| 1. |
- Gretarsdottir, Solveig, et al.
(författare)
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Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm
- 2010
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 42:8, s. 71-692
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Tidskriftsartikel (refereegranskat)abstract
- We performed a genome-wide association study on 1,292 individuals with abdominal aortic aneurysms (AAAs) and 30,503 controls from Iceland and The Netherlands, with a follow-up of top markers in up to 3,267 individuals with AAAs and 7,451 controls. The A allele of rs7025486 on 9q33 was found to associate with AAA, with an odds ratio (OR) of 1.21 and P = 4.6 x 10(-10). In tests for association with other vascular diseases, we found that rs7025486[A] is associated with early onset myocardial infarction (OR = 1.18, P = 3.1 x 10(-5)), peripheral arterial disease (OR = 1.14, P = 3.9 x 10(-5)) and pulmonary embolism (OR = 1.20, P = 0.00030), but not with intracranial aneurysm or ischemic stroke. No association was observed between rs7025486[A] and common risk factors for arterial and venous diseases-that is, smoking, lipid levels, obesity, type 2 diabetes and hypertension. Rs7025486 is located within DAB2IP, which encodes an inhibitor of cell growth and survival.
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| 2. |
- Assimes, Themistocles L., et al.
(författare)
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Lack of Association Between the Trp719Arg Polymorphism in Kinesin-Like Protein-6 and Coronary Artery Disease in 19 Case-Control Studies
- 2010
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Ingår i: Journal of the American College of Cardiology. - : Elsevier BV. - 0735-1097. ; 56:19, s. 1552-1563
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Tidskriftsartikel (refereegranskat)abstract
- Objectives We sought to replicate the association between the kinesin-like protein 6 (KIF6) Trp719Arg polymorphism (rs20455), and clinical coronary artery disease (CAD). Background Recent prospective studies suggest that carriers of the 719Arg allele in KIF6 are at increased risk of clinical CAD compared with noncarriers. Methods The KIF6 Trp719Arg polymorphism (rs20455) was genotyped in 19 case-control studies of nonfatal CAD either as part of a genome-wide association study or in a formal attempt to replicate the initial positive reports. Results A total of 17,000 cases and 39,369 controls of European descent as well as a modest number of South Asians, African Americans, Hispanics, East Asians, and admixed cases and controls were successfully genotyped. None of the 19 studies demonstrated an increased risk of CAD in carriers of the 719Arg allele compared with noncarriers. Regression analyses and fixed-effects meta-analyses ruled out with high degree of confidence an increase of >= 2% in the risk of CAD among European 719Arg carriers. We also observed no increase in the risk of CAD among 719Arg carriers in the subset of Europeans with early-onset disease (younger than 50 years of age for men and younger than 60 years of age for women) compared with similarly aged controls as well as all non-European subgroups. Conclusions The KIF6 Trp719Arg polymorphism was not associated with the risk of clinical CAD in this large replication study. (J Am Coll Cardiol 2010;56:1552-63) (C) 2010 by the American College of Cardiology Foundation
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| 3. |
- McKelvey, Maureen, 1965, et al.
(författare)
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Conceptualizing Knowledge Intensive Entrepreneurship: Concepts and Models.
- 2010
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Ingår i: Aegis conference - 7th Framework Programme for Research and Technological Development..
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Konferensbidrag (refereegranskat)abstract
- This paper examines knowledge intensive entrepreneurship in various ways and represents a broad framework within which the AEGIS project will take place. Knowledgeintensive entrepreneurship is considered a key socio-economic phenomenon that drives innovation, and economic growth, and is at the base of the competitiveness of countries. After an initial definition of knowledge intensive entrepreneurship and the main concepts, in Section 1 we will present the proposed conceptual framework that will guide our research. Then in Section 2 we will concentrate on what the literature has said about entrepreneurship: we will divide the brief survey into economics (section 2.1), industrial dynamics (section 2.2) and innovation management (section 2.3). We will then turn into what has already been researched about knowledge intensive entrepreneurship by examining KEINS, an EU exploratory project carried out in the last years (section 3). Following a presentation of the main results from KEINS, we will introduce the main points of AEGIS, centered on linking firms, knowledge and systems (section 4). Finally, in the last section, we will focus on analyzing the phenomenon of KIE. This includes first an examination of the various empirical dimensions of AEGIS in its attempts to develop indicators to explore, identify and measure knowledge intensive entrepreneurship. We then conclude with some final considerations
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| 4. |
- McKelvey, Maureen, 1965, et al.
(författare)
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Conceptualizing Knowlege Intensive Entrepreneurship: Concepts and Models
- 2011
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Ingår i: AEGIS Deliverables and Reports Series.
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- This AEGIS article examines knowledge intensive entrepreneurship in various ways. It presents a model and represents a broad framework for understanding. Knowledgeintensive entrepreneurship is considered a key socio-economic phenomenon that drives innovation, and economic growth, and is at the base of the competitiveness of countries. An initial definition of knowledge intensive entrepreneurship and the main concepts is in Section 1. We then present the proposed conceptual framework that will guide our research. Then in Section 2 we concentrate on what the literature has said about entrepreneurship: This is divided into the brief survey into economics (section 2.1), industrial dynamics (section 2.2) and innovation management (section 2.3). The article then turn into what has already been researched about knowledge intensive entrepreneurship by examining KEINS, an EU exploratory project carried out in the last years (section 3). Following a presentation of the main results from KEINS, we will introduce the main points of AEGIS, centered on linking firms, knowledge and systems (section 4). Finally, in the last section, we will focus on analyzing the phenomenon of KIE. This includes first an examination of the various empirical dimensions of AEGIS in its attempts to develop indicators to explore, identify and measure knowledge intensive entrepreneurship. The paper then concludes with some final considerations
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