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Detection of IgE Re...
Detection of IgE Reactivity to a Handful of Allergen Molecules in Early Childhood Predicts Respiratory Allergy in Adolescence
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- Wickman, Magnus (författare)
- Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Inst Environm Med, Stockholm, Sweden; Stockholm Cty Council, Ctr Occupat & Environm Med, Stockholm, Sweden
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- Lupinek, Christian (författare)
- Med Univ Vienna, Ctr Pathophysiol Infectiol & Immunol, Dept Pathophysiol & Allergy Res, Div Immunopathol, Vienna, Austria
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- Andersson, Niklas (författare)
- Karolinska Institutet
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- Belgrave, Danielle (författare)
- Imperial Coll, Dept Paediat, London, England
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- Asarnoj, Anna (författare)
- Karolinska Institutet
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- Benet, Marta (författare)
- Ctr Res Environm Epidemiol CREAL, ISGlobal, Barcelona, Spain
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- Pinart, Mariona (författare)
- Ctr Res Environm Epidemiol CREAL, ISGlobal, Barcelona, Spain
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- Wieser, Sandra (författare)
- Med Univ Vienna, Ctr Pathophysiol Infectiol & Immunol, Dept Pathophysiol & Allergy Res, Div Immunopathol, Vienna, Austria
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- Garcia-Aymerich, Judith (författare)
- Ctr Res Environm Epidemiol CREAL, ISGlobal, Barcelona, Spain
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- Baar, Alexandra (författare)
- Med Univ Vienna, Ctr Pathophysiol Infectiol & Immunol, Dept Pathophysiol & Allergy Res, Div Immunopathol, Vienna, Austria
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- Pershagen, Göran (författare)
- Karolinska Institutet
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- Simpson, Angela (författare)
- Univ Manchester, Div Infect Immun & Resp Med, Fac Biol Med & Hlth, Manchester, Lancs, England
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- Kull, Inger (författare)
- Karolinska Institutet
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- Bergström, Anna (författare)
- Karolinska Inst, Inst Environm Med, Stockholm, Sweden; Stockholm Cty Council, Ctr Occupat & Environm Med, Stockholm, Sweden
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- Melén, Erik (författare)
- Karolinska Institutet
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- Hamsten, Carl (författare)
- Karolinska Institutet
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- Antó, Josep M. (författare)
- Ctr Res Environm Epidemiol CREAL, ISGlobal, Barcelona, Spain; UPF, Hosp del Mar, Med Res Inst, IMIM, Barcelona, Spain; CIBERESP, Barcelona, Spain; UPF, Barcelona, Spain
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- Bousquet, Jean (författare)
- Univ Hosp, Montpellier, France; INSERM, VIMA Ageing & Chron Dis, Paris, France; U1168, Epidemiol & Publ Hlth Approaches, Paris, France; Univ Versailles St Quentin En Yvelines, UVSQ, Versailles, France
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- Custovic, Adnan (författare)
- Imperial Coll, Dept Paediat, London, England
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- Valenta, Rudolf (författare)
- Med Univ Vienna, Ctr Pathophysiol Infectiol & Immunol, Dept Pathophysiol & Allergy Res, Div Immunopathol, Vienna, Austria
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- van Hage, Marianne (författare)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier BV, 2017
- 2017
- Engelska.
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Ingår i: EBioMedicine. - : Elsevier BV. - 2352-3964. ; 26, s. 91-99
- Relaterad länk:
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https://doi.org/10.1...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Sensitization in early childhood may precede respiratory allergy in adolescence.Methods: IgE reactivity against 132 allergen molecules was evaluated using the MeDALL microarray in sera obtained from a random sample of 786 children at the age of 4, 8 and 16 years in a population based birth cohort (BAMSE). Symptoms were analyzed by questionnaire at ages 4, 8 and 16 years. Clinically and independent relevant allergen molecules accounting for ≥ 90% of IgE reactivities in sensitized individuals and at all time-points were identified as risk molecules and used to predict respiratory allergy. The data was replicated in the Manchester Asthma and Allergy Study (MAAS) birth cohort by studying IgE reactivity with the use of a commercial IgE microarray. Sera were obtained from children at the ages of 3, 5, 8 and 11 years (N = 248) and the outcome was studied at 11 years.Findings: In the BAMSE cohort 4 risk molecules could be identified, i.e.: Ara h 1 (peanut), Bet v 1 (birch), Fel d 1 (cat), Phl p 1 (grass). For MAAS the corresponding number of molecules was 5: Der p 1 (dust mite), Der f 2 (dust mite), Phl p 1 (grass), Phl p 5 (grass), Fel d 1 (cat). In BAMSE, early IgE reactivity to ≥ 3 of 4 allergen molecules at four years predicted incident and persistent asthma and/or rhinitis at 16 years (87% and 95%, respectively). The corresponding proportions in the MAAS cohort at 16 years were 100% and 100%, respectively, for IgE reactivity to ≥ 3 of 5 risk molecules.Interpretations: IgE reactivity to a few allergen molecules early in life identifies children with a high risk of asthma and/or rhinitis at 16 years. These findings will be of importance for developing preventive strategies for asthma and rhinitis in children.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- Asthma
- IgE
- Prediction
- Rhinitis
- Sensitisation
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Wickman, Magnus
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Lupinek, Christi ...
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Andersson, Nikla ...
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Belgrave, Daniel ...
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Asarnoj, Anna
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Benet, Marta
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visa fler...
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Pinart, Mariona
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Wieser, Sandra
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Garcia-Aymerich, ...
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Baar, Alexandra
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Pershagen, Göran
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Simpson, Angela
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Kull, Inger
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Bergström, Anna
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Melén, Erik
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Hamsten, Carl
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Antó, Josep M.
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Bousquet, Jean
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Custovic, Adnan
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Valenta, Rudolf
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van Hage, Marian ...
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