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Engineering Genetic...
Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis
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- Huang, Miller (författare)
- Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94158 USA;Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94158 USA
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- Tailor, Jignesh (författare)
- Univ Cambridge, MRC Stem Cell Inst, Wellcome Trust, Tennis Court Rd, Cambridge CB2 1QR, England;Inst Canc Res, London SM2 5NG, England;Hosp Sick Children, Dev & Stem Cell Biol Program, Toronto, ON, Canada;Hosp Sick Children, Div Neurosurg, Toronto, ON, Canada
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- Zhen, Qiqi (författare)
- Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94158 USA;Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94158 USA
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visa fler...
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- Gillmor, Aaron H. (författare)
- Univ Calgary, Dept Biochem & Mol Biol, Calgary, AB, Canada;Univ Calgary, Charbonneau Canc Inst, Calgary, AB, Canada;Alberta Childrens Prov Gen Hosp, Res Inst, Calgary, AB, Canada
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- Miller, Matthew L. (författare)
- Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94158 USA;Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94158 USA
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- Weishaupt, Holger (författare)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab
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- Chen, Justin (författare)
- Stanford Univ, Dept Genet, Sch Med, Stanford, CA 94305 USA
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- Zheng, Tina (författare)
- Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94158 USA;Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94158 USA
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- Nash, Emily K. (författare)
- Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94158 USA;Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94158 USA
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- McHenry, Lauren K. (författare)
- Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94158 USA;Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94158 USA
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- An, Zhenyi (författare)
- Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94158 USA;Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94158 USA
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- Ye, Fubaiyang (författare)
- Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94158 USA;Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94158 USA
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- Takashima, Yasuhiro (författare)
- Univ Cambridge, MRC Stem Cell Inst, Wellcome Trust, Tennis Court Rd, Cambridge CB2 1QR, England
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- Clarke, James (författare)
- Univ Cambridge, MRC Stem Cell Inst, Wellcome Trust, Tennis Court Rd, Cambridge CB2 1QR, England
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- Ayetey, Harold (författare)
- Univ Cambridge, MRC Stem Cell Inst, Wellcome Trust, Tennis Court Rd, Cambridge CB2 1QR, England
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- Cavalli, Florence Mg (författare)
- Hosp Sick Children, Dev & Stem Cell Biol Program, Toronto, ON, Canada;Hosp Sick Children, Arthur & Sonia Labatt Brain Tumour Res Ctr, Toronto, ON, Canada
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- Luu, Betty (författare)
- Hosp Sick Children, Dev & Stem Cell Biol Program, Toronto, ON, Canada;Hosp Sick Children, Arthur & Sonia Labatt Brain Tumour Res Ctr, Toronto, ON, Canada
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- Moriarity, Branden S. (författare)
- Univ Minnesota, Dept Pediat, Minneapolis, MN 55455 USA;Univ Minnesota, Ctr Genome Engn, Minneapolis, MN 55455 USA;Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN 55455 USA
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- Ilkhanizadeh, Shirin (författare)
- Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94158 USA;Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94158 USA
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- Chavez, Lukas (författare)
- Hopp Childrens Canc Ctr KiTZ, Heidelberg, Germany;German Canc Consortium DKTK, Div Pediat Neurooncol, German Canc Res Ctr DKFZ, Heidelberg, Germany
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- Yu, Chunying (författare)
- Hosp Sick Children, Dev & Stem Cell Biol Program, Toronto, ON, Canada
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- Kurian, Kathreena M. (författare)
- Univ Bristol, Southmead Hosp, Inst Clin Neurosci, Level 1,Learning & Res Bldg, Bristol BS10 5NB, Avon, England
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- Magnaldo, Thierry (författare)
- Nice UMR CNRS 7284 INSERM U1081 UNS UCA, Inst Res Canc & Aging, Nice, France
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- Sevenet, Nicolas (författare)
- Univ Bordeaux, Inst Bergonie, 229 Cours Argonne, F-33076 Bordeaux, France;Univ Bordeaux, INSERM U1218, 229 Cours Argonne, F-33076 Bordeaux, France
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- Koch, Philipp (författare)
- Heidelberg Univ, Cent Inst Mental Hlth, Med Fac Mannheim, Mannheim, Germany;Hector Inst Translat Brain Res HITBR gGmbH, Mannheim, Germany;German Canc Res Ctr, Heidelberg, Germany
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- Pollard, Steven M. (författare)
- Univ Edinburgh, MRC Ctr Regenerat Med, Edinburgh, Midlothian, Scotland;Univ Edinburgh, Canc Res UK Edinburgh Ctr, Edinburgh, Midlothian, Scotland
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- Dirks, Peter (författare)
- Hosp Sick Children, Dev & Stem Cell Biol Program, Toronto, ON, Canada;Hosp Sick Children, Div Neurosurg, Toronto, ON, Canada;Hosp Sick Children, Arthur & Sonia Labatt Brain Tumour Res Ctr, Toronto, ON, Canada
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- Snyder, Michael P. (författare)
- Stanford Univ, Dept Genet, Sch Med, Stanford, CA 94305 USA
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- Largaespada, David A. (författare)
- Univ Minnesota, Dept Pediat, Minneapolis, MN 55455 USA;Univ Minnesota, Ctr Genome Engn, Minneapolis, MN 55455 USA;Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN 55455 USA
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- Cho, Yoon Jae (författare)
- Oregon Hlth & Sci Univ, Dept Pediat, Div Pediat Neurol, 3181 Sw Sam Jackson Pk Rd, Portland, OR 97201 USA;Oregon Hlth & Sci Univ, Dept Pediat, Pape Family Pediat Res Inst, 3181 Sw Sam Jackson Pk Rd, Portland, OR 97201 USA;Oregon Hlth & Sci Univ, Knight Canc Inst, Portland, OR 97201 USA
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- Phillips, Joanna J. (författare)
