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Gestational diabete...
Gestational diabetes and maternal obesity are associated with epigenome-wide methylation changes in children
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- Hjort, Line (författare)
- University of Copenhagen,Copenhagen University Hospital
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- Martino, David (författare)
- Murdoch Children's Research Institute,University of Melbourne
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- Grunnet, Louise Groth (författare)
- Copenhagen University Hospital
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- Naeem, Haroon (författare)
- University of Melbourne,Murdoch Children's Research Institute,Monash University
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- Maksimovic, Jovana (författare)
- University of Melbourne,Murdoch Children's Research Institute
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- Olsson, Anders Henrik (författare)
- Copenhagen University Hospital
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- Zhang, Cuilin (författare)
- National Institute of Child Health and Human Development
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- Ling, Charlotte (författare)
- Lund University,Lunds universitet,Diabetes - epigenetik,Forskargrupper vid Lunds universitet,Diabetes - Epigenetics,Lund University Research Groups
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- Olsen, Sjurdur Frodi (författare)
- Danish Serum Institute, Copenhagen
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- Saffery, Richard (författare)
- Murdoch Children's Research Institute,University of Melbourne
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- Vaag, Allan Arthur (författare)
- Copenhagen University Hospital,AstraZeneca, Sweden
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(creator_code:org_t)
- 2018-09-06
- 2018
- Engelska.
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Ingår i: JCI Insight. - : American Society for Clinical Investigation. - 2379-3708. ; 3:17
- Relaterad länk:
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http://dx.doi.org/10...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Offspring of women with gestational diabetes mellitus (GDM) are at increased risk of developing metabolic disease, potentially mediated by epigenetic mechanisms. We recruited 608 GDM and 626 control offspring from the Danish National Birth Cohort, aged between 9 and 16 years. DNA methylation profiles were measured in peripheral blood of 93 GDM offspring and 95 controls using the Illumina HumanMethylation450 BeadChip. Pyrosequencing was performed for validation/replication of putative GDM-associated, differentially methylated CpGs in additional 905 offspring (462 GDM, 444 control offspring). We identified 76 differentially methylated CpGs in GDM offspring compared with controls in the discovery cohort (FDR, P < 0.05). Adjusting for offspring BMI did not affect the association between methylation levels and GDM status for any of the 76 CpGs. Most of these epigenetic changes were due to confounding by maternal prepregnancy BMI; however, 13 methylation changes were independently associated with maternal GDM. Three prepregnancy BMI-associated CpGs (cg00992687 and cg09452568 of ESM1 and cg14328641 of MS4A3) were validated in the replication cohort, while cg09109411 (PDE6A) was found to be associated with GDM status. The identified methylation changes may reflect developmental programming of organ disease mechanisms and/or may serve as disease biomarkers.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Nyckelord
- Diabetes
- Embryonic development
- Endocrinology
- Epigenetics
- Genetics
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Hjort, Line
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Martino, David
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Grunnet, Louise ...
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Naeem, Haroon
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Maksimovic, Jova ...
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Olsson, Anders H ...
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Zhang, Cuilin
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Ling, Charlotte
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Olsen, Sjurdur F ...
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Saffery, Richard
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Vaag, Allan Arth ...
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