| 1. |
- Lilja, Linus, et al.
(författare)
-
Target temperature 34 vs. 36°C after out-of-hospital cardiac arrest - a retrospective observational study.
- 2017
-
Ingår i: Acta anaesthesiologica Scandinavica. - : Wiley. - 1399-6576 .- 0001-5172. ; 61:9, s. 1176-1183
-
Tidskriftsartikel (refereegranskat)abstract
- Intensive care for comatose survivors of cardiac arrest includes targeted temperature management (TTM) to attenuate cerebral reperfusion injury. A recent multi-center clinical trial did not show any difference in mortality or neurological outcome between TTM targeting 33°C or 36°C after out-of-hospital-cardiac-arrest (OHCA). In our institution, the TTM target was changed accordingly from 34 to 36°C. The aim of this retrospective study was to analyze if this change had affected patient outcome.Intensive care registry and medical record data from 79 adult patients treated for OHCA with TTM during 2010 (n=38; 34°C) and 2014 (n=41; 36°C) were analyzed for mortality and neurological outcome were assessed as cerebral performance category. Student's t-test was used for continuous data and Fischer's exact test for categorical data, and multivariable logistic regression was applied to detect influence from patient factors differing between the groups.Witnessed arrest was more common in 2010 (95%) vs. 2014 (76%) (P=0.03) and coronary angiography was more common in 2014 (95%) vs. 2010 (76%) (P=0.02). The number of patients awakening later than 72h after the arrest did not differ. After adjusting for gender, hypertension, and witnessed arrest, neither 1-year mortality (P=0.77), nor 1-year good neurological outcome (P=0.85) differed between the groups.Our results, showing no difference between TTM at 34°C and TTM at 36°C as to mortality or neurological outcome after OHCA, are in line with the previous TTM-trial results, supporting the use of either target temperature in our institution.
|
|
| 2. |
- Martinell, Louise
(författare)
-
Aspects of post-resuscitation care after out-of-hospital cardiac arrest
- 2017
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Background: Cardiac disease is the most common cause of death in the western world and the majority of these deaths are due to out-of-hospital cardiac arrest (OHCA). In Sweden, approximately 10,000 persons suffer an OHCA annually and in 5000 cardiopulmonary resuscitation (CPR) is initiated. The successful return of spontaneous circulation (ROSC) and admission to hospital are just the first steps towards the goal of complete recovery from cardiac arrest. Aims: The aims of Papers I, II and IV were to evaluate different aspects of post-resuscitation care and their importance for survival after OHCA. These aspects included the use of implantable cardioverter defibrillators (ICD) and mild induced hypothermia (MIH). The aim of Paper III was to use variables and information available at intensive care unit admission to develop a risk score for poor outcome useful for comparing populations and defining patient risk when assessing effects and creating power calculations in interventional studies. Methods: Papers I, II and IV were retrospective observational studies of OHCA patients admitted to hospital in Gothenburg during different periods of time from 1980-2015 (n=1,609, n=390 and n=871). Paper III is a post-hoc analysis of the randomized multicenter Target Temperature Management trial (n=933). Results: In Paper I, we did not find any significant change in one-year survival between the two time periods (1980-2002 and 2003-2006) when all the patients were studied (27% vs. 32%; P = 0.14). Among patients found in ventricular fibrillation, an increase in one-year survival was found (37% vs. 57%; P=0.0001). The proportion of survivors to hospital discharge with low cerebral function (cerebral performance category score 3) decreased from 28% to 6% (P = 0.0006) among all patients. The use of ICDs increased (Paper II), but, in overall terms, only 58 of 390 survivors (15%) received an ICD. Among patients who received an ICD, the two-year mortality was 2%, versus 25% among those who did not (p < 0.0001). The long-term follow-up showed that the use of an ICD had a borderline association with lower risk of death (adjusted hazard ratio 0.49; 95% confidence interval (CI), 024-1.01; p = 0.052). In Paper III, we identified ten independent predictors of a poor outcome among patients who had ROSC on admission to hospital and created a risk score based on the impact of each of these variables. This score yielded a median area under the curve of 0.842 (range; 0.840-0.845) and good calibration. In Paper IV, we used a stratified propensity score analysis to adjust for factors potentially influencing choice of treatment with MIH. The odds ratio (OR) for 30-day survival was not significantly higher in patients treated with MIH compared with non-MIH-treated patients; OR 1.33 (95% CI 0.83-2.15; p=0.24). A good neurological outcome at hospital discharge was seen in 82% of patients who were discharged alive from hospital. Conclusions: We did not find any overall improvement in survival over time among patients who had ROSC on admission to hospital after OHCA, but we found signs of improved cerebral function among survivors to hospital discharge, following the introduction of more intensified post-resuscitation care. The use of ICDs was low but increased over time. Among survivors of OHCA caused by ventricular fibrillation or tachycardia who received an ICD during hospitalization, only 2% died during the following two years. Patients running a high risk of a poor outcome after OHCA could be identified at an early stage by using a simple, easy-to-use risk score, based on ten independent predictors of a poor outcome at six months. Treatment with mild induced hypothermia was not significantly associated with an increased chance of 30-day survival among patients who were still unconscious on admission to hospital after OHCA.
|
|
| 3. |
- Martinell, Louise, et al.
(författare)
-
Early predictors of poor outcome after out-of-hospital cardiac arrest.
