3-amino alcohols.
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| 4. |
- Buitrago, Elina, et al.
(författare)
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Selective reduction of heteroaromatic ketones: A combinatorial approach
- 2011
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The enantioselective reduction of prochiral ketones is a most productiveway towards enantio enriched secondary alcohols used in the preparation of biologically active compounds. There are numerous transition metal catalyzed methods for this transformation, particularly based on Ru(II)-and Rh(I)-complexes, but there is a demand for a larger substrate scope. Heteroaromatic ketones are traditionally more challenging substrates. Normally a catalyst is developed for one benchmark substrate, and asubstrate screen is made with the best performing catalyst. Using this methodology, there is a high probability that for different substrates, another catalyst could outperform the one used. We have executed a multiple screen, containing a variety of different ligands together with both Ru and Rh, and heteroaromatic ketones to fine-tune, and find the optimum catalyst depending on the substrate. The acquired information was used to synthesize known, biologically active compounds, where the key reduction steps were performed with high enantioselectivities and yields.
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| 5. |
- Malmquist, Anna, et al.
(författare)
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Hbtq+ och psykologi i en historisk tillbakablick
- 2017
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Ingår i: HBTQ+ : Psykologiska perspektiv och bemötande - Psykologiska perspektiv och bemötande. - 9789127147430 ; , s. 13-34
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Bokkapitel (refereegranskat)abstract
- De individer, identiteter, uttryck och samlevnadsformer som idag kan sammanfogas under akronymen hbtq+ har genom historien betraktas på många olika vis. Psykologin har varit central för hur hbtq+ har förståtts, definierats och behandlats. I detta kapitel betraktas hbtq+historien därför med psykologiska glasögon.
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| 6. |
- Semb, Gunvor, et al.
(författare)
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A Scandcleft randomised trials of primary surgery for unilateral cleft lip and palate: 1. Planning and management.
- 2017
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Ingår i: Journal of Plastic Surgery and Hand Surgery. - : Taylor & Francis. - 2000-656X .- 2000-6764. ; 51:1, s. 2-13
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND AND AIMS: Longstanding uncertainty surrounds the selection of surgical protocols for the closure of unilateral cleft lip and palate, and randomised trials have only rarely been performed. This paper is an introduction to three randomised trials of primary surgery for children born with complete unilateral cleft lip and palate (UCLP). It presents the protocol developed for the trials in CONSORT format, and describes the management structure that was developed to achieve the long-term engagement and commitment required to complete the project.METHOD: Ten established national or regional cleft centres participated. Lip and soft palate closure at 3-4 months, and hard palate closure at 12 months served as a common method in each trial. Trial 1 compared this with hard palate closure at 36 months. Trial 2 compared it with lip closure at 3-4 months and hard and soft palate closure at 12 months. Trial 3 compared it with lip and hard palate closure at 3-4 months and soft palate closure at 12 months. The primary outcomes were speech and dentofacial development, with a series of perioperative and longer-term secondary outcomes.RESULTS: Recruitment of 448 infants took place over a 9-year period, with 99.8% subsequent retention at 5 years.CONCLUSION: The series of reports that follow this introductory paper include comparisons at age 5 of surgical outcomes, speech outcomes, measures of dentofacial development and appearance, and parental satisfaction. The outcomes recorded and the numbers analysed for each outcome and time point are described in the series.TRIAL REGISTRATION: ISRCTN29932826.
