| 1. |
- Fatuzzo, C. G., et al.
(författare)
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Nodal Landau Fermi-liquid quasiparticles in overdoped La1.77Sr0.23CuO4
- 2014
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Ingår i: Physical Review B. Condensed Matter and Materials Physics. - 1098-0121 .- 1550-235X. ; 89:20, s. 205104-
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Tidskriftsartikel (refereegranskat)abstract
- Nodal angle-resolved photoemission spectra taken on overdoped La1.77Sr0.23CuO4 are presented and analyzed. It is proven that the low-energy excitations are true Landau Fermi-liquid quasiparticles. We show that momentum and energy distribution curves can be analyzed self-consistently without quantitative knowledge of the bare band dispersion. Finally, by imposing Kramers-Kronig consistency on the self-energy Sigma, insight into the quasiparticle residue is gained. We conclude by comparing our results to quasiparticle properties extracted from thermodynamic, magnetoresistance, and high-field quantum oscillation experiments on overdoped Tl2Ba2CuO6+delta.
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| 2. |
- Moyano, A. L., et al.
(författare)
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Distribution of C16:0, C18:0, C24:1, and C24:0 sulfatides in central nervous system lipid rafts by quantitative ultra-high-pressure liquid chromatography tandem mass spectrometry
- 2014
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Ingår i: Analytical Biochemistry. - : Elsevier BV. - 0003-2697. ; 467, s. 31-39
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Tidskriftsartikel (refereegranskat)abstract
- Sulfated galactosylceramides (sulfatides) are glycosphingolipids associated with cholesterol- and sphingolipid-enriched membrane microdomains (lipid rafts) and are highly expressed in brain tissue. Although it is known that sulfatide species show heterogeneity in their fatty acid acyl group composition throughout brain development, their lipid raft distribution and biological relevance is poorly understood. We validated a fast and sensitive ultra-high-pressure liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) method to measure developmentally regulated sulfatide species (06:0, C18:0, C24:1, and C24:0) in central nervous system (CNS) lipid rafts isolated without using detergent. Our UHPLC-MS/MS assay showed good accuracy and precision with a linear range of 5 to 1000 nM for C18:0 and C24:1 sulfatides and 10 to 1000 nM for 06:0 and C24:0 sulfatides. We applied this quantitative analysis to detergent-free lipid rafts isolated from wild-type mice and arylsulfatase A-deficient (ASA knockout) mice that accumulate sulfatides. All four sulfatide species were more abundant in raft membranes than in non-raft membranes, with a significant increase in lipid rafts isolated from ASA knockout mice. This is the first description of an analytical method to study these sulfatide species in raft and non-raft membranes and has the potential to be applied to preparations from other tissues.
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| 3. |
- Moyano, A. L., et al.
(författare)
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Levels of plasma sulfatides C18: 0 and C24: 1 correlate with disease status in relapsing-remitting multiple sclerosis
- 2013
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Ingår i: Journal of Neurochemistry. - : Wiley. - 0022-3042. ; 127:5, s. 600-604
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Tidskriftsartikel (refereegranskat)abstract
- Multiple sclerosis (MS) is considered an autoimmune demyelinating disease of the CNS and myelin-derived glycolipids are one of the targets of this autoimmune attack. In this study, we examined for the first time the plasma distribution of sulfatide isoforms. Sulfatides with long-chain (C24:0 or C24:1) and short-chain (C16:0 or C18:0) fatty acids were quantified in plasma of relapsing-remitting MS patients by ultra-high-performance liquid chromatography tandem mass spectrometry. We found that C18:0 and C24:1 sulfatide plasma levels positively correlated with the Expanded Disability Status Scale. C16/C18:0 and C16/C24:0 ratios also correlated with the age and the time since last relapse. Healthy women showed higher levels of C16:0 sulfatide than healthy men; however, this gender difference disappeared in MS patients. Our data underline the potential use of sulfatides as biomarkers in relapsing-remitting MS and points to a possible association with the higher susceptibility of women to develop MS.
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