| 1. |
- Murphy, Fionnuala C., et al.
(författare)
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SenseCam, imagery and bias in memory for wellbeing
- 2011
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Ingår i: Memory. - : PSYCHOLOGY PRESS. - 0965-8211 .- 1464-0686. ; 19:7, s. 768-777
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Tidskriftsartikel (refereegranskat)abstract
- Identifying and modifying the negative interpretation bias that characterises depression is central to successful treatment. While accumulating evidence indicates that mental imagery is particularly effective in the modification of emotional bias, this research typically incorporates static and unrelated ambiguous stimuli. SenseCam technology, and the resulting video-like footage, offers an opportunity to produce training stimuli that are dynamic and self-relevant. Here participants experienced several ambiguous tasks and subsequently viewed SenseCam footage of the same tasks, paired with negative or positive captions. Participants were trained to use mental imagery to inter-relate SenseCam footage and captions. Participants reported increased levels of happy mood, reduced levels of sad mood, and increased task enjoyment following SenseCam review with positive versus negative captions. This shift in emotional bias was also evident at 24-hour follow-up, as participants recollected greater task enjoyment for those tasks previously paired with positive captions. Mental imagery appears to play an important role in this process. These preliminary results indicate that in healthy volunteers, SenseCam can be used within a bias modification paradigm to shift mood and memory for wellbeing associated with performing everyday activities. Further refinements are necessary before similar methods can be applied to individuals suffering from subclinical and clinical depression.
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| 2. |
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| 3. |
- Ambrosini, Valentina, et al.
(författare)
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Consensus on molecular imaging and theranostics in neuroendocrine neoplasms
- 2021
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Ingår i: European Journal of Cancer. - : Elsevier. - 0959-8049 .- 1879-0852. ; 146, s. 56-73
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Forskningsöversikt (refereegranskat)abstract
- Nuclear medicine plays an increasingly important role in the management neuroendocrine neoplasms (NEN). Somatostatin analogue (SSA)-based positron emission tomography/computed tomography (PET/CT) and peptide receptor radionuclide therapy (PRRT) have been used in clinical trials and approved by the European Medicines Agency (EMA) and the US Food and Drug Administration (FDA). European Association of Nuclear Medicine (EANM) Focus 3 performed a multidisciplinary Delphi process to deliver a balanced perspective on molecular imaging and radionuclide therapy in well-differentiated neuroendocrine tumours (NETs). NETs form in cells that interact with the nervous system or in glands that produce hormones. These cells, called neuroendocrine cells, can be found throughout the body, but NETs are most often found in the abdomen, especially in the gastrointestinal tract. These tumours may also be found in the lungs, pancreas and adrenal glands. In addition to being rare, NETs are also complex and may be difficult to diagnose. Most NETs are non-functioning; however, a minority present with symptoms related to hypersecretion of bioactive compounds. NETs often do not cause symptoms early in the disease process. When diagnosed, substantial number of patients are already found to have metastatic disease. Several societies' guidelines address Neuroendocrine neoplasms (NENs) management; however, many issues are still debated, due to both the difficulty in acquiring strong clinical evidence in a rare and heterogeneous disease and the different availability of diagnostic and therapeutic options across countries. EANM Focus 3 reached consensus on employing 68gallium-labelled somatostatin analogue ([68Ga]Ga-DOTA-SSA)-based PET/CT with diagnostic CT or magnetic resonance imaging (MRI) for unknown primary NET detection, metastatic NET, NET staging/restaging, suspected extra-adrenal pheochromocytoma/paraganglioma and suspected paraganglioma. Consensus was reached on employing 18fluorine-fluoro-2-deoxyglucose ([18F]FDG) PET/CT in neuroendocrine carcinoma, G3 NET and in G1-2 NET with mismatched lesions (CT-positive/[68Ga]Ga-DOTA-SSA-negative). Peptide receptor radionuclide therapy (PRRT) was recommended for second line treatment for gastrointestinal NET with [68Ga]Ga-DOTA-SSA uptake in all lesions, in G1/G2 NET at disease progression, and in a subset of G3 NET provided all lesions are positive at [18F]FDG and [68Ga]Ga-DOTA-SSA. PRRT rechallenge may be used for in patients with stable disease for at least 1 year after therapy completion. An international consensus is not only a prelude to a more standardised management across countries but also serves as a guide for the direction to follow when designing new research studies.
