| 1. |
- Bloomfield, Kim, et al.
(author)
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Changes in Alcohol-Related Problems After Alcohol Policy Changes in Denmark, Finland, and Sweden
- 2010
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In: Journal of Studies on Alcohol and Drugs. - New Jersey : Rutgers, the State University of New Jersey. - 1937-1888. ; 71:1, s. 32-40
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Journal article (peer-reviewed)abstract
- Objective: European Union travelers' allowances for alcohol import to Denmark, Sweden, and Finland were abolished in 2004. In addition, excise taxes on alcohol were lowered in 2003 and 2005 in Denmark, and in 2004 in Finland. Using northern Sweden as a control site, this study examines whether levels of reported alcohol problems have changed in Denmark, Finland, and southern Sweden as a consequence of these policy changes. Method: Annual cross-sectional surveys were conducted in Denmark, Finland, and Sweden from 2003 to 2006. Five dependency items and seven extrinsic alcohol-related problems were examined. Changes were analyzed within each country/region with logistic regressions and tested for short- and long-term changes. Differential change was also tested between each country and the control site, northern Sweden. Results: Prevalence of alcohol problems decreased over the study period. Only in selected subgroups did problems increase. This mainly occurred in the samples for northern Sweden and Finland, and mostly among older age groups and men. In relation to the control site, however, no increases in problem prevalence were found. Conclusions: Our findings on a decline in reported alcohol problems largely agree with published reports on alcohol consumption over the same period in the study countries. They do not agree, however, with findings on changes in health and social statistics in Finland and Denmark, where some significant increases in alcohol-related harm have been found.
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| 2. |
- Härkönen, Janne, et al.
(author)
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Changes in Finnish drinking occasions between 1976 and 2008 – The waxing and waning of drinking contexts
- 2013
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In: Addiction Research and Theory. - : Informa UK Limited. - 1606-6359 .- 1476-7392. ; 21:4, s. 318-328
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Journal article (peer-reviewed)abstract
- A deeper understanding of drinking practices of a population requires a study of the situations in which people drink, i.e. the context of drinking. This study explores the changes and continuities in the prevalence and nature of drinking in terms of place, company, time and the social drinking context, during a period when overall alcohol consumption in Finland grew by half and drinking culture at large was transformed radically. Analyses were based on two national drinking habits surveys with a representative sample of the Finnish population aged 15–69 years in 1976 (N = 2835) and 2008 (N = 2725). In addition, original semi-qualitative data in 2008 were utilized, using a 15-category social drinking context typology, with the results contrasted to previously reported results from 1976. Overall, the number of drinking occasions increased between 1976 and 2008. A major part of the increase comprised drinking in home settings and with one's partner. The weekly rhythm of drinking was also concentrated on weekends even more than before. Changes in the nature of drinking showed that the typical degree of intoxication decreased for men and increased for women. The proportion of heavy drinking occasions decreased for men especially in home settings and for women, remained the same across drinking contexts except for single gender contexts. Changes in social drinking contexts reflected an overall shifting of drinking into the private sphere, with a major increase in the proportion of evenings at home and sauna drinking.
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| 3. |
- Strauss, Leena, et al.
(author)
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Seminal vesicles and urinary bladder as sites of aromatization of androgens in men, evidenced by a CYP19A1-driven luciferase reporter mouse and human tissue specimens.
- 2013
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In: The FASEB Journal. - : Wiley. - 0892-6638 .- 1530-6860. ; 27:4, s. 1342-50
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Journal article (peer-reviewed)abstract
- The human CYP19A1 gene is expressed in various tissues by the use of tissue-specific promoters, whereas the rodent cyp19a1 gene is expressed mainly in the gonads and brain. We generated a transgenic mouse model containing a >100-kb 5' region of human CYP19A1 gene connected to a luciferase reporter gene. The luciferase activity in mouse tissues mimicked the CYP19A1 gene expression pattern in humans. Interestingly, the reporter gene activity was 16 and 160 times higher in the urinary bladder and seminal vesicles, respectively, as compared with the activity in the testis. Accordingly, CYP19A1 gene and P450arom protein expression was detected in those human tissues. Moreover, the data revealed that the expression of CYP19A1 gene is driven by promoters PII, I.4, and I.3 in the seminal vesicles, and by promoters PII and I.4 in the urinary bladder. Furthermore, the reporter gene expression in the seminal vesicles was androgen dependent: Castration decreased the expression ∼20 times, and testosterone treatment restored it to the level of an intact mouse. This reporter mouse model facilitates studies of tissue-specific regulation of the human CYP19A1 gene, and our data provide evidence for seminal vesicles as important sites for estrogen production in males.-Strauss, L., Rantakari, P., Sjögren, K., Salminen, A., Lauren, E., Kallio, J., Damdimopoulou, P., Boström, M., Boström, P. J., Pakarinen, P., Zhang, F. P., Kujala, P., Ohlsson, C., Mäkelä, S., Poutanen, M. Seminal vesicles and urinary bladder as sites of aromatization of androgens in men, evidenced by a CYP19A1-driven luciferase reporter mouse and human tissue specimens.
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