| 1. |
- Ludvigsson, Johnny, et al.
(författare)
-
GAD65 antigen therapy in recently diagnosed type 1 diabetes mellitus
- 2012
-
Ingår i: New England Journal of Medicine. - : Massachusetts Medical Society. - 0028-4793 .- 1533-4406. ; 366:5, s. 433-442
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The 65-kD isoform of glutamic acid decarboxylase (GAD65) is a major autoantigen in type 1 diabetes. We hypothesized that alum-formulated GAD65 (GAD-alum) can preserve beta-cell function in patients with recent-onset type 1 diabetes.METHODS: We studied 334 patients, 10 to 20 years of age, with type 1 diabetes, fasting C-peptide levels of more than 0.3 ng per milliliter (0.1 nmol per liter), and detectable serum GAD65 autoantibodies. Within 3 months after diagnosis, patients were randomly assigned to receive one of three study treatments: four doses of GAD-alum, two doses of GAD-alum followed by two doses of placebo, or four doses of placebo. The primary outcome was the change in the stimulated serum C-peptide level (after a mixed-meal tolerance test) between the baseline visit and the 15-month visit. Secondary outcomes included the glycated hemoglobin level, mean daily insulin dose, rate of hypoglycemia, and fasting and maximum stimulated C-peptide levels.RESULTS: The stimulated C-peptide level declined to a similar degree in all study groups, and the primary outcome at 15 months did not differ significantly between the combined active-drug groups and the placebo group (P=0.10). The use of GAD-alum as compared with placebo did not affect the insulin dose, glycated hemoglobin level, or hypoglycemia rate. Adverse events were infrequent and mild in the three groups, with no significant differences.CONCLUSIONS: Treatment with GAD-alum did not significantly reduce the loss of stimulated C peptide or improve clinical outcomes over a 15-month period.
|
|
| 2. |
- Gyllenberg, A, et al.
(författare)
-
Age-dependent variation of genotypes in MHC II transactivator gene (CIITA) in controls and association to type 1 diabetes
- 2012
-
Ingår i: Genes and Immunity. - Stockholm : Springer Science and Business Media LLC. - 1476-5470 .- 1466-4879. ; 76:2, s. 202-203
-
Tidskriftsartikel (refereegranskat)abstract
- The major histocompatibility complex class II transactivator (CIITA) gene (16p13) has been reported to associate with susceptibility to multiple sclerosis, rheumatoid arthritis and myocardial infarction, recently also to celiac disease at genome-wide level. However, attempts to replicate association have been inconclusive. Previously, we have observed linkage to the CIITA region in Scandinavian type 1 diabetes (T1D) families. Here we analyze five Swedish T1D cohorts and a combined control material from previous studies of CIITA. We investigate how the genotype distribution within the CIITA gene varies depending on age, and the association to T1D. Unexpectedly, we find a significant difference in the genotype distribution for markers in CIITA (rs11074932, P=4 × 10(-5) and rs3087456, P=0.05) with respect to age, in the collected control material. This observation is replicated in an independent cohort material of about 2000 individuals (P=0.006, P=0.007). We also detect association to T1D for both markers, rs11074932 (P=0.004) and rs3087456 (P=0.001), after adjusting for age at sampling. The association remains independent of the adjacent T1D risk gene CLEC16A. Our results indicate an age-dependent variation in CIITA allele frequencies, a finding of relevance for the contrasting outcomes of previously published association studies.
|
|
| 3. |
- Akram, Asif, 1978-, et al.
(författare)
-
A Research Framework to Study how Digital Service Innovation Transforms Value Networks
- 2011
-
Ingår i: Proceedings of IRIS 2011. - Turku, Finland : Turku Center for Computer Science. - 9789521226489 ; , s. 29-40
-
Konferensbidrag (refereegranskat)abstract
- This paper reports from preparations in an ongoing research study concerning how digital service innovation transforms value networks in manufacturing industries. The research study is in the context of the vehicle industry and concerns digital e-maintenance services based on remote diagnostics systems. This digital service innovation in particular is of great importance since manufacturing industries have great potential to expand their business and found new and extended boundaries and relationships with other stakeholder in a network they are attached to. Core challenges and opportunities for digital service innovation will lead us to the study of its influence on the business and innovation environment i.e. the value network. This paper presents a framework to study how digital service innovation transforms value networks based on literature reviews on value network, digital innovation and transformation of value networks.
|
|
| 4. |
- Akram, Asif, 1978-, et al.
(författare)
-
Digital Visions vs. Product Practices : Understanding Tensions in Incumbent Manufacturing Firms
- 2014
-
Ingår i: Proceedings of the Annual Hawaii International Conference on System Sciences. - Los Alamitos, CA : IEEE Computer Society. - 9781479925049 - 9781479925056 ; , s. 4516-4525
-
Konferensbidrag (refereegranskat)abstract
- Incumbent manufacturing firms face challenges when expanding their product focus with digital services. Such expansion creates tensions in organizations in the servitization process. While management visions and conceptualizes new service oriented businesses, the actual practice of implementing these service concepts is influenced by the product paradigmatic way of thinking in the organization. This dominant thinking creates tensions between business visions and business practice. We use the case of remote diagnostics services to provide insights into a manufacturing firm’s attempt to transform the dominant oriented business models into a new networked environment. We suggest that such acts that may or may not lead to transition are lingered by dominant logics related to the product focus. This indicates that firms are required to embed new logics into their existing practice in order to exploit the full potential of digital technology. © 2014 IEEE.
|
|
| 5. |
- Akram, Asif, et al.
