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Träfflista för sökning "WFRF:(Magnusson V) srt2:(1984)"

Sökning: WFRF:(Magnusson V) > (1984)

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1.
  • Pyykkö, I., et al. (författare)
  • A reduction of vestibulo-visual integration during transdermally administered scopolamine and dimenhydrinate. A presentation of gain control theory in motion sickness
  • 1984
  • Ingår i: Acta Oto-Laryngologica, Supplement. - : Informa UK Limited. - 0365-5237 .- 0001-6489 .- 1651-2251. ; 406, s. 73-167
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
    • The effect of transdermally administered scopolamine (TTS scopolamine) (release rate 5 micrograms/h) and dimenhydrinate (100 mg) was examined on optovestibular nystagmus in 16 volunteers in a randomized double-blind trial. A statistically significant decrease in the optokinetic part of nystagmus was observed during all treatments. Most profound reduction was found during treatment with two TTS scopolamine. The vestibular part was reduced by treatment with two TTS scopolamine, only. The results indicate that scopolamine and dimenhydrinate exert their effect in motion sickness by reducing the vestibular and visual influx and by partly inhibiting the integrative functioning of the vestibular nuclei. In their action, the motion sickness drugs seem to assist the cerebellum by diminishing impulses from various orientation reflexes in order to preserve the functional capacity of the central nervous system. Different symptoms in motion sickness seem to arise when the vestibular gain operates beyond the normal range of the cerebellar control mechanisms.
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2.
  • Schalén, L, et al. (författare)
  • Intra-individual variation in oculomotor performance in man
  • 1984
  • Ingår i: Acta Oto-Laryngologica, Supplement. - : Informa UK Limited. - 0365-5237 .- 0001-6489 .- 1651-2251. ; 96:S406, s. 7-212
  • Tidskriftsartikel (refereegranskat)abstract
    • Peak velocity of saccade, maximum velocity of smooth pursuit, and peak velocity of slow phase of vestibular and optovestibular nystagmus were measured three times daily on three separate days in 6 healthy subjects in order to estimate the intra-individual variation of the results of oculomotor tests. Analysis of variance revealed that the oculomotor performance of the individual subjects varied systematically, depending on whether the tests were performed in the morning, at noon, or late in the afternoon. In particular, the velocity of saccade displayed lowest values in the afternoon. The present results indicate that oculomotor performance may depend on the individual biological rhythm of fatigue; however, it is also possible that eye motor behaviour is coupled to an independent rhythm of motor activity. Circadian rhythmicity of oculomotor performance should be considered in follow-up studies and in examination of patients with reduced vigilance.
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Pyykkö, I (2)
Schalén, L (2)
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