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| 7. |
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| 8. |
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Advancing European entrepreneurship research : entrepreneurship as a working attitude, a mode of thinking and an everyday practice
- 2014. - 1
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Samlingsverk (redaktörskap) (refereegranskat)abstract
- The objective with the Strategic Interest Group in Entrepreneurship (Sig Entrepreneurship) of the European Academy of Management (Euram) is to be the leading research community for engaged entrepreneurship scholars in Europe. The Sig Entrepreneurship aims at promoting research and networking interests for individuals and research groups focused on entrepreneurship and entrepreneurial styles of management. This is done by providing a wide-ranging, engaged and internationally-focused forum to discuss and develop research and practice in the field. We put a distinct focus on the key European feature – 'context matter' – why we try in all activities to promote and stimulate what 'European' might mean in any given context. It means different things in different contexts – and that is the whole point – and thereby the key strength of the European takes on the matter as we see it. This is our idea of the European perspective on entrepreneurship. The tradition of European scholars on entrepreneurship and Smes system has been consolidated during the last three decades and an increasingly distinct European school of thought has emerged as a consequence. This development provides a solid base for the future development of the field where Europe and its entrepreneurship scholars will play an increasingly prominent role. With this concern, this book has been managed, gathering the best contributions of our annual meeting re-edited and improved. The central theme is presenting entrepreneurship understood as a working attitude, a mode of thinking, a concrete everyday practice and increasingly an identity marker for ways of being and living within liquid modernity. Entrepreneurship is nowadays a broadly endorsed and accepted signifier for forms of organizing that targets human, organizational and economic renewal and growth.
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| 9. |
- Balfors, Berit, et al.
(författare)
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Strategisk miljöbedömning för hållbar samhällsplanering : Slutrapport från forskningsprogrammet SPEAK
- 2018
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Strategisk miljöbedömning är en process som myndigheter och kommuner ska genomföra när de upprättar eller ändrar vissa planer eller program som antas medföra betydande miljöpåverkan. Syftet med en miljöbedömning är att integrera miljöaspekter i planen eller programmet så att en hållbar utveckling främjas.Lagstiftningen om strategisk miljöbedömning har funnits i Sverige i snart 15 år. Men hur fungerar miljöbedömning i planeringen? Det var en av frågorna i forskningsprogrammet SPEAK. Syftet med SPEAK har varit att bidra med kunskap för att stärka miljöbedömningens roll som ett verktyg i samhällsplaneringen för att uppnå miljökvalitetsmålen och främja hållbar utveckling.I Sverige har det saknats en övergripande kartläggning över de planer och miljöbedömningar som genomförts. Därför har SPEAK utvecklat, en för Sverige unik, databas med kommunala planer och tillhörande dokument såsom samrådshandlingar, SEA-dokument och särskilda sammanställningar. Baserat på en analys av miljöbedömningspraktiken har förslag på åtgärder tagits fram för att stärka miljöbedömningen som ett verkningsfullt verktyg i planeringen för hållbar utveckling.
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| 10. |
- Berg, Hans E., et al.
(författare)
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Threshold-automated CT measurements of muscle size and radiological attenuation in multiple lower-extremity muscles of older individuals
- 2020
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Ingår i: Clinical Physiology and Functional Imaging. - : WILEY. - 1475-0961 .- 1475-097X. ; 40:3, s. 165-172
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Tidskriftsartikel (refereegranskat)abstract
- Muscle atrophy and fat infiltration, two indicators of deconditioning and weakness in elderly frail patients, are typically assessed by means of manual image analysis from computed tomography (CT) scans. As this time-consuming image analysis limits its wider use in clinical studies, the use of tissue thresholds to semi-automatically assess muscle composition has been suggested. Here, we aimed to investigate the relationship between manual and semi-automated analysis of both cross-sectional area (CSA) and radiological attenuation (RA), in multiple muscles of the lower extremities in aged (77 +/- 6 years) sedentary individuals (n = 40). The participants underwent CT scans of their lower limbs, including hip, thigh and calf muscles. The subsequent analysis of CSA and RA was conducted using both manual segmentation and semi-automatic thresholds (-30 to +150 Hounsfield units). Automated measurements were generally strongly correlated with manually encircled CSA in all muscle groups (R = 0.79-0.99, p < .05) and shortened the analysis time by 70% (p < .05). In m. iliopsoas, however, the CSA became overestimated (15%, p < .05) with thresholded measurements, while the assessment of both CSA and RA was underestimated in muscles with high-fat content (i.e., the gluteal muscles) and in individuals with high-fat infiltration. In conclusion, using the semi-automated technique with conventional thresholds is a time-saving method that delivers accurate gross size of the muscle groups, particularly in the thigh. However, caution should be exercised when using semi-automated techniques for assessing CSA and fat infiltration in muscles with high-fat content.
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