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Sökning: WFRF:(Ly Amy) > (2024)

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1.
  • Elfer, Katherine, et al. (författare)
  • Reproducible Reporting of the Collection and Evaluation of Annotations for Artificial Intelligence Models
  • 2024
  • Ingår i: Modern Pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. - 1530-0285. ; 37:4
  • Tidskriftsartikel (refereegranskat)abstract
    • This work advances and demonstrates the utility of a reporting framework for collecting and evaluating annotations of medical images used for training and testing artificial intelligence (AI) models in assisting detection and diagnosis. AI has unique reporting requirements, as shown by the AI extensions to the CONSORT (Consolidated Standards of Reporting Trials) and SPIRIT (Standard Protocol Items: Recommendations for Interventional Trials) checklists and the proposed AI extensions to the STARD (Standards for Reporting Diagnostic Accuracy) and TRIPOD (Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis) checklists. AI for detection and/or diagnostic image analysis requires complete, reproducible, and transparent reporting of the annotations and metadata used in training and testing datasets. Prior work by Wahab et al. proposed an annotation workflow and quality checklist for computational pathology annotations. In this manuscript, we operationalize this workflow into an evaluable quality checklist that applies to any reader-interpreted medical images, and we demonstrate its use for an annotation effort in digital pathology. We refer to this quality framework as CLEARR-AI: The Collection and Evaluation of Annotations for Reproducible Reporting of Artificial Intelligence.
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2.
  • Ly, Amy, et al. (författare)
  • Training pathologists to assess stromal tumour-infiltrating lymphocytes in breast cancer synergises efforts in clinical care and scientific research
  • 2024
  • Ingår i: Histopathology. - 0309-0167 .- 1365-2559. ; 84:6, s. 915-923
  • Forskningsöversikt (refereegranskat)abstract
    • A growing body of research supports stromal tumour-infiltrating lymphocyte (TIL) density in breast cancer to be a robust prognostic and predicive biomarker. The gold standard for stromal TIL density quantitation in breast cancer is pathologist visual assessment using haematoxylin and eosin-stained slides. Artificial intelligence/machine-learning algorithms are in development to automate the stromal TIL scoring process, and must be validated against a reference standard such as pathologist visual assessment. Visual TIL assessment may suffer from significant interobserver variability. To improve interobserver agreement, regulatory science experts at the US Food and Drug Administration partnered with academic pathologists internationally to create a freely available online continuing medical education (CME) course to train pathologists in assessing breast cancer stromal TILs using an interactive format with expert commentary. Here we describe and provide a user guide to this CME course, whose content was designed to improve pathologist accuracy in scoring breast cancer TILs. We also suggest subsequent steps to translate knowledge into clinical practice with proficiency testing.
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