| 1. |
- Ahmed, Niaz, et al.
(författare)
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Consensus statements and recommendations from the ESO-Karolinska Stroke Update Conference, Stockholm 11-13 November 2018.
- 2019
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Ingår i: European Stroke Journal. - : SAGE Publications. - 2396-9873 .- 2396-9881. ; 4:4, s. 307-317
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Tidskriftsartikel (refereegranskat)abstract
- The purpose of the European Stroke Organisation-Karolinska Stroke Update Conference is to provide updates on recent stroke therapy research and to give an opportunity for the participants to discuss how these results may be implemented into clinical routine. The meeting started 22 years ago as Karolinska Stroke Update, but since 2014 it is a joint conference with European Stroke Organisation. Importantly, it provides a platform for discussion on the European Stroke Organisation guidelines process and on recommendations to the European Stroke Organisation guidelines committee on specific topics. By this, it adds a direct influence from stroke professionals otherwise not involved in committees and work groups on the guideline procedure. The discussions at the conference may also inspire new guidelines when motivated. The topics raised at the meeting are selected by the scientific programme committee mainly based on recent important scientific publications. This year's European Stroke Organisation-Karolinska Stroke Update Meeting was held in Stockholm on 11-13 November 2018. There were 11 scientific sessions discussed in the meeting including two short sessions. Each session except the short sessions produced a consensus statement (Full version with background, issues, conclusions and references are published as web-material and at www.eso-karolinska.org and http://eso-stroke.org) and recommendations which were prepared by a writing committee consisting of session chair(s), scientific secretary and speakers. These statements were presented to the 250 participants of the meeting. In the open meeting, general participants commented on the consensus statement and recommendations and the final document were adjusted based on the discussion from the general participants Recommendations (grade of evidence) were graded according to the 1998 Karolinska Stroke Update meeting with regard to the strength of evidence. Grade A Evidence: Strong support from randomised controlled trials and statistical reviews (at least one randomised controlled trial plus one statistical review). Grade B Evidence: Support from randomised controlled trials and statistical reviews (one randomised controlled trial or one statistical review). Grade C Evidence: No reasonable support from randomised controlled trials, recommendations based on small randomised and/or non-randomised controlled trials evidence.
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| 2. |
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| 3. |
- Ekblad, Jonas, et al.
(författare)
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Causes of rutting in flexible and semi-rigid test sections after 14 years of service
- 2018
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Ingår i: International Journal on Road Materials and Pavement Design. - : Taylor & Francis. - 1468-0629 .- 2164-7402. ; 19:4, s. 878-897
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Tidskriftsartikel (refereegranskat)abstract
- Rutting is a major distress and is commonly targeted in design-build contracts as a key requirement, but at the same time, contemporary design methods usually provide scarce information on evolution in absolute terms. The objective of this paper is to investigate and analyse rutting results from a large full-scale road test. The analyses concerned magnitudes and the causes of rutting with a main focus on flexible and semi-rigid structures: one Reference, one high-performance asphalt (HPA) and one asphalt on a lean concrete (LC) base. Field measurements and sampling for the current study comprised acquiring transversal profiles and coring pavement samples. The results suggest that for the HPA and the LC base pavements, rutting is mainly caused by studded tyre wear and densification of the asphalt layers. For the conventional reference pavement additional rutting, most likely in the lower layers, was noted.
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| 4. |
- Ekblad, Jonas, et al.
(författare)
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Soft bitumen asphalt produced using RAP
- 2017
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Ingår i: Materials and Structures. - : Springer. - 1359-5997 .- 1871-6873. ; 50:1
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Tidskriftsartikel (refereegranskat)abstract
- Soft bitumen asphalt concrete is a common paving material in Scandinavia. The purpose of this investigation was to indicate the possibility to compensate for the stiff binder of reclaimed asphalt pavement (RAP) by using softer binders compared to the mix design. Characterization of binder mixing and diffusion were carried out using viscosity measurements and tests on asphalt concrete comprised stiffness modulus and cyclic compression testing. Acquired results suggest that virgin and reclaimed binders mix and the viscosity can be predicted using simple mixing models. In the case of asphalt made from mixing virgin and recycled material, the mechanical properties indicates fully mixed binders and mixing occurs during sample manufacturing. In general, this study suggests that soft asphalt mixtures can be produced using RAP and that nominal binder viscosity of the final product can be obtained by compensating the stiff binder of the RAP by virgin bitumen of a softer grade.
