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| 2. |
- Brinkmalm, Gunnar, et al.
(författare)
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An online nano-LC-ESI-FTICR-MS method for comprehensive characterization of endogenous fragments from amyloid β and amyloid precursor protein in human and cat cerebrospinal fluid.
- 2012
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Ingår i: Journal of mass spectrometry : JMS. - : Wiley. - 1096-9888 .- 1076-5174. ; 47:5, s. 591-603
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Tidskriftsartikel (refereegranskat)abstract
- Amyloid precursor protein (APP) is the precursor protein to amyloid β (Aβ), the main constituent of senile plaques in Alzheimer's disease (AD). Endogenous Aβ peptides reflect the APP processing, and greater knowledge of different APP degradation pathways is important to understand the mechanism underlying AD pathology. When one analyzes longer Aβ peptides by low-energy collision-induced dissociation tandem mass spectrometry (MS/MS), mainly long b-fragments are observed, limiting the possibility to determine variations such as amino acid variants or post-translational modifications (PTMs) within the N-terminal half of the peptide. However, by using electron capture dissociation (ECD), we obtained a more comprehensive sequence coverage for several APP/Aβ peptide species, thus enabling a deeper characterization of possible variants and PTMs. Abnormal APP/Aβ processing has also been described in the lysosomal storage disease Niemann-Pick type C and the major large animal used for studying this disease is cat. By ECD MS/MS, a substitution of Asp7 → Glu in cat Aβ was identified. Further, sialylated core 1 like O-glycans at Tyr10, recently discovered in human Aβ (a previously unknown glycosylation type), were identified also in cat cerebrospinal fluid (CSF). It is therefore likely that this unusual type of glycosylation is common for (at least) species belonging to the magnorder Boreoeutheria. We here describe a detailed characterization of endogenous APP/Aβ peptide species in CSF by using an online top-down MS-based method.
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| 3. |
- Månsson, Annika
(författare)
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Becoming a preschool child : Subjectification in toddlers during their introduction to preschool, from a gender perspective
- 2011
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Ingår i: International Journal of Early Childhood. - : Springer Science Press. - 0020-7187 .- 1878-4658. ; 43:1, s. 7-22
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Tidskriftsartikel (refereegranskat)abstract
- Abstract The aim of this paper is to contribute to the knowledge of children’s introduction to pre-school as social practice with a focus on subjectification from a gender perspective. This introductory process is given great importance in the Swedish pre-school. This paper is based on a study carried out in one strategically chosen preschool infant group. The study addresses the question of which possible subject positions can be adopted by children during their period of introduction to preschool, their first institutional experience. The focus is on the interaction between teachers and children and between children and social practice. One of the analytical tools used is the concept ”positioning”. The analysis indicates gendered positions for the child as both in need of care and competent. Key words Gender, positioning, preschool, toddlers.
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| 4. |
- Månsson, Annika
(författare)
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Becoming a preschool child - Subjectification in toddlers during their introduction to preschool in a gender perspective
- 2010
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Ingår i: Abstracts;330.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The aim of this presentation is to discuss and problematize children’s introduction to the pre-school as social practice with a focus on subjectification in a gender perspective. This introductory process is to be of great importance in the Swedish preschool. This paper is based on a study carried out in one strategically chosen preschool infant group. The study addresses the question of which possible subject positions can be adopted by children during their introduction period to the preschool, their first institutional practice. What possibilities are offered and what limitations imposed as part of the pedagogical practice? The focus is on the interaction between the teachers and the children and between the children and the social practice. One of the analytical tools used is the concept “positioning”. In my observations I observed gendered positions for the child as both in need of care and competent. Key words: Childhood, childhood care, subjectification, gender, positioning, toddlers.
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| 5. |
- Månsson, Annika, et al.
(författare)
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Democracy in research circles to enable new perspectives on early childhood education and didactics
- 2014
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Ingår i: Educare. - : Malmö högskola, Lärande och Samhälle. - 1653-1868 .- 2004-5190. ; 10:2, s. 39-61
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this article is to examine aspects of democracy derived from partici-pation in so-called research circles, and to discuss participatory and democratic ideas arising in those circles as they relate to perspectives on early childhood education. This paper draws its argument mainly from material recorded from two research circles — one on Gender and the other on New subject didactic challenges in preschool. The analysis was based on the separate data from the two research circles and on a comparison between them. It is a theoretically governed approach based on Klafki’s critical constructive didactics and Biesta’s critical discussion on education and democracy in relation to the rise of neolib-eralism. Larsson’s three aspects of democracy in relation to study circles have been used: equal participation, horizontal relations and knowledge that inform standpoints. The diversity between the circles resulted in variations concerning form and content that could be discussed as related to democracy aspects.
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| 7. |
- Smedman, Annika, et al.
(författare)
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Nutrient density of beverages in relation to climate impact
- 2010
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Ingår i: Food & Nutrition Research. - : SNF Swedish Nutrition Foundation. - 1654-6628 .- 1654-661X. ; 54
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Tidskriftsartikel (refereegranskat)abstract
- The food chain contributes to a substantial part of greenhouse gas (GHG) emissions and growing evidence points to the urgent need to reduce GHGs emissions worldwide. Among suggestions were proposals to alter food consumption patterns by replacing animal foods with more plant-based foods. However, the nutritional dimensions of changing consumption patterns to lower GHG emissions still remains relatively unexplored. This study is the first to estimate the composite nutrient density, expressed as percentage of Nordic Nutrition Recommendations (NNR) for 21 essential nutrients, in relation to cost in GHG emissions of the production from a life cycle perspective, expressed in grams of CO(2)-equivalents, using an index called the Nutrient Density to Climate Impact (NDCI) index. The NDCI index was calculated for milk, soft drink, orange juice, beer, wine, bottled carbonated water, soy drink, and oat drink. Due to low-nutrient density, the NDCI index was 0 for carbonated water, soft drink, and beer and below 0.1 for red wine and oat drink. The NDCI index was similar for orange juice (0.28) and soy drink (0.25). Due to a very high-nutrient density, the NDCI index for milk was substantially higher (0.54) than for the other beverages. Future discussion on how changes in food consumption patterns might help avert climate change need to take both GHG emission and nutrient density of foods and beverages into account.
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| 8. |
- Vallberg, Ann-Christine, et al.
(författare)
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Dokumentation och bedömning i förskolan
- 2010
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Ingår i: Utbildningsvetenskap för förskolan. - : Natur & Kultur. - 9789127121119 ; , s. 229-249
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 9. |
- Vallberg Roth, Ann-Christine, et al.
(författare)
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Individual development plans from a critical didactic perspective : focusing on Montessori- and Reggio Emilia-profiled preschools in Sweden
- 2011
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Ingår i: Journal of Early Childhood Research. - : Sage Publications. - 1476-718X .- 1741-2927. ; 9:3, s. 247-261
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Tidskriftsartikel (refereegranskat)abstract
- Individual development plans, which are sometimes designed as ”agreements - contracts”, can be considered the most rigid type of regulation on the individual level in the history of preschool in Sweden. Today we speak about a deregulated school. This regulation seems to have changed its character, gradually drifting from school regulation to individual and self regulation. The study aims to map and discuss the variation of content and positions for children in the documentation from all preschools in a municipality in the south of Sweden. Documentation and individual development plans (IDP) are studied from preschools with different pedagogical profiles. Materials from Montessori - and Reggio Emilia inspired preschools are focused. A critical didactic perspective refers to a discussion and critical scrutiny of the structure of contents, assessment and position off children in different types of documentation. The perspective leads to questions like: How is content constructed, and what governs the choice of content in IDPs and documentation at the institutional and individual levels? How is content related to pedagogical profile? What identities and positions are formulated for children in relation to various contents and profiles? The empiric in the study was gathered 2008 and comprises text in the form of governing documents on different levels: as municipal guidelines, profile descriptions on the municipality's websites and IDP forms. Tentative results show a variation with both similar and diverse constructions of contents and positions related to pedagogical profiles.
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| 10. |
- Vallberg Roth, Ann-Christine, et al.
(författare)
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Individuella utvecklingsplaner i Montessori- och Reggio Emiliaprofilerade förskolor.
- 2010
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Ingår i: Barndom, lärande och ämnesdidaktik - Exempel från en forskningsmiljö vid Lärarutbildningen. - : Malmö högskola. ; , s. 53-70
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Vad har en förändrad barndom för betydelse för yngre barns lärande och utbildning? Denna rapport försöker förstå och förklara denna betydelse med hjälp av forskare från forskningsfältet Barndom, lärande och ämnesdidaktik på Lärarutbildningen på Malmö högskola. I rapporten tas begreppen barndom, lärande och ämnesdidaktik upp som sammanflätade och ömsesidigt relaterade till varandra. I fem olika artiklar presenteras: Förskolans ledarskap i en nystartad förskola ; Hur dokumentation och bedömning i förskolor med olika pedagogiska inriktningar kan se ut ; En översikt över historiedidaktisk forskning med inriktning mot yngre barn ; Svenskämnesundervisningens innehåll i skolans tidigare år ; En kartläggning av forskning om de yngre barnen i det idrottsvetenskapliga intresseområdet
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