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| 4. |
- Ambrosini, Valentina, et al.
(författare)
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Use and perceived utility of [18 F]FDG PET/CT in neuroendocrine neoplasms : A consensus report from the European Neuroendocrine Tumor Society (ENETS) Advisory Board Meeting 2022.
- 2024
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Ingår i: Journal of neuroendocrinology. - 0953-8194 .- 1365-2826. ; 36:1, s. e13359-
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Tidskriftsartikel (refereegranskat)abstract
- Somatostatin receptor (SST) PET/CT is the gold standard for well-differentiated neuroendocrine tumours (NET) imaging. Higher grades of neuroendocrine neoplasms (NEN) show preferential [18F]FDG (FDG) uptake, and even low-grade NET may de-differentiate over time. FDG PET/CT's prognostic role is widely accepted; however, its impact on clinical decision-making remains controversial and its use varies widely. A questionnaire-based survey on FDG PET/CT use and perceived decision-making utility in NEN was submitted to the ENETS Advisory Board Meeting attendees (November 2022, response rate = 70%). In 3/15 statements, agreement was higher than 75%: (i) FDG was considered useful in NET, irrespective of grade, in case of mis-matched lesions (detectable on diagnostic CT but negative/faintly positive on SST PET/CT), especially if PRRT is contemplated (80%); (ii) in NET G3 if curative surgery is considered (82%); and (iii) in NEC prior to surgery with curative intent (98%). FDG use in NET G3, even in the presence of matched lesions, as a baseline for response assessment was favoured by 74%. Four statements obtained more than 60% consensus: (i) FDG use in NET G3 if locoregional therapy is considered (65%); (ii) in neuroendocrine carcinoma before initiating active therapy as a baseline for response assessment (61%); (iii) biopsy to re-assess tumour grade prior to a change in therapeutic management (68%) upon detection of FDG-positivity on the background of a prior G1-2 NET; (iv) 67% were in favour to reconsider PRRT to treat residual SST-positive lesions after achieving complete remission on FDG of the SST-negative disease component. Multidisciplinary opinion broadly supports the use of FDG PET/CT for characterisation of disease biology and to guide treatment selection across a range of indications, despite the lack of full consensus in many situations. This may reflect existing clinical access due to lack of reimbursement or experience with this investigation, which should be addressed by further research.
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| 5. |
- Ambrosio, Fabrisia, et al.
(författare)
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The effect of muscle loading on skeletal muscle regenerative potential : an update of current research findings relating to aging and neuromuscular pathology
- 2009
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Ingår i: American Journal of Physical Medicine & Rehabilitation. - Baltimore : Lippincott Williams & Wilkins. - 0894-9115 .- 1537-7385. ; 88:2, s. 145-155
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Forskningsöversikt (refereegranskat)abstract
- Skeletal muscle is a dynamic tissue with a remarkable ability to continuously respond to environmental stimuli. Among its adaptive responses is the widely investigated ability of skeletal muscle to regenerate after loading or injury or both. Although significant basic science efforts have been dedicated to better understand the underlying mechanism controlling skeletal muscle regeneration, there has been relatively little impact in the clinical approaches used to treat skeletal muscle injuries and wasting. The purpose of this review article is to provide an overview of the basic biology of satellite cell function in response to muscle loading and to relate these findings in the context of aging and neuromuscular pathology for the rehabilitation medicine specialist.
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| 6. |
- Ambrosio, M, et al.
(författare)
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Atmospheric neutrino oscillations from upward throughgoing muon multiple scattering in MACRO
- 2003
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Ingår i: Physics Letters B. - 0370-2693 .- 1873-2445. ; 566:1-2, s. 35-44
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Tidskriftsartikel (refereegranskat)abstract
- The energy of atmospheric neutrinos detected by MACRO was estimated using multiple Coulomb scattering of upward throughgoing muons. This analysis allows a test of atmospheric neutrino oscillations, relying on the distortion of the muon energy distribution. These results have been combined with those coming from the upward throughgoing muon angular distribution only. Both analyses are independent of the neutrino flux normalization and provide strong evidence, above the for level, in favour of neutrino oscillations. (C) 2003 Published by Elsevier B.V.