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| 5. |
- Ekblad, Jonas, et al.
(författare)
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Texturmätning med vägytemätbil, som indikator för beläggningens friktion
- 2015
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Tillräcklig friktion är en viktig egenskap hos en vägyta. Normal friktionsmätning är omständlig och resurskrävande. Vägytans makrotextur mäts varje år för den större delen av vägnätet. Det skulle därför vara effektivt att använda makrotextur som indikator för nedsatt friktion. I denna rapport studeras sambandet mellan makrotextur och friktion.Mätningar utfördes på ett riktat urval av sträckor i Östergötland. Urvalet riktades mot låga makrotextur-värden. På identifierade sträckor mättes friktion (SAAB Friction Tester) och makrotextur (MPD, Mean Profile Depth med vägytemätbil). Makrotextur mättes av 2 olika mätare.Resultaten tyder på att det inte finns något tillräckligt starkt samband mellan friktion och MPD för att användas som indikator. Några generella mönster kan dock skönjas. Låg friktion uppträder främst vid låg makrotextur dock är det samtidigt endast en mycket liten del av sträckor med låga MPD som uppvisar nedsatt friktion.
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| 6. |
- Garcia, Danilo, 1973, et al.
(författare)
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Twins’ and Their Mothers’ Personality: Temperament and Character Clusters
- 2019
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Ingår i: 3rd Biennial International Convention of Psychological Science, May 25-28, Boston.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- In a sample of twins and their mothers we found, independent of zygosity, two clusters based on differences in the children’s (in)ability to be cooperative and self-directed and her/his level of reward dependence, together with differences in the mother’s levels of cooperativeness, self-directedness, reward dependence, and harm avoidance.
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| 7. |
- Helander, Sara, et al.
(författare)
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Pre-Anchoring of Pin1 to Unphosphorylated c-Myc in a Fuzzy Complex Regulates c-Myc Activity
- 2015
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Ingår i: Structure. - : Cell Press. - 0969-2126 .- 1878-4186. ; 23:12, s. 2267-2279
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Tidskriftsartikel (refereegranskat)abstract
- Hierarchic phosphorylation and concomitant Pin1-mediated proline isomerization of the oncoprotein c-Myc controls its cellular stability and activity. However, the molecular basis for Pin1 recognition and catalysis of c-Myc and other multisite, disordered substrates in cell regulation and disease is unclear. By nuclear magnetic resonance, surface plasmon resonance, and molecular modeling, we show that Pin1 subdomains jointly pre-anchor unphosphorylated c-Myc1–88 in the Pin1 interdomain cleft in a disordered, or “fuzzy”, complex at the herein named Myc Box 0 (MB0) conserved region N-terminal to the highly conserved Myc Box I (MBI). Ser62 phosphorylation in MBI intensifies previously transient MBI-Pin1 interactions in c-Myc1–88 binding, and increasingly engages Pin1PPIase and its catalytic region with maintained MB0 interactions. In cellular assays, MB0 mutated c-Myc shows decreased Pin1 interaction, increased protein half-life, but lowered rates of Myc-driven transcription and cell proliferation. We propose that dynamic Pin1 recognition of MB0 contributes to the regulation of c-Myc activity in cells
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| 8. |
- Hultin Rosenberg, Jonas, 1983-
(författare)
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The All-Affected Principle and its Critics : A Study on Democratic Inclusion
- 2016
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The problem of democratic inclusion, which concerns inclusion in and exclusion from the demos, has attracted significant scholarly attention in the last decade. The all-affected principle seeks to resolve this problem by maintaining that all those and only those who are affected should be included in the demos. But although this principle has often been regarded as a prima facie attractive solution, the literature also claims that it has been “proven” to be unreasonable. The present discussion examines this claim by undertaking a critical evaluation of the arguments upon which it is based – that the all-affected principle is incoherent, that it provides no solution because it presupposes that the problem has already been solved, that it is incompatible with political equality, that it renders a functioning democracy impossible because it either frequently changes the composition of the demos, or generates an overly inclusive demos, and that it challenges established practices of incompetence-based exclusion. Adherents of the all-affected principle must take these arguments seriously since they criticize the principle on its own terms. But insofar as the present study demonstrates that such arguments fail to reveal any generic flaw in the principle, they do not challenge the principle as such, but only certain versions of it. These include the most common version, which requires the inclusion of all those and only those who are both competent and better or worse off as an actual consequence of actual decisions taken by the democratic state. Also affected is the main alternative version, which requires the inclusion of all those and only those who are better or worse off as a possible consequence of a possible decision taken by the democratic state. In response, this thesis proposes a third version of the principle that requires the inclusion of all those and only those who are able to participate, and also better or worse off as a foreseeable consequence of a decision or non-decision that the democratic state has capacity and ability to take. This version avoids the arguments that have been brought against the all-affected principle without compromising that which makes it initially attractive.
