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Träfflista för sökning "WFRF:(Mahmoudi M) srt2:(2010-2014)"

Sökning: WFRF:(Mahmoudi M) > (2010-2014)

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  • Cepeda, D., et al. (författare)
  • CDK-mediated activation of the SCFFBXO28 ubiquitin ligase promotes MYC-driven transcription and tumourigenesis and predicts poor survival in breast cancer
  • 2013
  • Ingår i: EMBO Molecular Medicine. - : EMBO. - 1757-4676 .- 1757-4684. ; 5:7, s. 999-1018
  • Tidskriftsartikel (refereegranskat)abstract
    • SCF (Skp1/Cul1/F-box) ubiquitin ligases act as master regulators of cellular homeostasis by targeting key proteins for ubiquitylation. Here, we identified a hitherto uncharacterized F-box protein, FBXO28 that controls MYC-dependent transcription by non-proteolytic ubiquitylation. SCFFBXO28 activity and stability are regulated during the cell cycle by CDK1/2-mediated phosphorylation of FBXO28, which is required for its efficient ubiquitylation of MYC and downsteam enhancement of the MYC pathway. Depletion of FBXO28 or overexpression of an F-box mutant unable to support MYC ubiquitylation results in an impairment of MYC-driven transcription, transformation and tumourigenesis. Finally, in human breast cancer, high FBXO28 expression and phosphorylation are strong and independent predictors of poor outcome. In conclusion, our data suggest that SCFFBXO28 plays an important role in transmitting CDK activity to MYC function during the cell cycle, emphasizing the CDK-FBXO28-MYC axis as a potential molecular drug target in MYC-driven cancers, including breast cancer. FBXO28 is identified as part of a SCF complex acting as a regulator of tumor cell proliferation and an important modifier of MYC function. FBXO28 may be a new prognostic factor in breast cancer and a new potential drug target in MYC- driven tumors.
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  • Akbari, Keramatollah, et al. (författare)
  • Simulation of ventilation effects on indoor radon
  • 2013
  • Ingår i: Management of environmental quality. - : Emerald. - 1477-7835 .- 1758-6119. ; 24:3, s. 394-407
  • Tidskriftsartikel (refereegranskat)abstract
    • Purpose: The purpose of this paper is to describe the use of computational fluid dynamics (CFD) to simulate indoor radon distribution and ventilation effects. This technique was used to predict and visualize radon content and indoor air quality in a one-family detached house in Stockholm. The effects of intake fans, exhaust fans and doors on radon concentration were investigated. Design/methodology/approach: In this study a mechanically balanced ventilation system and a continuous radon monitor (CRM) were used to measure the indoor ventilation rate and radon levels. In a numerical approach, the FLUENT CFD package was used to simulate radon entry into the building and ventilation effects. Findings: Results of the numerical study indicated that indoor pressure created by ventilation systems and infiltration through doors or windows have significant effects on indoor radon content. The location of vents was found to affect the indoor radon level and distribution. Research limitations/implications: It may be possible to improve any discrepancies found in this article by using a more refined representation of grids and certain boundary conditions, such as pressure and temperature differences between inside and outside and by considering some real situations in residential buildings and external situations. Originality/value: From the viewpoints of indoor air quality (IAQ) and energy savings, ventilation has two opposing functions; on the positive side it enhances IAQ and the establishment of thermal comfort, and on the negative side it increases energy consumption. This paper describes the search for a solution to cope with this contradiction.
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  • Resultat 1-10 av 18

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