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Sökning: WFRF:(Lynham Steven) > (2017) > Differences in the ...

Differences in the coronal proteome acquired by particles depositing in the lungs of asthmatic versus healthy humans

Kumar, Abhinav (författare)
Institute of Pharmaceutical Science, Faculty of Life Sciences and Medicine, King's College, London, UK
Bicer, Elif Melis (författare)
MRC-PHE Centre for Environment and Health, Analytical & Environmental Sciences Division, Faculty of Life Sciences and Medicine, King's College, London, UK
Pfeffer, Paul (författare)
MRC-PHE Centre for Environment and Health, Analytical & Environmental Sciences Division, Faculty of Life Sciences and Medicine, King's College, London, UK,Pharmaceutical and Medical Chemistry, Royal College of Surgeons in Ireland, Dublin 2, Ireland.; Centre for BioNano Interactions, University College Dublin, Dublin 4, Ireland
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Monopoli, Marco P (författare)
Pharmaceutical and Medical Chemistry, Royal College of Surgeons in Ireland, Dublin 2, Ireland.; Centre for BioNano Interactions, University College Dublin, Dublin 4, Ireland
Dawson, Kenneth A (författare)
Centre for BioNano Interactions, University College Dublin, Dublin 4, Ireland
Eriksson, Jonny (författare)
Uppsala universitet,Analytisk kemi,Edwards grupp
Edwards, Katarina (författare)
Uppsala universitet,Analytisk kemi,Edwards grupp
Lynham, Steven (författare)
Institute of Psychiatry, Psychology and Neuroscience, Faculty of Life Sciences and Medicine, King's College, London, UK
Arno, Matthew (författare)
Genomics Centre, Faculty of Life Sciences and Medicine, King's College, London
Behndig, Annelie F. (författare)
Umeå universitet,Lungmedicin,Department of Public Health and Clinical Medicine, Division of Medicine/Respiratory Medicine, Umeå University, Umeå, Sweden
Blomberg, Anders (författare)
Umeå universitet,Lungmedicin,Department of Public Health and Clinical Medicine, Division of Medicine/Respiratory Medicine, Umeå University, Umeå, Sweden
Somers, Graham (författare)
GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, UK
Hassall, Dave (författare)
GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, UK
Dailey, Lea Ann (författare)
Institute of Pharmaceutical Science, Faculty of Life Sciences and Medicine, King's College, London, UK
Forbes, Ben (författare)
Institute of Pharmaceutical Science, Faculty of Life Sciences and Medicine, King's College, London, UK
Mudway, Ian (författare)
MRC-PHE Centre for Environment and Health, Analytical & Environmental Sciences Division, Faculty of Life Sciences and Medicine, King's College, London, UK
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 (creator_code:org_t)
Elsevier BV, 2017
2017
Engelska.
Ingår i: Nanomedicine. - : Elsevier BV. - 1549-9634 .- 1549-9642. ; 13:8, s. 2517-2521
Relaterad länk:
https://kclpure.kcl....
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https://urn.kb.se/re...
https://doi.org/10.1...
https://urn.kb.se/re...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Most inhaled nanomedicines in development are for the treatment of lung disease, yet little is known about their interaction with the respiratory tract lining fluids (RTLFs). Here we combined the use of nano-silica, as a protein concentrator, with label-free snapshot proteomics (LC-MS/MS; key findings confirmed by ELISA) to generate a quantitative profile of the RTLF proteome and provided insight into the evolved corona; information that may be used in future to improve drug targeting to the lungs by inhaled medicines. The asthmatic coronal proteome displayed a reduced contribution of surfactant proteins (SP-A and B) and a higher contribution of α1-antitrypsin. Pathway analysis suggested that asthmatic RTLFs may also be deficient in proteins related to metal handling (e.g. lactoferrin). This study demonstrates how the composition of the corona acquired by inhaled nanoparticles is modified in asthma and suggests depressed mucosal immunity even in mild airway disease.

Ämnesord

NATURVETENSKAP  -- Kemi -- Fysikalisk kemi (hsv//swe)
NATURAL SCIENCES  -- Chemical Sciences -- Physical Chemistry (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
TEKNIK OCH TEKNOLOGIER  -- Nanoteknik (hsv//swe)
ENGINEERING AND TECHNOLOGY  -- Nano-technology (hsv//eng)

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