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- Wing, Kajsa, 1977, et al.
(author)
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CD4 T cell activation by myelin oligodendrocyte glycoprotein is suppressed by adult but not cord blood CD25+ T cells.
- 2003
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In: European journal of immunology. - : Wiley. - 0014-2980 .- 1521-4141. ; 33:3, s. 579-87
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Journal article (peer-reviewed)abstract
- Regulatory T cells expressing CD25 have been shown to protect rodents from organ-specific autoimmune diseases. Similar CD25+ cells with a memory phenotype exerting suppressive function after polyclonal or allogeneic stimulation are also present in adult human blood. We demonstrate that adult human CD25+ cells regulate the response to myelin oligodendrocyte glycoprotein (MOG), as depletion of CD25(+) cells increases responses of PBMC and the addition of purified CD25+ cells suppresses MOG-specific proliferation and IFN-gamma production of CD4(+)CD25(-) T cells. In contrast, cord blood CD25+ cells do not inhibit responses to self antigens, and only a small subpopulation of cord CD25+ cells expresses the typical phenotype of adult regulatory T cells (CD45RA(-) and GITR(+)) enabling suppression of polyclonal responses. We conclude that activation of self-reactive T cells in normal healthy individuals is prevented by the presence of self-antigen-specific CD25+ regulatory T cells and that the majority of these cells mature after birth.
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| 3. |
- Ljung, Anna
(author)
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Bortom oskuldens tid : En etnologisk studie av moral, trygghet och otrygghet i skuggan av hiv
- 2001
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Doctoral thesis (other academic/artistic)abstract
- The purpose of this doctoral thesis is to investigate how the Swedish press coverage of AIDS reflects cultural assumptions about morals, security and insecurity and how these representations affect the lives of people who are HIV-positive. It is clear that HIV-positive people are affected by such representations. Images that make some people feel secure have the opposite effect on others. But I have also shown that their lives are not totally constricted by these values. They try to create alternative truths about AIDS. Working from this assumption it has been important to investigate how people try to create meaning and defeat meaninglessness in difficult life circumstances.A further ambition has been to investigate how the body can be viewed as an active part in cultural processes. I argue that it is necessary to adopt a holistic view in cultural conceptualisations of the human body, where physical reactions, emotions and reason are seen as a whole, not ordered hierarchically. My thesis shows that people use different kinds of reasoning in different situations. Knowledge about the actual transmission of the virus, plays a minor part in my informants’ accounts. In some situations a body-based logic dominates, based on fear of transmission through everyday body contact. I argue that trying to suppress or hide bodily signs of the virus is not only a way of avoiding stigmatising behaviour from others, but also a way of achieving control or being able to participate in social situations on the same premises as other people.
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| 5. |
- Sitkauskiene, Brigita, et al.
(author)
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Regulation of Bone Marrow and Airway CD34+ Eosinophils by Interleukin-5
- 2004
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In: Am J Respir Cell Mol Biol. ; 30:3
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Journal article (peer-reviewed)abstract
- The aim of this study was to evaluate the effect of a neutralizing anti-interleukin (IL)-5 monoclonal antibody (TRFK-5) on bone marrow and airway CD34(+) and immature eosinophils. A focus was to determine the effect of the timing of treatment. Balb/c mice were ovalbumin-sensitized and subsequently exposed to ovalbumin for 5-10 d via airway route. Animals were treated intraperitoneally with TRFK-5 or its isotype control (50 microg) once at different time points. Newly produced eosinophils were labeled using 5-bromo-2'-deoxyuridine (BrdU). BrdU(+) and CD34(+) eosinophil numbers were examined by immunocytochemistry. TRFK-5 reduced bone marrow immature eosinophils within 3 d. This effect was closely related to a reduction of BrdU(+) and CD34(+) bone marrow eosinophils, and reduced numbers of blood eosinophils. However, bronchoalveolar lavage (BAL) eosinophilia was not attenuated to the same degree. The effect of TRFK-5 was most prominent in the extended allergen-exposure protocol, where the treatment was given in the middle of the exposure, with strongly reduced bone marrow CD34(+) and immature bone marrow eosinophils, blood eosinophils as well as BAL BrdU(+) eosinophils, and BAL CD34(+) eosinophils. These data argue that anti-IL-5 downregulates eosinophilopoiesis within 3 d by action in the bone marrow, by inhibition of the early stages of eosinophil maturation from CD34(+) cells.
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