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- Edenborough, F. P., et al.
(författare)
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Guidelines for the management of pregnancy in women with cystic fibrosis
- 2008
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Ingår i: Journal of Cystic Fibrosis. - : Elsevier BV. - 1569-1993 .- 1873-5010. ; 7 Suppl 1, s. S2-32
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Tidskriftsartikel (refereegranskat)abstract
- Women with cystic fibrosis (CF) now regularly survive into their reproductive years in good health and wish to have a baby. Many pregnancies have been reported in the literature and it is clear that whilst the outcome for the baby is generally good and some mothers do very well, others find either their CF complicates the pregnancy or is adversely affected by the pregnancy. For some, pregnancy may only become possible after transplantation. Optimal treatment of all aspects of CF needs to be maintained from the preconceptual period until after the baby is born. Clinicians must be prepared to modify their treatment to accommodate the changing physiology during pregnancy and to be aware of changing prescribing before conception, during pregnancy, after birth and during breast feeding. This supplement offers consensus guidelines based on review of the literature and experience of paediatricians, adult and transplant physicians, and nurses, physiotherapists, dietitians, pharmacists and psychologists experienced in CF and anaesthetist and obstetricians with experience of CF pregnancy. It is hoped they will provide practical guidelines helpful to the multidisciplinary CF teams caring for pregnant women with CF.
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- MacKenzie, Robert, Professor, et al.
(författare)
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The realities of regulatory change : Beyond the fetish of deregulation
- 2005
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Ingår i: Sociology. - : Sage Publications. - 0038-0385 .- 1469-8684. ; 39:3, s. 499-517
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Tidskriftsartikel (refereegranskat)abstract
- The article argues that any discussion of regulatory change should be sensitive to the manner in which regulation was originally constructed and developed. Any change can only be understood by a mapping of the complex interrelation of spaces, spheres and actors of regulation. The act of regulatory change requires shifts and re-alignments across a wide range of fronts. This is because regulation involves alliances and linkages across a range of spaces and actors, contingent upon the peculiarities and limits of different states and their respective civil societies.The manner in which regulatory change may be prosecuted also belies any notion of unproblematic transfer of responsibilities between actors. Copyright © 2005 BSA Publications Ltd®.
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- Van Raamsdonk, Jeremy M., et al.
(författare)
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Testicular degeneration in Huntington disease
- 2007
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Ingår i: Neurobiology of Disease. - : Elsevier BV. - 0969-9961. ; 26:3, s. 512-520
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Tidskriftsartikel (refereegranskat)abstract
- Huntington disease (HD) is an adult onset, neurodegenerative disorder that results from CAG expansion in the HD gene. Recent work has demonstrated testicular degeneration in mouse models of HD and alterations in the hypothalamic-pituitary-gonadal (HPG) axis in HD patients. Here, we show that HD patients have specific testicular pathology with reduced numbers of germ cells and abnormal seminiferous tubule morphology. In the YAC128 mouse model, testicular degeneration develops prior to 12 months of age, but at 12 months, there is no evidence for decreased testosterone levels or loss of GnRH neurons in the hypothalamus. This suggests that testicular pathology results from a direct toxic effect of mutant huntingtin in the testis and is supported by the fact that huntingtin is highly expressed in the affected cell populations in the testis. Understanding the pathogenesis of HD in the testis may reveal common critical pathways which lead to degeneration in both the brain and testis.
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- Holm, Ida Elisabeth, et al.
(författare)
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A reassessment of the neuropathology of frontotemporal dementia linked to chromosome 3
- 2007
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Ingår i: Journal of Neuropathology and Experimental Neurology. - 1554-6578. ; 66:10, s. 884-891
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Tidskriftsartikel (refereegranskat)abstract
- A large Danish family has previously been reported in which autosomal dominant frontotemporal dementia (FTD) is genetically linked to chromosome 3 (FTD-3). A mutation was recently identified in the CHMP2B gene that is probably responsible for causing disease in this family. Because of its neuropathologic findings, FTD-3 was originally categorized as a subtype of frontotemporal lobar degeneration, termed "dementia lacking distinctive histopathology." We now report a reevaluation of the neuropathologic changes in this family. Postmortem material from 4 affected family members was available for examination. Gross examination revealed generalized cortical atrophy that was most severe in frontal and temporal cortices. Microscopy showed loss of cortical neurons. microvacuolation of layer 11, mild gliosis, and demyelination of the deep white matter. Results of immunohistochemical staining for alpha-synuclein, prion protein, neurofilament, and tau protein were unremarkable. Variable numbers of small, round, ubiquitin-positive cytoplasmic inclusions were present in the dentate granule layer of the hippocampus in all 4 cases. Rare ubiquitin-positive inclusions were also found in frontal and temporal cortical neurons. These inclusions were also positive for p62 but not for TDP-43. The finding of ubiquitin- and p62-positive, TDP-43-neaative cytoplasmic inclusions in the hippocampus and neocortex suggests reclassification of the neuropathology of FTD-3 as a unique subtype of frontotemporal lobar degeneration with ubiquitin-positive inclusions that are TDP-43 -negative.
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- Lim, Jun, et al.
(författare)
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Static and dynamic performance optimisation of a 1.3 mu m GaInNAs ridge waveguide laser
- 2008
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Ingår i: Optical and Quantum Electronics. - : Springer Science and Business Media LLC. - 0306-8919 .- 1572-817X. ; 40:14-15, s. 1181-1186
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Tidskriftsartikel (refereegranskat)abstract
- In this work, we perform a multi-parameter design study to improve the performance of an uncooled directly modulated 1.3 mu m GaInNAs ridge waveguide laser for high speed operation especially at high temperature. The static and dynamic performance of the improved design is analyzed using an accurate in-house 2D electro-opto-thermal laser simulator. The improved structure is shown to have a lower threshold current, higher thermal roll-over limit and higher modulation bandwidth-especially under high temperature operation. The improved structure also has a lower vertical beam divergence compared to a reference structure with a conventional design.
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