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The Helicobacter py...
The Helicobacter pylori Genome Project: insights into H. pylori population structure from analysis of a worldwide collection of complete genomes
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- Thorell, Kaisa, 1983 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
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Muñoz-Ramírez, Zilia Y. (author)
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Wang, Difei (author)
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Sandoval-Motta, Santiago (author)
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Boscolo Agostini, Rajiv (author)
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Ghirotto, Silvia (author)
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Torres, Roberto C. (author)
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Romero-Gallo, Judith (author)
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Krishna, Uma (author)
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Peek, Richard M. (author)
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Piazuelo, M. Blanca (author)
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Raaf, Naïma (author)
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Bentolila, Federico (author)
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Aftab, Hafeza (author)
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Akada, Junko (author)
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Matsumoto, Takashi (author)
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Haesebrouck, Freddy (author)
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Colanzi, Rony P. (author)
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Bartelli, Thais F. (author)
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Nunes, Diana Noronha (author)
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Pelosof, Adriane (author)
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Sztokfisz, Claudia Zitron (author)
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Dias-Neto, Emmanuel (author)
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Assumpção, Paulo Pimentel (author)
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Tishkov, Ivan (author)
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Mabeku, Laure Brigitte Kouitcheu (author)
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Goodman, Karen J. (author)
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Geary, Janis (author)
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Cromarty, Taylor J. (author)
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Price, Nancy L. (author)
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Quilty, Douglas (author)
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Corvalan, Alejandro H. (author)
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Serrano, Carolina A. (author)
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Gonzalez, Robinson (author)
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Riquelme, Arnoldo (author)
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García-Cancino, Apolinaria (author)
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Parra-Sepúlveda, Cristian (author)
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Bernal, Giuliano (author)
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Castillo, Francisco (author)
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Goldstein, Alisa M. (author)
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Hu, Nan (author)
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Taylor, Philip R. (author)
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Bravo, Maria Mercedes (author)
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Pazos, Alvaro (author)
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Bravo, Luis E. (author)
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Wilson, Keith T. (author)
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Fox, James G. (author)
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Ramírez-Mayorga, Vanessa (author)
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Molina-Castro, Silvia (author)
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Durán-Bermúdez, Sundry (author)
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Campos-Núñez, Christian (author)
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Chaves-Cervantes, Manuel (author)
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Tshibangu-Kabamba, Evariste (author)
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Tumba, Ghislain Disashi (author)
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Tshimpi-Wola, Antoine (author)
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de Jesus Ngoma-Kisoko, Patrick (author)
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Ngoyi, Dieudonné Mumba (author)
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Cruz, Modesto (author)
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Hosking, Celso (author)
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Abreu, José Jiménez (author)
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Varon, Christine (author)
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Benejat, Lucie (author)
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Secka, Ousman (author)
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Link, Alexander (author)
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Malfertheiner, Peter (author)
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Adinortey, Michael Buenor (author)
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Bockarie, Ansumana Sandy (author)
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Adinortey, Cynthia Ayefoumi (author)
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Ofori, Eric Gyamerah (author)
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Sgouras, Dionyssios N. (author)
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Martinez-Gonzalez, Beatriz (author)
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Michopoulos, Spyridon (author)
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Georgopoulos, Sotirios (author)
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Hernandez, Elisa (author)
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Tacatic, Braulio Volga (author)
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Aguilar, Mynor (author)
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Dominguez, Ricardo L. (author)
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Morgan, Douglas R. (author)
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Harðardóttir, Hjördís (author)
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Gunnarsdóttir, Anna Ingibjörg (author)
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Guðjónsson, Hallgrímur (author)
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Jónasson, Jón Gunnlaugur (author)
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Björnsson, Einar S. (author)
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Ballal, Mamatha (author)
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Shetty, Vignesh (author)
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Miftahussurur, Muhammad (author)
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Sugihartono, Titong (author)
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Alfaray, Ricky Indra (author)
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Waskito, Langgeng Agung (author)
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Fauzia, Kartika Afrida (author)
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Syam, Ari Fahrial (author)
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Maulahela, Hasan (author)
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Malekzadeh, Reza (author)
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Sotoudeh, Masoud (author)
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Peretz, Avi (author)
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Azrad, Maya (author)
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On, Avi (author)
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De Re, Valli (author)
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Zanussi, Stefania (author)
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Cannizzaro, Renato (author)
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(creator_code:org_t)
- 2023
- 2023
- English.
