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- Martin, Lene, 1953-
(författare)
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Clinical experience with Latanoprost : a retrospective study of 153 patients
- 1999
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Ingår i: Acta Ophthalmologica Scandinavica. - : Wiley. - 1395-3907 .- 1600-0420. ; 77:3, s. 336-339
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: To evaluate the pressure-reducing effect of latanoprost in a clinical setting. Patients and methods: Data from 153 consecutive patients with open angle glaucoma receiving latanoprost were recorded at baseline (=153), 2 weeks (n=151) and 8 to 12 months (n=89) after starting latanoprost treatment, In 82 patients (54%) latanoprost was added to ongoing treatment, Two patients terminated treatment because of side effects before the first follow-up examination, Results: 56% (84/151) of the patients showed an intraocular pressure reduction of 20% or more after 2 weeks, regardless of baseline therapy. The difference between intraocular pressure before (24.4+/-5.8 mm Hg) and after 2 weeks of latanoprost treatment (19.9+/-6.9 mm Hg) in the total group (n=151) was highly significant (p<0.0001). The pressure reduction was significantly correlated,vith the pretreatment intraocular pressure level (r=0.48, p<0.0001). In the 89 patients who could be followed for 8 to 12 months no significant upward drift in mean intraocular pressure was observed, but in fourteen patients intraocular pressure increased with 5 mm Hg or more. Thirteen patients reported side effects, five of these discontinued the treatment. Conclusion: Latanoprost is obviously an efficient pressure reducing drug which can be used in glaucoma patients as an adjunct to any ongoing therapy with the expectation of clinically relevant intraocular pressure reduction in 45-71% of the patients.
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| 3. |
- Martin, Lene, 1953-
(författare)
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Computerized method to measure glare and contrast sensitivity in cataract patients
- 1999
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Ingår i: Journal of cataract and refractive surgery. - 0886-3350 .- 1873-4502. ; 25:3, s. 411-415
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: To evaluate computerized methods for measuring glare sensitivity and visual acuity at 3 contrast levels in cataract patients. Setting: St. Erik's Eye Hospital, Stockholm, Sweden. Methods: In a prospective study, 25 consecutive cataract patients meeting the inclusion criteria were examined before and 12 weeks after cataract surgery. Measured were glare sensitivity and visual acuity at 3 contrast levels using the Ophthimus Y-VA Contrast Sensitivity lest and Glare Test. Results: Preoperatively, ail patients had impaired values compared with those in a group of age-matched normal volunteers (control group). Postoperatively, median values were similar to those in the age-matched control group in all parameters except glare sensitivity, which was significantly higher in the pseudophakic group (P = .03). Correlation coefficients between preoperative visual acuity and contrast sensitivity at 90%, 25%, and 10% were 0.50 (P = .01), 0.53 (P = .006), and 0.45 (P = .02), respectively, and between preoperative visual acuity and preoperative glare difference, 0.45 (P = .02). A significant correlation was found between age and visual acuity in the control group at all contrast levels: 90% (r = 0.61, P = .0018 ), 25% (r = 0.52, P = .01), and 10% (r = 0.42, P = .04). Median differences between Y-VA examinations (repeatability) were 0 LogMAR except between examinations 1 and 2 at the 25% contrast level, where it was 0.3 LogMAR. Conclusion: The Ophthimus Y-VA Test and Glare Test were useful in the preoperative evaluation of patients with cataract and mild to moderate visual impairment.
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| 7. |
- Wanger, Peter, 1940-, et al.
(författare)
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Management of ocular hypertension and open-angle glaucoma : clinical practice and computer-assisted decision-making
- 1997
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Ingår i: Acta Ophthalmologica Scandinavica. - : Wiley. - 1395-3907 .- 1600-0420. ; 75:6, s. 700-704
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: To evaluate the feasibility of computerized decision support in the management of patients with open angle glaucoma or ocularhypertension. Method: Based on a Swedish consensus document a computer program was developed, which provided one of 25 different recommendations for appropriate action. In 373 patient visits to seven different eye clinics, the program's recommendations were compared to the actual decisions made by the responsible ophthalmologists. Results: Notable differences were observed between the clinics' managementstrategies, especially regarding follow-up frequency and start or increase of antiglaucoma treatment. The program's recommendations conformed with the clinical decisions in 23 to 92% of the cases when a standard management strategy was simulated. The concordance increased to 93 to 100%, when policy differences between the clinics were taken into account. Conclusion: Clinical decision-making in the management of patients with ocular hypertension or open angle glaucoma can be implemented in a computer program. The optimum management protocol remains to be defined.
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