- 2017
-
Ingår i: Critical Care. - : Springer Science and Business Media LLC. - 1364-8535 .- 1466-609X. ; 21:1
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Early identification of predictors for a poor long-term outcome in patients who survive the initial phase of out-of-hospital cardiac arrest (OHCA) may facilitate future clinical research, the process of care and information provided to relatives. The aim of this study was to determine the association between variables available from the patient's history and status at intensive care admission with outcome in unconscious survivors of OHCA.METHODS: Using the cohort of the Target Temperature Management trial, we performed a post hoc analysis of 933 unconscious patients with OHCA of presumed cardiac cause who had a complete 6-month follow-up. Outcomes were survival and neurological function as defined by the Cerebral Performance Category (CPC) scale at 6 months after OHCA. After multiple imputations to compensate for missing data, backward stepwise multivariable logistic regression was applied to identify factors independently predictive of a poor outcome (CPC 3-5). On the basis of these factors, a risk score for poor outcome was constructed.RESULTS: We identified ten independent predictors of a poor outcome: older age, cardiac arrest occurring at home, initial rhythm other than ventricular fibrillation/tachycardia, longer duration of no flow, longer duration of low flow, administration of adrenaline, bilateral absence of corneal and pupillary reflexes, Glasgow Coma Scale motor response 1, lower pH and a partial pressure of carbon dioxide in arterial blood value lower than 4.5 kPa at hospital admission. A risk score based on the impact of each of these variables in the model yielded a median (range) AUC of 0.842 (0.840-0.845) and good calibration. Internal validation of the score using bootstrapping yielded a median (range) AUC corrected for optimism of 0.818 (0.816-0.821).CONCLUSIONS: Among variables available at admission to intensive care, we identified ten independent predictors of a poor outcome at 6 months for initial survivors of OHCA. They reflected pre-hospital circumstances (six variables) and patient status on hospital admission (four variables). By using a simple and easy-to-use risk scoring system based on these variables, patients at high risk for a poor outcome after OHCA may be identified early.
|
|
| 4. |
- Martinell, Louise, et al.
(författare)
-
Mild induced hypothermia and survival after out-of-hospital cardiac arrest.
- 2017
-
Ingår i: American Journal of Emergency Medicine. - : Elsevier BV. - 0735-6757 .- 1532-8171. ; 35:11, s. 1595-1600
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Mild induced hypothermia (MIH) was introduced for post cardiac arrest care in Sweden in 2003, based on two clinical trials. This retrospective study evaluated its association with 30-day survival after out-of-hospital cardiac arrest (OHCA) in a Swedish community from 2003 to 2015.METHODS: Out of 3680 patients with OHCA, 1100 were hospitalized after return of spontaneous circulation and 871 patients who remained unconscious were included in the analysis. Prehospital data were extracted from the Swedish Registry of Cardiopulmonary Resuscitation and in-hospital data were extracted from clinical records. Propensity score analysis on complete data sets and multivariable logistic regression with multiple imputations to compensate for missing data were performed.RESULTS: Unadjusted 30-day survival was 23.5%; 37% in 386/871 (44%) MIH treated and 13% in 485/871 (56%) non-MIH treated patients. Unadjusted odds ratio (OR) for 30-day survival in patients treated with MIH compared to non-MIH treated patients was 3.79 (95% CI 2.71-5.29; p<0.0001). Using stratified propensity score analysis and in addition adjusting for in-hospital factors, 30-day survival was not significantly different in patients treated with MIH compared to non-MIH treated patients; OR 1.33 (95% CI 0.83-2.15; p=0.24). Using multiple imputations to handle missing data yielded a similar adjusted OR of 1.40 (95% CI 0.88-2.22; p=0.15). Good neurologic outcome at hospital discharge was seen in 82% of patients discharged alive.CONCLUSION: Treatment with MIH was not significantly associated with increased 30-day survival in patients remaining unconscious after OHCA when adjusting for potential confounders.
|
|
| 5. |
- Martinell, Louise, et al.
(författare)
-
Mild induced hypothermia and survival after out-of-hospital cardiac arrest in a Swedish urban area
- 2017
-
Ingår i: American Journal of Emergency Medicine. - : Elsevier BV. - 0735-6757 .- 1532-8171. ; 35:11, s. 1595-1600
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Mild induced hypothermia (MIH) was introduced for post cardiac arrest care in Sweden in 2003, based on two clinical trials. This retrospective study evaluated its association with 30-day survival after out-of-hospital cardiac arrest (OHCA) in a Swedish community from 2003 to 2015. Methods: Out of 3680 patients with OHCA, 1100 were hospitalized after return of spontaneous circulation and 871 patients who remained unconscious were included in the analysis. Prehospital data were extracted from the Swedish Registry of Cardiopulmonary Resuscitation and in-hospital data were extracted from clinical records. Propensity score analysis on complete data sets and multivariable logistic regression with multiple imputations to compensate for missing data were performed. Results: Unadjusted 30-day survival was 23.5%; 37% in 386/871 (44%) MIH treated and 13% in 485/871 (56%) non-MIH treated patients. Unadjusted odds ratio (OR) for 30-day survival in patients treated with MIH compared to non-MIH treated patients was 3.79 (95% CI 2.71-5.29; p. <. 0.0001). Using stratified propensity score analysis and in addition adjusting for in-hospital factors, 30-day survival was not significantly different in patients treated with MIH compared to non-MIH treated patients; OR 1.33 (95% CI 0.83-2.15; p = 0.24). Using multiple imputations to handle missing data yielded a similar adjusted OR of 1.40 (95% CI 0.88-2.22; p = 0.15). Good neurologic outcome at hospital discharge was seen in 82% of patients discharged alive. Conclusion: Treatment with MIH was not significantly associated with increased 30-day survival in patients remaining unconscious after OHCA when adjusting for potential confounders.
|
|