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| 7. |
- Ambrosini, Lorenzo, et al.
(författare)
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Data Bricks Space Mission: Teaching Kids about Data with Physicalization
- 2022
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Ingår i: 2022 IEEE Workshop on Visualization for Social Good (VIS4Good). - 9781665494212 - 9781665494229
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Konferensbidrag (refereegranskat)abstract
- The Data Bricks Space Mission is a prototype activity based on data physicalization for teaching kids about data. The design of the activity is based on a literature review and interviews with elementary school teachers, and targets kids aged 10-12. Using Lego bricks and a fictional space adventure story, teachers can use the Data Bricks Space Mission activity to empower kids to produce data, communicate their findings, and gain a better understanding of the relationship between data and the world around them.
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| 8. |
- Ambrosio, Francesco, et al.
(författare)
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Strong Hole Trapping Due to Oxygen Dimers in BiVO4: Effect on the Water Oxidation Reaction
- 2019
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Ingår i: Journal of Physical Chemistry Letters. - : American Chemical Society (ACS). - 1948-7185. ; 10:22, s. 7113-7118
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Tidskriftsartikel (refereegranskat)abstract
- We present a study of hole bipolarons in BiVO4. We show that in the presence of two holes O-O dimers are formed, leading to strong charge trapping. While the formation of bipolarons in bulk BiVO4 requires overcoming a kinetic barrier, we find that these defects should be spontaneously formed at the surface of the material and its interface with water. Through molecular dynamics simulations, we study the effect of bipolarons on the water-splitting reaction and show that their presence may be especially beneficial in alkaline conditions.
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| 9. |
- Toft, Fredrik, 1986, et al.
(författare)
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Feasibility study of FPGA-based equalizer for 112-Gbit/s optical fiber receivers
- 2012
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Ingår i: ISCAS 2012 - 2012 IEEE International Symposium on Circuits and Systems. - 9781467302180 ; , s. 3234-3237
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Konferensbidrag (refereegranskat)abstract
- With ever increasing demands on spectral efficiency, complex modulation schemes are being introduced in fiber communication. However, these schemes are challenging to implement as they drastically increase the computational burden at the fiber receiver's end. We perform a feasibility study of implementing a 16-QAM112-Gbit/s decision directed equalizer on a state-of-the-art FPGA platform. An FPGA offers the reconfigurability needed to allow for modulation scheme updates, however, its clock rate is limited. For this purpose, we introduce a new phase correction technique to significantly relax the delay requirement on the critical phase-recovery feedback loop.
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| 10. |
- Stoor, Krister, 1959-
(författare)
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Svenska kyrkan och jojken
- 2016. - 1
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Ingår i: De historiska relationerna mellan Svenska kyrkan och samerna. - Skellefteå : Artos & Norma bokförlag. - 9789175807959 ; , s. 711-734
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Bokkapitel (refereegranskat)abstract
- Jojken är ett muntligt uttryck bland samer som funnits sedan urminnes tider. Att jojka var ett sätt att berätta och beskriva djur, människor, händelser, supranormala relationer etc. Eftersom jojken också användes som verktyg för nåjder eller personer med liknande kunskaper för att nå andra medium, blev jojken stämplad av kyrkan under 1600-talet som ett djävulens verk. Under lång tid var detta uttryckssätt förbjudet och straffbart. Men jojken försvann inte. Den levde sitt liv i det inofficiella rummet, långt borta ifrån den styrande eliten som oftast fanns vid kusten. Syndastämpeln som kyrkan så skickligt implanterat blev så småningom samernas egen syn på jojk på många håll. Trots det, när man studerar äldre inspelningar från början av 1910-talet och anteckningar från slutet av 1800-talet, ser man att många präster, särskilt i norra Västerbotten och södra Norrbotten varit mer än aktiva att dokumentera jojk. De har även blivit tillägnade egna melodier, det förnämsta man som jojkutövare någonsin kan skänka någon. Till och med bland læstadianska predikanter har det förekommit att man accepterat jojkning. "Jojkning är inte syndigt, blott man inte jojkar syndigt, liksom det ej heller är syndigt att dricka tvenne supar när det är kallt." Studien granskar jojkens roll hos den samiska befolkningen i relation till kyrkans folk, med fokus på 1900-talets utveckling.
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