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- Malm, B. Gunnar, et al.
(författare)
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Implanted collector profile optimization in a SiGeHBT process
- 2001
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Ingår i: Solid-State Electronics. - 0038-1101 .- 1879-2405. ; 45:3, s. 399-404
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Tidskriftsartikel (refereegranskat)abstract
- Optimization of implanted collector doping profiles for a high-speed, low-voltage SiGe HBT process has been investigated experimentally and by device simulations. A low-energy antimony implantation has been combined with a standard selectively implanted collector using phosphorous, to achieve improved control of the collector doping profile. The simulations indicate that the narrow n-type doping peak formed by the antimony implantation allows the cut-off frequency f(T) to be increased without degrading the collector emitter breakdown voltage BVCEO. The fabricated devices demonstrate a highest f(T) of 60 GHz. Depending on the collector profile BVCEO values between 1.5 and 2 V were obtained.
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- Billstrom, R., et al.
(författare)
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Acute myeloid leukemia with inv(16)(p13q22) : Involvement of cervical lymph nodes and tonsils is common and may be a negative prognostic sign
- 2002
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Ingår i: American Journal of Hematology. - : Wiley. - 0361-8609 .- 1096-8652. ; 71:1, s. 15-19
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Tidskriftsartikel (refereegranskat)abstract
- Acute myeloid leukemia (AML) with inv(16)(p13q22) or the variant t(16,16)(p13,q22), is strongly associated with the FAB subtype M4Eo. A high incidence of CNS involvement was reported in the 1980s, but otherwise little is known about the pattern of extamedullary leukemia (EML) manifestations in this AML type. We have compiled clinical and cytogenetic data on 27 consecutive AML cases with inv(16)/t(16,16) from southern Sweden. In general, these AMLs displayed the clinical features that have previously been described as characteristic for this disease entity: low median age, hyperleukocytosis, M4Eo morphology, and a favorable prognosis. However, CNS leukemia was only seen in relapse in one patient diagnosed in 1980, whereas the most common EML manifestation in our series was lymphadenopathy (5/27, 19%), most often cervical with or without gross tonsillar enlargement. A review of previously published, clinically informative cases corroborates that lymphadenopathy, with preference for the cervical region, is the most common EML at diagnosis in inv(16)-positive AML (58/175, 33%). CNS leukemia, on the other hand, has been reported in only 17% of the cases, mostly in the relapse setting, with a diminishing frequency over time, possibly due to protective effects of high-dose cytarabine. Other reported EML sites include the scalp, ovaries, and the intestine. Cervicotonsillar EML was in our series associated with a shorter duration of first remission, (P< 0.05), and may hence prove to be an important clinical parameter when deciding treatment strategies in AML with inv(16)/t(16,16). © 2002 Wiley-Liss, Inc.
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- Haralson, Erik, et al.
(författare)
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Influence of self heating in a BiCMOS on SOI technology
- 2004
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Ingår i: ESSCIRC 2004. - NEW YORK : IEEE. - 0780384784 ; , s. 337-340
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Konferensbidrag (refereegranskat)abstract
- Self heating in a 0.25mum BiCMOS technology with different isolation structures is characterized. Thermal resistance values for single- and multiple-emitter devices are extracted and reported. The dependence of the thermal resistance on the emitter aspect ratio is critical to take into consideration when determining the isolation scheme for devices. 2-D electro-thermal simulations are performed and compared to experimental results. The impact of metallization on the self-heating in the device is examined through simulations.
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- Isaeus, M., et al.
(författare)
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Effects of filamentous algae and sediment on recruitment and survival of Fucus serratus (Phaeophyceae) juveniles in the eutrophic Baltic Sea
- 2004
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Ingår i: European journal of phycology. - 0967-0262 .- 1469-4433. ; 39:3, s. 301-307
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Tidskriftsartikel (refereegranskat)abstract
- Eutrophication of the Baltic Sea has increased both the growth of annual filamentous algae and the rate of sedimentation. Together these factors may have a detrimental effect on the survival of perennial macroalgal populations. The aim of this research was to study how these factors affect the colonization success of Fucus serratus at the local level. We investigated the settlement and survival of F. serratus germlings through a combination of field studies and laboratory experiments. The study area lay off the east coast of Oland, along the central Baltic Sea, where consistently-submerged, extensive fucoid stands occur at depths of 2- 10 in, together with turf-forming filamentous algae, mainly Polysiphonia fucoides. Very few F. serratus juveniles were observed outside the sweeping radius of adult F. serratus individuals at a 7-m depth, while abundant recruits were found inside F. serratus stands. Amounts of filamentous algae and sediment were significantly larger outside the F. serratus stands than inside, and the amount of fine sediment (< 0.25 mm) was positively correlated with the amount of filamentous algae, suggesting that fine sediment accumulates in the turf. Experimental studies showed that both filamentous algae and sediment negatively affect the settlement ability of F. serratus eggs and zygotes and the subsequent survival of the germlings, with sediment having the strongest effect. Thus, the prior existence of an adult F. serratus population may allow for continuing recruitment of juveniles, while colonization of new areas unaffected by the sweeping effect of larger individuals seems very difficult under current conditions.
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- Johansson, Björn, et al.
(författare)
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Alpha-1-antitrypsin is present in the specific granules of human eosinophilic granulocytes
- 2001
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Ingår i: Clinical and Experimental Allergy. - : Wiley. - 1365-2222 .- 0954-7894. ; 31:3, s. 379-386
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Tidskriftsartikel (refereegranskat)abstract
- Eosinophils may be found at sites of inflammation, for example in asthma, allergy and helminthic infestation, but their role in human inflammatory disease is unclear. In the present study, we investigated the presence of alpha-1-antitrypsin (AAT), a serine proteinase inhibitor, in human eosinophils. When lysates of highly purified eosinophils were subjected to Western blotting, with a chemiluminescent substrate, immunoreactive bands were seen. An ELISA was developed to measure the AAT content, which was found to be about 100 ng/5 x 106 eosinophils, about 50 ng/5 x 106 neutrophils, and about 25 ng/5 x 106 monocytes. Immunoelectron microscopy showed localization of AAT to the specific granules of eosinophils. During prolonged incubation of eosinophils, no significant increase in the total amount of AAT could be detected by ELISA. However, there was an increased level of AAT in the medium, in parallel with a decrease in the intracellular AAT content, suggesting release of preformed AAT. Apparent complex formation between iodinated elastase and AAT in eosinophil lysates provided evidence that the AAT is functionally active. On the basis of these findings it is suggested that by releasing AAT, eosinophils may, in a microenvironment, play a role in counteracting the tissue damage caused by serine proteinases released by neutrophils in inflammatory conditions.
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