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Safety of arterial ...
Safety of arterial shear wave elastography-ex-vivo assessment of induced strain and strain rates
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- Nordenfur, Tim, 1990- (författare)
- KTH,Medicinteknik och hälsosystem
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- Caidahl, Kenneth (författare)
- Karolinska Institutet
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- Grishenkov, Dmitry, Associate Professor, 1983- (författare)
- KTH,Medicinsk avbildning
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- Maksuti, Elira (författare)
- Karolinska Inst, Dept Physiol & Pharmacol, Anaesthesiol & Intens Care, Stockholm, Sweden.
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- Marlevi, David (författare)
- Karolinska Institutet
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- Urban, Matthew W. (författare)
- Mayo Clin, Dept Radiol, Rochester, MN USA.
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- Larsson, Matilda, 1981- (författare)
- KTH,Medicinsk avbildning,Dept Biomed Engn & Hlth Syst, Stockholm, Sweden
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(creator_code:org_t)
- 2022-07-19
- 2022
- Engelska.
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Ingår i: Biomedical Engineering & Physics Express. - : IOP Publishing. - 2057-1976. ; 8:5
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Shear wave elastography (SWE) is a promising technique for characterizing carotid plaques and assessing local arterial stiffness. The mechanical stress to which the tissue is subjected during SWE using acoustic radiation force (ARF), leading to strain at a certain strain rate, is still relatively unknown. Because SWEis increasingly used for arterial applications where the mechanical stress could potentially lead to significant consequences, it is important to understand the risks of SWE-induced strain and strain rate. The aim of this study was to investigate the safety of SWE in terms of induced arterial strain and strain rate ex-vivo and in a human carotid artery in-vivo. SWE was performed on six porcine aortae as a model of the human carotid artery using different combinations of ARF push parameters (push voltage: 60/90 V, aperture width: f/1.0/1.5, push length: 100/150/200 mu s) and distance to push position. The largest induced strain and strain rate were 1.46% and 54 s(-1) (90 V, f/ 1.0, 200 mu s), respectively. Moreover, the SWE-induced strains and strain rates increased with increasing push voltage, aperture, push length, and decreasing distance between the region of interest and the push. In the human carotid artery, the SWE-induced maximum strain was 0.06% and the maximum strain rate was 1.58 s(-1), compared with the maximum absolute strain and strain rate of 12.61% and 5.12 s(-1), respectively, induced by blood pressure variations in the cardiac cycle. Our results indicate that ex-vivo arterial SWE does not expose the artery to higher strain rate than normal blood pressure variations, and to strain one order of magnitude higher than normal blood pressure variations, at the push settings and distances from the region of interest used in this study.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- safety
- elastography
- shear wave elastography
- acoustic radiation force
- carotid
- arterial stiffness
- strain rate
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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