SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Malmquist J) srt2:(1995-1999)"

Sökning: WFRF:(Malmquist J) > (1995-1999)

  • Resultat 1-7 av 7
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Olsson, P., et al. (författare)
  • Uptake, toxicity and radiation effects of the boron compounds DAAC-1 and DAC-1 in cultured human glioma cells
  • 1998
  • Ingår i: International Journal of Radiation Biology. - 0955-3002 .- 1362-3095. ; 73:1, s. 103-112
  • Tidskriftsartikel (refereegranskat)abstract
    • PURPOSE: To study the uptake, toxicity and radiation effects in vitro of a diol-amino acid-carborane (DAAC-1) and make comparisons with the previously studied diol-amine-carborane (DAC-1). MATERIALS AND METHODS: Toxicity and radiation effects were studied with clonogenic survival, uptake by measuring the cellular boron content and the subcellular distribution was investigated after organelle separation with centrifugation. The studied cell line was human glioma U343. RESULTS: DAAC-1 showed an accumulation of 1-1.5 times, compared with the culture medium, and was non-toxic up to 47 microg boron/ml. The accumulation of DAC-1 was about 90 times, but toxic effects were detectable already at the concentration 5 microg boron/ml. None of the compounds was localized in the cell nucleus. Following irradiation with thermal neutrons, DAC-1 was about 2.5 times more effective than DAAC-1 and about 4.9 times more effective than neutrons alone, at the survival level 0.2. The dose modifying factors, when compared with the neutron beam alone, were for both DAAC-1 and DAC-1 about 1.5 and about 5 when compared with 60Co-gamma-radiation. CONCLUSIONS: DAAC-1 was less toxic than DAC-1 but gave less accumulation of boron. Both substances gave significant boron-dependent cell inactivation when the test cells were exposed to thermal neutrons.
  •  
2.
  •  
3.
  •  
4.
  •  
5.
  • Malmquist, J, et al. (författare)
  • Asymmetric synthesis of p-carboranylalanine (p-Car) and 2-methyl-o-carboranylalanine (Me-o-Car).
  • 1996
  • Ingår i: TETRAHEDRON. - : PERGAMON-ELSEVIER SCIENCE LTD. ; 52:27
  • Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
    • Two new alpha-amino acids containing the 1,2- and the 1,12-dicarba-closo-dodecaborane(12) cages, namely p-carboranylalanine (1), and 2-methyl-o-carboranylalanine (2), were prepared using Oppolzer's sultam methodologies. Copyright (C) 1996 Elsevier Scienc
  •  
6.
  •  
7.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-7 av 7

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy