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Träfflista för sökning "WFRF:(Mahdavi Jafar) srt2:(2020-2023)"

Sökning: WFRF:(Mahdavi Jafar) > (2020-2023)

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1.
  • Okoye, Jennifer C., et al. (författare)
  • Ferric quinate (QPLEX) inhibits the interaction of major outer membrane protein (MOMP) with the Lewis b (Leb) antigen and limits Campylobacter colonization in broilers
  • 2023
  • Ingår i: Frontiers in Microbiology. - : Frontiers Media S.A.. - 1664-302X. ; 14
  • Tidskriftsartikel (refereegranskat)abstract
    • Campylobacter jejuni colonizes hosts by interacting with Blood Group Antigens (BgAgs) on the surface of gastrointestinal epithelia. Genetic variations in BgAg expression affects host susceptibility to C. jejuni. Here, we show that the essential major outer membrane protein (MOMP) of C. jejuni NCTC11168 binds to the Lewis b (Leb) antigen on the gastrointestinal epithelia of host tissues and this interaction can be competitively inhibited by ferric quinate (QPLEX), a ferric chelate structurally similar to bacterial siderophores. We provide evidence that QPLEX competitively inhibits the MOMP-Leb interaction. Furthermore, we demonstrate that QPLEX can be used as a feed additive in broiler farming to significantly reduce C. jejuni colonization. Our results indicate that QPLEX can be a viable alternative to the preventative use of antibiotics in broiler farming to combat C. jejuni infections.
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2.
  • Sayahi, Mohammad Hosein, et al. (författare)
  • Sulfonic acid-functionalized poly(4-styrenesulfonic acid) mesoporous graphene oxide hybrid for one-pot preparation of coumarin-based pyrido[2,3-d]pyrimidine-dione derivatives
  • 2020
  • Ingår i: Research on chemical intermediates (Print). - : SPRINGER. - 0922-6168 .- 1568-5675. ; 46:1, s. 491-507
  • Tidskriftsartikel (refereegranskat)abstract
    • Sulfonic acid-functionalized poly(4-styrenesulfonic acid) mesoporous graphene oxide hybrid (PSSA-MGO) is prepared by polymerization of 4-styrenesulfonic acid on the surface of mesoporous graphene oxide. The catalyst is fully characterized by several methods including Fourier-transform infrared spectroscopy, Brunauer-Emmett-Teller adsorption-desorption analysis, scanning and transmission electron microscopy. PSSA-MGO is used as an efficient acidic catalyst for the one-pot preparation of some novel chromenopyridopyrimidine-dione derivatives via the three-component reaction of 4-aminocoumarin, thiobarbituric acid and aromatic aldehydes. All the obtained products were also characterized. This synthetic procedure presents some advantages including an eco-friendly procedure, high yield of the products and recyclability of the catalyst.
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