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| 9. |
- Lester, Nigel, et al.
(författare)
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The genetic and environmental structure jof the character sub-skales of the temperament and character inventory in adolescence
- 2016
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Ingår i: Annals of General Psychiatry. - : Springer Science and Business Media LLC. - 1744-859X. ; 15:10
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The character higher order scales (self-directedness, cooperativeness, and self-transcendence) in the temperament and character inventory are important general measures of health and well-being [Mens Sana Monograph 11:16-24 (2013)]. Recent research has found suggestive evidence of common environmental influence on the development of these character traits during adolescence. The present article expands earlier research by focusing on the internal consistency and the etiology of traits measured by the lower order sub-scales of the character traits in adolescence. METHODS: The twin modeling analysis of 423 monozygotic pairs and 408 same sex dizygotic pairs estimated additive genetics (A), common environmental (C), and non-shared environmental (E) influences on twin resemblance. All twins were part of the on-going longitudinal Child and Adolescent Twin Study in Sweden (CATSS). RESULTS: The twin modeling analysis suggested a common environmental contribution for two out of five self-directedness sub-scales (0.14 and 0.23), for three out of five cooperativeness sub-scales (0.07-0.17), and for all three self-transcendence sub-scales (0.10-0.12). CONCLUSION: The genetic structure at the level of the character lower order sub-scales in adolescents shows that the proportion of the shared environmental component varies in the trait of self-directedness and in the trait of cooperativeness, while it is relatively stable across the components of self-transcendence. The presence of this unique shared environmental effect in adolescence has implications for understanding the relative importance of interventions and treatment strategies aimed at promoting overall maturation of character, mental health, and well-being during this period of the life span.
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| 10. |
- Lester, Nigel, et al.
(författare)
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The genetic and environmental structure of the character sub-scales of the temperament and character inventory in adolescence.
- 2016
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Ingår i: Annals of General Psychiatry. - : Springer Science and Business Media LLC. - 1744-859X. ; 15
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The character higher order scales (self-directedness, cooperativeness, and self-transcendence) in the temperament and character inventory are important general measures of health and well-being [Mens Sana Monograph 11:16-24 (2013)]. Recent research has found suggestive evidence of common environmental influence on the development of these character traits during adolescence. The present article expands earlier research by focusing on the internal consistency and the etiology of traits measured by the lower order sub-scales of the character traits in adolescence.METHODS: The twin modeling analysis of 423 monozygotic pairs and 408 same sex dizygotic pairs estimated additive genetics (A), common environmental (C), and non-shared environmental (E) influences on twin resemblance. All twins were part of the on-going longitudinal Child and Adolescent Twin Study in Sweden (CATSS).RESULTS: The twin modeling analysis suggested a common environmental contribution for two out of five self-directedness sub-scales (0.14 and 0.23), for three out of five cooperativeness sub-scales (0.07-0.17), and for all three self-transcendence sub-scales (0.10-0.12).CONCLUSION: The genetic structure at the level of the character lower order sub-scales in adolescents shows that the proportion of the shared environmental component varies in the trait of self-directedness and in the trait of cooperativeness, while it is relatively stable across the components of self-transcendence. The presence of this unique shared environmental effect in adolescence has implications for understanding the relative importance of interventions and treatment strategies aimed at promoting overall maturation of character, mental health, and well-being during this period of the life span.
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