| 1. |
- Amaral, Rita, et al.
(författare)
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Profiling Persistent Asthma Phenotypes in Adolescents : A Longitudinal Diagnostic Evaluation from the INSPIRERS Studies
- 2021
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Ingår i: International Journal of Environmental Research and Public Health. - : MDPI. - 1661-7827 .- 1660-4601. ; 18:3
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Tidskriftsartikel (refereegranskat)abstract
- We aimed to identify persistent asthma phenotypes among adolescents and to evaluate longitudinally asthma-related outcomes across phenotypes. Adolescents (13-17 years) from the prospective, observational, and multicenter INSPIRERS studies, conducted in Portugal and Spain, were included (n = 162). Latent class analysis was applied to demographic, environmental, and clinical variables, collected at a baseline medical visit. Longitudinal differences in clinical variables were assessed at a 4-month follow-up telephone contact (n = 128). Three classes/phenotypes of persistent asthma were identified. Adolescents in class 1 (n = 87) were highly symptomatic at baseline and presented the highest number of unscheduled healthcare visits per month and exacerbations per month, both at baseline and follow-up. Class 2 (n = 32) was characterized by female predominance, more frequent obesity, and uncontrolled upper/lower airways symptoms at baseline. At follow-up, there was a significant increase in the proportion of controlled lower airway symptoms (p < 0.001). Class 3 (n = 43) included mostly males with controlled lower airways symptoms; at follow-up, while keeping symptom control, there was a significant increase in exacerbations/month (p = 0.015). We have identified distinct phenotypes of persistent asthma in adolescents with different patterns in longitudinal asthma-related outcomes, supporting the importance of profiling asthma phenotypes in predicting disease outcomes that might inform targeted interventions and reduce future risk.
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| 2. |
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| 3. |
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Espaços (Des)Habitados | (Un)Inhabited Spaces
- 2022
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Samlingsverk (redaktörskap) (refereegranskat)abstract
- This theme was defined in the winter of 2019, when no one predicted the pandemic crisis caused by COVID-19, which brought other dimensions and relevance to questions of inhabiting and uninhabiting spaces. At the time, there were other issues whose analysis seemed to be urgent: (1) gentrification and touristization of historical and environmentally protected sites; (2) occupation movements of uninhabited spaces; (3) territorial uprooting or intermittent rootedness, both resulting from mass human and cultural mobility, sometimes fostered by technological development and the globalization of the economy, sometimes determined by war, misery and hunger; (4) new (?) forms of ruralization or de-ruralization of regions with accentuated histories of population desertification. These processes are driven by the seduction of the economic and socio-cultural dynamism of cities, as well as by the search for alternative and more environmentally sustainable ways of re-inhabiting territories; (5)climate change, catastrophes, and processes of resettlement and regeneration; (6) and, among others, the inhabitation of space by art and art as an inhabited space. We therefore invited critical, theoretical-conceptual and artistic reflections on these topics, both in the current context of the Covid19 pandemic as in other contexts and approaches for the number5 of T RANSLOCAL-ContemporaryLocalandUrbanCultures.
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| 4. |
- Graça, Inês, et al.
(författare)
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Comparative Proteomic Analysis of Nodulated and Non-Nodulated Casuarina glauca Sieb. ex Spreng. Grown under Salinity Conditions Using Sequential Window Acquisition of All Theoretical Mass Spectra (SWATH-MS)
- 2020
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Ingår i: International Journal of Molecular Sciences. - : MDPI AG. - 1661-6596 .- 1422-0067. ; 21:1
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Tidskriftsartikel (refereegranskat)abstract
- Casuarina glauca displays high levels of salt tolerance, but very little is known about how this tree adapts to saline conditions. To understand the molecular basis of C. glauca response to salt stress, we have analyzed the proteome from branchlets of plants nodulated by nitrogen-fixing Frankia Thr bacteria (NOD+) and non-nodulated plants supplied with KNO3 (KNO3+), exposed to 0, 200, 400, and 600 mM NaCl. Proteins were identified by Short Gel, Long Gradient Liquid Chromatography coupled to Tandem Mass Spectrometry and quantified by Sequential Window Acquisition of All Theoretical Mass Spectra -Mass Spectrometry. 600 proteins were identified and 357 quantified. Differentially Expressed Proteins (DEPs) were multifunctional and mainly involved in Carbohydrate Metabolism, Cellular Processes, and Environmental Information Processing. The number of DEPs increased gradually with stress severity: (i) from 7 (200 mM NaCl) to 40 (600 mM NaCl) in KNO3+; and (ii) from 6 (200 mM NaCl) to 23 (600 mM NaCl) in NOD+. Protein-protein interaction analysis identified different interacting proteins involved in general metabolic pathways as well as in the biosynthesis of secondary metabolites with different response networks related to salt stress. Salt tolerance in C. glauca is related to a moderate impact on the photosynthetic machinery (one of the first and most important stress targets) as well as to an enhancement of the antioxidant status that maintains cellular homeostasis.
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| 5. |
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Guinchidos
- 2023
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Konstnärligt arbeteabstract
- Excerpt of my long poem Dia do Não with drawings by André Alves published in the anthology Futuros Multiespecie: Prácticas Vinculantes Para un Planeta en Emergencia. edited by Azucena Castro, Bartlebooth, July 2023 189-202.
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| 6. |
- Kanoni, Stavroula, et al.
(författare)
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Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis.
- 2022
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Ingår i: Genome biology. - : Springer Science and Business Media LLC. - 1474-760X .- 1465-6906 .- 1474-7596. ; 23:1
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Tidskriftsartikel (refereegranskat)abstract
- Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery.To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N=1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3-5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism.Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk.
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| 7. |
- Marques, Catarina, 1969-, et al.
(författare)
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Accuracy and Reliability of X-ray Measurements in the Cervical Spine
- 2020
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Ingår i: Asian Spine Journal. - : KOREAN SOC SPINE SURGERY. - 1976-1902 .- 1976-7846. ; 14:2, s. 169-176
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Tidskriftsartikel (refereegranskat)abstract
- Study Design: This study is a post hoc analysis of a multicenter prospective randomized controlled trial which compared artificial disc replacement and anterior cervical discectomy and fusion. Purpose: Useful radiographic parameters for assessing cervical alignment include the Cobb angles, T1 slope (TS), occipitocervical inclination (OCI). K-line tilt (KLT), and cervical sagittal vertical axis (cSVA). This study aimed to determine measurement accuracy and reliability for these parameters. Overview of Literature: Various authors have assessed repeatability by comparing different methods of measurement, but knowledge of measurement error and minimal detectable change is scarce. Methods: We evaluated 75B lateral cervical radiographs. One medical student and one spine surgeon (i.e., measured x2 within 4 weeks) independently measured the parameters obtaining 5,850 values. Standard error of measurement (SEm) and minimum detectable change (MDC) were calculated for each parameter. The accuracy and reliability of the Cobb angle measurements were calculated for the different types of angles: cervical lordosis, prosthesis angle, segmental angle with two hone surfaces (SABB), and segmental angle with one bone and one metal surface. Reliability was determined with intraclass correlation coefficient (ICC). Results: SEm was 1.8 degrees and MDC was 5.0 degrees for the Cobb angle, with an intraobserver/interobserver ICC of 0.958/0.8B6. All the different subtypes of Cobb angles had an ICC higher than 0.950, except SABB (intraobserver/interobserver ICC of 0.922/0.716). The most accurate and reliable measurement was for KLT. Conclusions: This study provides normative data on SEm and MDC for Cobb angles, T1S, KLT, OCI, and cSVA in cervicalcervicai lateral radiographs. Reliability was excellent for all parameters except SABB (e.g., good).
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| 8. |
- Marques, Catarina, 1969-, et al.
(författare)
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Unintended fusion in cervical artificial disk replacement : a prospective study on heterotopic ossification, progression, and clinical outcome, with 5-year follow-up
- 2021
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Ingår i: European spine journal. - : Springer. - 0940-6719 .- 1432-0932. ; 30:6, s. 1662-1669
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Tidskriftsartikel (refereegranskat)abstract
- Purpose Heterotopic ossification (HO) may cause unintended fusion in artificial disk replacement (ADR), failing to preserve motion. The reported incidence of HO varies hugely. This study aimed to determine prevalence of HO, progression, predisposing factors to occurrence and to progression, and potential effect on clinical outcomes. Methods Eighty-three patients treated with ADRs for cervical radiculopathy at one or two segments were extracted from a previously published RCT. Of the 83 patients, 59 had remaining ADR (79 implants) and sufficiently high-quality X-rays at 5 years of follow-up to allow analysis. HO was graded on plain films according to Mehren/Suchomel. Prevalence, progression, predisposing factors and effect on clinical outcome (Neck Disability Index-NDI) were analyzed. Results At 2 years, HO was seen in 46/55 ADR implants (84%), severe enough to affect mobility in 27/55 (49%). At 5 years, HO was seen in 92% of 79 implants, severe in 71%. Male sex was a predisposing factor to HO. No predisposing factors to progression were identified. NDI was not affected by the severity of HO. Conclusion Almost all ADR implants in our study have HO at 5 years of follow-up. Male sex is a risk factor. Severe HO did not affect clinical outcome.
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| 9. |
- Marques, Nuno, 1980-
(författare)
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A New Song for Ourselves : Contributions of Gary Snyder’s Poetics of Place to Current Ecopoetics
- 2020
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Ingår i: Ecocene: Cappadocia Journal of Environmental Humanities. - Cappadocia : Cappadocia University. - 2717-8943. ; 1:2, s. 32-46
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Tidskriftsartikel (refereegranskat)abstract
- I propose that Gary Snyder’s bioregional project can contribute to recent ecopoetic thought with its argument for poetry as embodied practice and with its definition of community as place-based, transnational, and multi-species. I start by showing continuities between bioregionalism and ecocriticism with the concept of place. I then turn to Snyder’s conceptualization of place as a dialectics between the biotic and sociopolitical dimensions. For Snyder poetry is a situated and embodied practice of investigation and creation of place. It therefore relates with recent discussions on ecopoetics as a critical and poetic practice extended to ecologically oriented forms of community action and activism (Hume and Osborne 2018,2). As an example of how current ecopoetry practices a poetics of place I briefly discuss Allison Cobb’s Plastic: An Autobiography(2015).
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| 10. |
- Marques, Nuno, 1980-
(författare)
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Atmospheric and geological entanglements : north american ecopoetry and the anthropocene
- 2020
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Atmospheric and Geological Entanglements is a study of contemporary North American ecopoetry, a poetry which is characterized by a negotiation or subversion of established cultural representations of nature, and by a re-deployment of poetic forms such as lyrical poetry, pastoral and elegy. The studied poets experiment with form and question well-established categories such as human and nature, instead emphasizing connections between the human, other organisms, and inorganic matter. Their poetry—one of several results of their artistic and critical practice, or poetics—thus highlights entanglements of various kinds and draws attention to the world as varied, complex and interconnected. The study has a specific focus on how twentieth-century ecopoetry relates to two material and aesthetic dimensions of the Anthropocene: the atmospheric and the geological. Geological imagery has been dominant in discussions about and in the Anthropocene, but ecopoetry emphasizes song, breathing and air as liberating atmospheric figures for communication and relationships, and for thinking with others and the planet.
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