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Träfflista för sökning "WFRF:(Lv Gang) srt2:(2010-2014)"

Search: WFRF:(Lv Gang) > (2010-2014)

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1.
  • Deng, Min, et al. (author)
  • Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis
  • 2013
  • In: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 45:6, s. 697-
  • Journal article (peer-reviewed)abstract
    • To identify susceptibility genes for amyotrophic lateral sclerosis (ALS), we conducted a genome-wide association study (GWAS) in 506 individuals with sporadic ALS and 1,859 controls of Han Chinese ancestry. Ninety top SNPs suggested by the current GWAS and 6 SNPs identified by previous GWAS were analyzed in an independent cohort of 706 individuals with ALS and 1,777 controls of Han Chinese ancestry. We discovered two new susceptibility loci for ALS at 1q32 (CAMK1G, rs6703183, P-combined = 2.92 x 10(-8), odds ratio (OR) = 1.31) and 22p11 (CABIN1 and SUSD2, rs8141797, P-combined = 2.35 x 10(-9), OR = 1.52). These two loci explain 12.48% of the overall variance in disease risk in the Han Chinese population. We found no association evidence for the previously reported loci in the Han Chinese population, suggesting genetic heterogeneity of disease susceptibility for ALS between ancestry groups. Our study identifies two new susceptibility loci and suggests new pathogenic mechanisms of ALS.
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2.
  • Zhang, Renyun, et al. (author)
  • Real time monitoring of the drug release of rhodamine B on graphene oxide
  • 2011
  • In: Carbon. - : Elsevier BV. - 0008-6223 .- 1873-3891. ; 49:4, s. 1126-1132
  • Journal article (peer-reviewed)abstract
    • A real time method for monitoring the drug load and release on graphene oxide (GO) in a cuvette is reported using rhodamine B (RB) as a model for a drug. The mechanisms of the release of RB at different pH were investigated, by monitoring the time dependency of the accumulative drug release. In vitro real time experimental results indicated that RB could be loaded on GO with a capacity of 0.5 mg/mg. The drug release of RB was pH sensitive as observed at pH 7.4 and pH 4.5 PBS solutions. The higher pH values lead to weaker hydrophobic force and hydrogen bonds, and thus higher release rate. The ionic strength also influenced the release of RB, as shown from the different release rates between PBS solutions and double distilled water. These results indicated a case II transport process at pH 7.4 and an anomalous diffusion process at pH 4.5 and in water. The method described here allows real time detection of the drug release rate, in contrast to common dialysis analysis. This method also points to other real time detections in biomedical investigations.
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