- Univ Calif San Francisco, Dept Neurol Surg, San Francisco, CA 94158 USA;Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94158 USA
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- Johansson Swartling, Fredrik, 1975- (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Neuroonkologi
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- Morrissy, A. Sorana (författare)
- Hosp Sick Children, Dev & Stem Cell Biol Program, Toronto, ON, Canada;Univ Calgary, Dept Biochem & Mol Biol, Calgary, AB, Canada;Univ Calgary, Charbonneau Canc Inst, Calgary, AB, Canada;Alberta Childrens Prov Gen Hosp, Res Inst, Calgary, AB, Canada;Hosp Sick Children, Arthur & Sonia Labatt Brain Tumour Res Ctr, Toronto, ON, Canada
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- Kool, Marcel (författare)
- Hopp Childrens Canc Ctr KiTZ, Heidelberg, Germany;German Canc Consortium DKTK, Div Pediat Neurooncol, German Canc Res Ctr DKFZ, Heidelberg, Germany
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- Pfister, Stefan M. (författare)
- Hopp Childrens Canc Ctr KiTZ, Heidelberg, Germany;German Canc Consortium DKTK, Div Pediat Neurooncol, German Canc Res Ctr DKFZ, Heidelberg, Germany;Heidelberg Univ Hosp, Dept Pediat Hematol & Oncol, Heidelberg, Germany
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- Taylor, Michael D. (författare)
- Hosp Sick Children, Dev & Stem Cell Biol Program, Toronto, ON, Canada;Hosp Sick Children, Div Neurosurg, Toronto, ON, Canada;Hosp Sick Children, Arthur & Sonia Labatt Brain Tumour Res Ctr, Toronto, ON, Canada;Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada
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- Smith, Austin (författare)
- Univ Cambridge, MRC Stem Cell Inst, Wellcome Trust, Tennis Court Rd, Cambridge CB2 1QR, England
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- Weiss, William A. (författare)
- Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94158 USA;Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94158 USA;Univ Calif San Francisco, Res Ctr, Dept Pediat, San Francisco, CA 94158 USA;Univ Calif San Francisco, Res Ctr, Dept Neurosurg, San Francisco, CA 94158 USA;Univ Calif San Francisco, Res Ctr, Dept Brain Tumor, San Francisco, CA 94158 USA
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(creator_code:org_t)
- CELL PRESS, 2019
- 2019
- Engelska.
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Ingår i: Cell Stem Cell. - : CELL PRESS. - 1934-5909 .- 1875-9777. ; 25:3, s. 433-
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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http://www.cell.com/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Human neural stem cell cultures provide progenitor cells that are potential cells of origin for brain cancers. However, the extent to which genetic predisposition to tumor formation can be faithfully captured in stem cell lines is uncertain. Here, we evaluated neuroepithelial stem (NES) cells, representative of cerebellar progenitors. We transduced NES cells with MYCN, observing medulloblastoma upon orthotopic implantation in mice. Significantly, transcriptomes and patterns of DNA methylation from xenograft tumors were globally more representative of human medulloblastoma compared to a MYCN-driven genetically engineered mouse model. Orthotopic transplantation of NES cells generated from Gorlin syndrome patients, who are predis- posed to medulloblastoma due to germline-mutated PTCH1, also generated medulloblastoma. We engineered candidate cooperating mutations in Gorlin NES cells, with mutation of DDX3X or loss of GSE1 both accelerating tumorigenesis. These findings demonstrate that human NES cells provide a potent experimental resource for dissecting genetic causation in medulloblastoma.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
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- Av författaren/redakt...
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Huang, Miller
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Tailor, Jignesh
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Zhen, Qiqi
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Gillmor, Aaron H ...
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Miller, Matthew ...
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Weishaupt, Holge ...
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visa fler...
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Chen, Justin
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Zheng, Tina
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Nash, Emily K.
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McHenry, Lauren ...
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An, Zhenyi
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Ye, Fubaiyang
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Takashima, Yasuh ...
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Clarke, James
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Ayetey, Harold
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Cavalli, Florenc ...
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Luu, Betty
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Moriarity, Brand ...
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Ilkhanizadeh, Sh ...
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Chavez, Lukas
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Yu, Chunying
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Kurian, Kathreen ...
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Magnaldo, Thierr ...
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Sevenet, Nicolas
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Koch, Philipp
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Pollard, Steven ...
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Dirks, Peter
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Snyder, Michael ...
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Largaespada, Dav ...
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Cho, Yoon Jae
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Phillips, Joanna ...
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Johansson Swartl ...
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Morrissy, A. Sor ...
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Kool, Marcel
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Pfister, Stefan ...
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Taylor, Michael ...
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Smith, Austin
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Weiss, William A ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Cell och molekyl ...
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Cellbiologi
- Artiklar i publikationen
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Cell Stem Cell
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Uppsala universitet