| 1. |
- Lundin, Jonas, et al.
(författare)
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Ängar och hagar i Gävleborg
- 1993
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- En inventering av naturliga fodermarker.Som grund för inventeringen granskades hela länet i IR-flygbilder.Förutom områden som verkade intressanta i flygbildstolkningen kontrollerades även ett stort antal tips från myndigheter, organisationer,naturintresserade privatpersoner och jordbrukare.Inventeringen visade att arealen kvarvarande naturlig fodermark i Gävleborgs län uppgår till 490 ha. Dessa har klassificerats i tre värdeklasser:Hösta värde,Mycket högt värde,Högt värde.I den här rapporten dokumenteras knappt 240 av Gävleborgs återstående ängs- och hagmarker.Här beskrivs också dessa markslags historia,flora och vegetation.Ett kortare avsnitt ägnas åt tips om skötsel och restaurering av dessa våra sista naturliga fodermarker.
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| 2. |
- Lundin, Stefan, et al.
(författare)
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Differences in transport rate of oxytocin and vasopressin analogues across proximal and distal isolated segments of the small intestine of the rat.
- 1991
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Ingår i: Pharmaceutical Research. - 1573-904X. ; 8, s. 1274-1280
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Tidskriftsartikel (refereegranskat)abstract
- The transmural intestinal passage of some oxytocin and vasopressin analogues (oxytocin, OT; [Mpa1, D-Arg8]vasopressin, dDAVP; [Mpa1, Tyr (OMe)2, carba6]oxytocin, carbetocin; [Mpa1, D-Tyr (OEt)2, Thr4, Orn8]vasotocin, antocin II; [Mpa1, D-Tyr (OEt)2, Thr4, desPro7Orn8Gly9NH2]tocinoic acid-NH(CH2)3NH2, desPOG-antocin II-NH(CH2)3NH2) was studied using isolated proximal and distal segments in the rat. All peptides (measured as peptide-like immunoreactivity) displayed a higher transport rate across distal intestinal segments as determined by radioimmunoassay (RIA). The smallest peptide, des POG-antocin II-NH(CH2)3NH2, was transported at the fastest rate. No correlation of lipophilicity with transport rate was observed. Determination of the amount of peptide remaining in the mucosal media at the end of the incubation period by HPLC did not reveal any visible degradation products. However, the large difference in transport rate between [3H]OT and immuno-reactive OT indicates mucosal metabolism of this peptide. [3H]d-DAVP was distributed in a larger mucosal volume than the extracellular space marker [3H]inulin, indicating tissue uptake, but was too low (
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| 3. |
- Lundin, Stefan, et al.
(författare)
-
Pharmacokinetic and pharmacologic properties of antiuterotonic oxytocin analogs in the rat
- 1993
-
Ingår i: Journal of Pharmacology and Experimental Therapeutics. - 1521-0103. ; 264:2, s. 783-788
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Tidskriftsartikel (refereegranskat)abstract
- The pharmacologic and pharmacokinetic properties were evaluated in a series of antiuterotonic oxytocin analogs, modified at positions 1, 2, 4, 8 and, in one case, position 9 of the oxytocin (OT) molecule. [Mpa1,D-Tyr2(Et),Val4,Orn8,desGly9]-OT, [Mpa1,Tyr2(Et),Val4,Orn8]-OT and [Mpa1,D-Tyr2,Val4,Orn8]-OT displayed similar plasma clearance rates (Clps) using the constant infusion method in rats. Two analogs, [Mpa1,D-Tyr2(Et),Val4,Orn8]-OT and, particularly, [Mpa1,D-Tyr2(Et),Thr4,Orn8]-OT, were cleared at significantly higher rates compared with the others. [Mpa1, D-Tyr2(Et), Val4, Orn8]-OT and [Mpa1, D-Tyr2(Et), Thr4, Orn8, desGly9]-OT were most potent in eliciting a short-term in vivo antiuterotonic effect, whereas the duration of effect was longest for [Mpa1, D-Tyr2, Val4, Orn8]-OT and [Mpa1, D-Tyr2(Et), Thr4, Orn8, desGly9]-OT. The Clp of [Mpa1, D-Tyr2, Val4, Orn8]-OT was similar regardless of the infusion rate. No relationship between antiuterotonic effect and Clp of the five peptides could be demonstrated, and no significant linear correlation between Clp and effect duration was found. The apparent volumes of distribution for the present analogs were 10-fold larger than the blood volume, a finding to be considered when measuring in vivo antagonistic activity. The 24-h urinary excretion ranged from 14.3 to 25.6% of the i.v. dose and was negatively correlated with peptide lipophilicity. It is concluded that, in addition to diverging pharmacologic properties, peptide analogs may differ markedly in kinetic parameters like Clp, volumes of distribution and urinary excretion despite minor molecular modifications.
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