SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Lundin Christina 1970 )
 

Sökning: WFRF:(Lundin Christina 1970 ) > (2009) > Type IV collagen is...

Type IV collagen is a tumour stroma-derived biomarker for pancreas cancer

Öhlund, Daniel, 1979- (författare)
Umeå universitet,Kirurgi
Lundin, Christina, 1970- (författare)
Umeå universitet,Kirurgi
Ardnor, Bjarne, 1967- (författare)
Umeå universitet,Kirurgi
visa fler...
Öman, Mikael, 1956- (författare)
Umeå universitet,Kirurgi
Naredi, Peter, 1955- (författare)
Umeå universitet,Kirurgi
Sund, Malin, 1972- (författare)
Umeå universitet,Kirurgi
visa färre...
 (creator_code:org_t)
2009-06-02
2009
Engelska.
Ingår i: British Journal of Cancer. - : Springer Science and Business Media LLC. - 0007-0920 .- 1532-1827. ; 101:1, s. 91-97
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • BACKGROUND: Pancreas cancer is a dreaded disease with high mortality, despite progress in surgical and oncological treatments in recent years. The field is hampered by a lack of good prognostic and predictive tumour biomarkers to be used during follow-up of patients. METHODS: The circulating level of type IV collagen was measured by ELISA in pancreas cancer patients and controls. The expression pattern of type IV collagen in normal pancreas, pancreas cancer tissue and in pancreas cancer cell lines was studied by immunofluorescence and Western blot techniques. RESULTS: Patients with pancreas cancer have significantly increased circulating levels of type IV collagen. In pancreas cancer tissue high levels of type IV collagen expression was found in close proximity to cancer cells in the tumour stroma. Furthermore, pancreas cancer cells were found to produce and secrete type IV collagen in vitro, which in part can explain the high type IV collagen expression observed in pancreas cancer tissue, and the increased circulating levels in pancreas cancer patients. Of clinical importance, our results show that the circulating level of type IV collagen after surgery is strongly related to prognosis in patients treated for pancreas cancer by pancreatico-duodenectomy with curative intent. Persisting high levels of circulating type IV collagen after surgery indicates a quick relapse in disease and poor survival. CONCLUSION: Our results most importantly show that stroma related substances can be evaluated as potential cancer biomarkers, and thereby underline the importance of the tumour microenvironment also in this context.

Nyckelord

extracellular matrix
basement membrane
surgery
circulation
biomarker
pancreas

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

Till lärosätets databas

Sök utanför SwePub

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy