WFRF:(Martens John W.M.)
Search: WFRF:(Martens John W.M.) > (2015) > Frequent somatic tr...
- 1 of 1
- Previous record
- Next record
- To hitlist
Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells.
- Ju, Young Seok (author)
- Tubio, Jose M C (author)
- Mifsud, William (author)
- show more...
- Fu, Beiyuan (author)
- Davies, Helen R (author)
- Ramakrishna, Manasa (author)
- Li, Yilong (author)
- Yates, Lucy (author)
- Gundem, Gunes (author)
- Tarpey, Patrick S (author)
- Behjati, Sam (author)
- Papaemmanuil, Elli (author)
- Martin, Sancha (author)
- Fullam, Anthony (author)
- Gerstung, Moritz (author)
- Nangalia, Jyoti (author)
- Green, Anthony R (author)
- Caldas, Carlos (author)
- Tutt, Andrew (author)
- Lee, Ming Ta Michael (author)
- Van't Veer, Laura J (author)
- Tan, Benita K T (author)
- Aparicio, Samuel (author)
- Span, Paul N (author)
- Martens, John W M (author)
- Knappskog, Stian (author)
- Vincent-Salomon, Anne (author)
- Børresen-Dale, Anne-Lise (author)
- Eyfjörd, Jórunn Erla (author)
- Flanagan, Adrienne M (author)
- Foster, Christopher (author)
- Neal, David E (author)
- Cooper, Colin (author)
- Eeles, Rosalind (author)
- Lakhani, Sunil R (author)
- Desmedt, Christine (author)
- Thomas, Gilles (author)
- Richardson, Andrea L (author)
- Purdie, Colin A (author)
- Thompson, Alastair M (author)
- McDermott, Ultan (author)
- Yang, Fengtang (author)
- Nik-Zainal, Serena (author)
- Campbell, Peter J (author)
- Stratton, Michael R (author)
- show less...
- (creator_code:org_t)
- show more...
- show less...
- 2015-05-11
- 2015
- English.
- In: Genome Research. - : Cold Spring Harbor Laboratory. - 1549-5469 .- 1088-9051. ; 25:6, s. 814-824
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Mitochondrial genomes are separated from the nuclear genome for most of the cell cycle by the nuclear double membrane, intervening cytoplasm, and the mitochondrial double membrane. Despite these physical barriers, we show that somatically acquired mitochondrial-nuclear genome fusion sequences are present in cancer cells. Most occur in conjunction with intranuclear genomic rearrangements, and the features of the fusion fragments indicate that nonhomologous end joining and/or replication-dependent DNA double-strand break repair are the dominant mechanisms involved. Remarkably, mitochondrial-nuclear genome fusions occur at a similar rate per base pair of DNA as interchromosomal nuclear rearrangements, indicating the presence of a high frequency of contact between mitochondrial and nuclear DNA in some somatic cells. Transmission of mitochondrial DNA to the nuclear genome occurs in neoplastically transformed cells, but we do not exclude the possibility that some mitochondrial-nuclear DNA fusions observed in cancer occurred years earlier in normal somatic cells.
Subject headings
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
- Genome Research (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Ju, Young Seok
- Tubio, Jose M C
- Mifsud, William
- Fu, Beiyuan
- Davies, Helen R
- Ramakrishna, Man ...
- show more...
- Li, Yilong
- Yates, Lucy
- Gundem, Gunes
- Tarpey, Patrick ...
- Behjati, Sam
- Papaemmanuil, El ...
- Martin, Sancha
- Fullam, Anthony
- Gerstung, Moritz
- Nangalia, Jyoti
- Green, Anthony R
- Caldas, Carlos
- Borg, Åke
- Tutt, Andrew
- Lee, Ming Ta Mic ...
- Van't Veer, Laur ...
- Tan, Benita K T
- Aparicio, Samuel
- Span, Paul N
- Martens, John W ...
- Knappskog, Stian
- Vincent-Salomon, ...
- Børresen-Dale, A ...
- Eyfjörd, Jórunn ...
- Flanagan, Adrien ...
- Foster, Christop ...
- Neal, David E
- Cooper, Colin
- Eeles, Rosalind
- Lakhani, Sunil R
- Desmedt, Christi ...
- Thomas, Gilles
- Richardson, Andr ...
- Purdie, Colin A
- Thompson, Alasta ...
- McDermott, Ultan
- Yang, Fengtang
- Nik-Zainal, Sere ...
- Campbell, Peter ...
- Stratton, Michae ...
- Ehinger, Anna
- show less...
- About the subject
-
- NATURAL SCIENCES
- NATURAL SCIENCES
- and Biological Scien ...
- and Genetics
- Articles in the publication
- Genome Research
- By the university
- Lund University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