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In: Nature Communications. - 2041-1723. ; 14:1
- Related links:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Helicobacter pylori, a dominant member of the gastric microbiota, shares co-evolutionary history with humans. This has led to the development of genetically distinct H. pylori subpopulations associated with the geographic origin of the host and with differential gastric disease risk. Here, we provide insights into H. pylori population structure as a part of the Helicobacter pylori Genome Project (HpGP), a multi-disciplinary initiative aimed at elucidating H. pylori pathogenesis and identifying new therapeutic targets. We collected 1011 well-characterized clinical strains from 50 countries and generated high-quality genome sequences. We analysed core genome diversity and population structure of the HpGP dataset and 255 worldwide reference genomes to outline the ancestral contribution to Eurasian, African, and American populations. We found evidence of substantial contribution of population hpNorthAsia and subpopulation hspUral in Northern European H. pylori. The genomes of H. pylori isolated from northern and southern Indigenous Americans differed in that bacteria isolated in northern Indigenous communities were more similar to North Asian H. pylori while the southern had higher relatedness to hpEastAsia. Notably, we also found a highly clonal yet geographically dispersed North American subpopulation, which is negative for the cag pathogenicity island, and present in 7% of sequenced US genomes. We expect the HpGP dataset and the corresponding strains to become a major asset for H. pylori genomics.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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Thorell, Kaisa, ...
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Muñoz-Ramírez, Z ...
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Wang, Difei
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Sandoval-Motta, ...
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Boscolo Agostini ...
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Ghirotto, Silvia
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show more...
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Torres, Roberto ...
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Romero-Gallo, Ju ...
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Krishna, Uma
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Peek, Richard M.
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Piazuelo, M. Bla ...
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Raaf, Naïma
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Bentolila, Feder ...
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Aftab, Hafeza
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Akada, Junko
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Matsumoto, Takas ...
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Haesebrouck, Fre ...
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Colanzi, Rony P.
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Bartelli, Thais ...
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Nunes, Diana Nor ...
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Pelosof, Adriane
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Sztokfisz, Claud ...
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Dias-Neto, Emman ...
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Assumpção, Paulo ...
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Tishkov, Ivan
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Mabeku, Laure Br ...
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Goodman, Karen J ...
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Geary, Janis
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Cromarty, Taylor ...
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Price, Nancy L.
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Quilty, Douglas
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Corvalan, Alejan ...
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Serrano, Carolin ...
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Gonzalez, Robins ...
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Riquelme, Arnold ...
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García-Cancino, ...
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Parra-Sepúlveda, ...
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Bernal, Giuliano
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Castillo, Franci ...
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Goldstein, Alisa ...
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Hu, Nan
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Taylor, Philip R ...
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Bravo, Maria Mer ...
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Pazos, Alvaro
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Bravo, Luis E.
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Wilson, Keith T.
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Fox, James G.
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Ramírez-Mayorga, ...
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Molina-Castro, S ...
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Durán-Bermúdez, ...
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Campos-Núñez, Ch ...
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Chaves-Cervantes ...
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Tshibangu-Kabamb ...
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Tumba, Ghislain ...
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Tshimpi-Wola, An ...
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de Jesus Ngoma-K ...
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Ngoyi, Dieudonné ...
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Cruz, Modesto
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Hosking, Celso
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Abreu, José Jimé ...
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Varon, Christine
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Benejat, Lucie
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Secka, Ousman
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Link, Alexander
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Malfertheiner, P ...
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Adinortey, Micha ...
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Bockarie, Ansuma ...
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Adinortey, Cynth ...
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Ofori, Eric Gyam ...
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Sgouras, Dionyss ...
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Martinez-Gonzale ...
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Michopoulos, Spy ...
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Georgopoulos, So ...
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Hernandez, Elisa
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Tacatic, Braulio ...
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Aguilar, Mynor
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Dominguez, Ricar ...
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Morgan, Douglas ...
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Harðardóttir, Hj ...
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Gunnarsdóttir, A ...
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Guðjónsson, Hall ...
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Jónasson, Jón Gu ...
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Björnsson, Einar ...
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Ballal, Mamatha
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Shetty, Vignesh
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Miftahussurur, M ...
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Sugihartono, Tit ...
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Alfaray, Ricky I ...
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Waskito, Langgen ...
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Fauzia, Kartika ...
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Syam, Ari Fahria ...
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Maulahela, Hasan
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Malekzadeh, Reza
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Sotoudeh, Masoud
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Peretz, Avi
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Azrad, Maya
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On, Avi
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De Re, Valli
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Zanussi, Stefani ...
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Cannizzaro, Rena ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
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Nature Communica ...
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University of Gothenburg