(författare)
-
Understanding Tensions in Incumbent Manufacturing Firms – A Study of Digitalized Products
- 2014
-
Ingår i: Proceedings of the 47th Annual Hawaii International Conference on System Sciences, Computer Society Press.
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Incumbent manufacturing firms face challenges when expanding their product focus with digital services. Such expansion creates tensions in organizations in the servitization process. While management visions and conceptualizes new service oriented businesses, the actual practice of implementing these service concepts is influenced by the product paradigmatic way of thinking in the organization. This dominant thinking creates tensions between business visions and business practice. We use the case of remote diagnostics services to provide insights into a manufacturing firm’s attempt to transform the dominant oriented business models into a new networked environment. We suggest that such acts that may or may not lead to transition are lingered by dominant logics related to the product focus. This indicates that firms are required to embed new logics into their existing practice in order to exploit the full potential of digital technology.
|
|
| 6. |
- Akram, Asif, et al.
(författare)
-
Value Network Transformation By Digital Service Innovation In The Vehicle Industry
- 2011
-
Ingår i: Proceedings of the 15th Pacific Asia Conference on Information Systems | Pacific Asia Conference on Information Systems (PACIS). - Brisbane, Australia : Association for Information Systems. - 9781864356441
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- This paper reports from preparations in an ongoing research study concerning how digital service innovation transforms value networks in the vehicle industry. The research study concerns digital services based on remote diagnostics systems. This digital service innovation in particular is of great importance since the vehicle industry has great potential to expand its business and found new and extended boundaries and relationships with other stakeholder in the networks they are attached to. Core challenges and opportunities for digital service innovation will lead us to the study of its influence on the business and innovation environment i.e. the value network. In this paper, we propose three propositions to study transformation from product oriented value networks to digital service oriented value networks.
|
|
| 7. |
|
|
| 8. |
- Carlsson, Christel, et al.
(författare)
-
Transport av kemiska bekämpningsmedel samt fastläggnings- och nedbrytningskarakterisering i en vertikal transekt genom mark- och grundvattenzonen i Vemmenhögs tillrinningsområde, södra Sverige
- 2013
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Projektets mål har varit att undersöka förekomst, fastläggning, transport och nedbrytning av kemiska bekämpningsmedel (KB) i djupare grundvatten i ett litet avrinningsområde i Vemmenhög i Skåne. Inom ramen för studien har grundvatten provtagits på varierande djup (5,5-35 m) och analyserats med avseende på 150 olika KB vid fem olika tillfällen utan att några detekterats (undantaget ett enstaka fynd av AMPA). Dessa djupare grundvatten daterades till mellan 40 och >60 år. I grunt grundvatten från området finns fynd av KB och med hjälp av statistisk analys av spridningsdata och data över fynd visades att den enskilt största faktorn som avgör om KB återfinns i grundvattnet eller ej är dosen vid besprutningstillfället. En högre dos ökar sannolikheten för fynd i grundvattnet. En matematisk modellering har genomförts för att förklara förekomst av 6 olika KB i grunt grundvatten. För modelleringen användes bl.a. experimentellt bestämda parametrar för nedbrytning och fastläggning. Modelleringen möjliggjorde att fynd av lågsorberande KB kunde kopplas till spridningen av dessa substanser, medan fynd av de relativt starkt sorberande substanserna inte kunde förklaras.
|
|
| 9. |
- Chowdhury, Soumitra, 1983-, et al.
(författare)
-
A Proposed Conceptual Framework For Identifying The Logic Of Digital Services
- 2011
-
Ingår i: Proceedings of the 15th Pacific Asia Conference on Information Systems, PACIS 2011. - Brisbane : Association for Information Systems. - 9781864356441
-
Konferensbidrag (refereegranskat)abstract
- In this paper, we propose a conceptual framework for identifying the logic of digital services. Digital services are those services that we acquire after the digitalization of previously non-digital products or services. The objective of the framework is to apply it in identifying the logic of digital services which are the results of digital innovation in the context of remote diagnostic services in the vehicle industry. While building the framework, looking at the transformation of the non-digital to digital service and the involvement of physical products, i.e., digital devices in the transformation, it was found essential to identify the logic of the digital services on the basis of service logic and goods logic.For that purpose, we have reviewed the literature on service logic and goods logic as those logics discuss differently about the determination and meaning of value, role of customer, role of physical products, primary unit of exchange and some other aspects which are important to know in case of transforming a non-digital service to digital service. These logics and the concept of digital innovation are utilized in building the framework for identifying the logic of digital services.
|
|
| 10. |
- Chowdhury, Soumitra, 1983-, et al.
(författare)
-
Architectural Characteristics of Digital Services Enabled by Embedded Technology : A Study on Remote Diagnostics Services
- 2014
-
Ingår i: Proceedings of the 47th Annual Hawaii International Conference on System Sciences. - Los Alamitos, CA : IEEE. - 9781479925056 - 9781479925049 ; , s. 3909-3918
-
Konferensbidrag (refereegranskat)abstract
- In this paper, we characterize the architecture of digital services that are enabled by embedded technology. Digitalization with embedded technology in physical products has become a common phenomenon. In spite of growing instance of such digitalization, little is known about the architectural characteristics of digital services enabled by embedded technology. Based on a research on vehicular remote diagnostics services, we characterize the architecture of such digital services. Following the framework on layered modular architecture continuum, our findings provide the following architectural characteristics: i) the architecture of the digital services spans along the layered modular architecture continuum, ii) the application program of the digital services is simultaneously de-coupled and partly coupled with the embedded devices, iii) there exist layers within layer of the digital services, iv) application program layer of the digital services is a closed innovation platform. © 2014 IEEE
|
|
